Catalog No.
RHJ67501
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Monoclonal
Tested applications
IF: 1:50-1:200, IHC: 1:50-1:100, WB: 1:500-1:1000
Target
TREX1, Deoxyribonuclease III, DNase III, Three-prime repair exonuclease 1, 3'-5' exonuclease TREX1
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q9NSU2
Applications
IF, IHC, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 0.05% BSA, 50% Glycerol, 0.05% Sodium azide.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 4 ℃ for frequent use. Store at -20 ℃ for twelve months from the date of receipt.
Clone ID
R2K48
Expanding the spectrum of genetic causes of DNA-specific exonuclease TREX1 variants in thrombotic microangiopathy., PMID:40383229
Tissue factor promotes TREX1 protein stability to evade cGAS-STING innate immune response in pancreatic ductal adenocarcinoma., PMID:39658648
The SLE-associated TREX1-P212fs mutation disrupts ER association leading to type I interferonopathy., PMID:39621297
cGAS activation in classical dendritic cells causes autoimmunity in TREX1-deficient mice., PMID:39254994
Crizanlizumab for retinal vasculopathy with cerebral leukoencephalopathy in a phase II clinical study., PMID:38950286
The Expression Levels of TREX1 and IFN-α Are Associated with Immune Reconstitution in HIV-1-Infected Individuals., PMID:38675842
TREX1 531C/T Polymorphism and Autoantibodies Associated with the Immune Status of HIV-1-Infected Individuals., PMID:37298611
Analysis of clinical characteristics of children with Aicardi-Goutieres syndrome in China., PMID:35551623
cGAS-STING Pathway Does Not Promote Autoimmunity in Murine Models of SLE., PMID:33854495
Development of novel highly sensitive methods to detect endogenous cGAMP in cells and tissue., PMID:31982420
TREX1 531C>T Polymorphism is Associated with High Proviral Load Levels in HTLV-1-Infected Persons., PMID:31861565
Genetic contributors and soluble mediators in prediction of autoimmune comorbidity., PMID:31444033
A bioactive mammalian disaccharide associated with autoimmunity activates STING-TBK1-dependent immune response., PMID:31147550
[Familial chilblain lupus: Four cases spanning three generations]., PMID:30217686
TREX1 is expressed by microglia in normal human brain and increases in regions affected by ischemia., PMID:30062819
DNase-active TREX1 frame-shift mutants induce serologic autoimmunity in mice., PMID:28325644
Retinal vasculitis., PMID:26945335
Activation of cyclic GMP-AMP synthase by self-DNA causes autoimmune diseases., PMID:26371324
Cutting Edge: cGAS Is Required for Lethal Autoimmune Disease in the Trex1-Deficient Mouse Model of Aicardi-Goutières Syndrome., PMID:26223655
Exonuclease TREX1 degrades double-stranded DNA to prevent spontaneous lupus-like inflammatory disease., PMID:25848017
Familial chilblain lupus due to a novel mutation in the exonuclease III domain of 3' repair exonuclease 1 (TREX1)., PMID:25517357
Rare variants in the TREX1 gene and susceptibility to autoimmune diseases., PMID:24224166
Assessment of interferon-related biomarkers in Aicardi-Goutières syndrome associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, and ADAR: a case-control study., PMID:24183309
Dysregulation of the immune system in Aicardi-Goutières syndrome: another example in a TREX1-mutated patient., PMID:23918923
Innate immune sensing of HIV-1 by dendritic cells., PMID:23084911
Type I IFN system in the development and manifestations of SLE., PMID:22832823
SAMHD1 is a nucleic-acid binding protein that is mislocalized due to aicardi-goutières syndrome-associated mutations., PMID:22461318
Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population., PMID:22087647
Defects in DNA degradation revealed in crystal structures of TREX1 exonuclease mutations linked to autoimmune disease., PMID:22071149
Endogenous retroviral pathogenesis in lupus., PMID:20644481
Expanding the phenotypic spectrum of lupus erythematosus in Aicardi-Goutières syndrome., PMID:20131292
Pathogenic mechanisms in systemic lupus erythematosus., PMID:20014960
Early onset of autoimmune disease by the retroviral integrase inhibitor raltegravir., PMID:19923437
Familial chilblain lupus--a monogenic form of cutaneous lupus erythematosus due to a heterozygous mutation in TREX1., PMID:19478477
The SET complex acts as a barrier to autointegration of HIV-1., PMID:19266025
The TREX1 double-stranded DNA degradation activity is defective in dominant mutations associated with autoimmune disease., PMID:18805785
Trex1 prevents cell-intrinsic initiation of autoimmunity., PMID:18724932
TREX1 polymorphisms associated with autoantibodies in patients with systemic lupus erythematosus., PMID:18092167
Cyclin-dependent kinase 2 dependent phosphorylation of ATRIP regulates the G2-M checkpoint response to DNA damage., PMID:17638878
A mutation in TREX1 that impairs susceptibility to granzyme A-mediated cell death underlies familial chilblain lupus., PMID:17440703
Amino-terminal domain of ATRIP contributes to intranuclear relocation of the ATR-ATRIP complex following DNA damage., PMID:15527801
ATR-dependent phosphorylation of ATRIP in response to genotoxic stress., PMID:15451423
For research use only. Not for human or drug use.
