Catalog No.
SGK61516
Species
General
Endotoxin level
Please contact with the lab for this information.
Accession
976-71-6
Applications
ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
phanurane;pregna-4,6-diene-21-carboxylicacid,17-hydroxy-3-oxo-,gamma-lactone,(17-alph;sc9376;spirolactonesc14266;CANRENOICACIDGAMMALACTONE;CANRENONE;CANRENONE-D4;4,6-ANDROSTADIEN[(17(B-1')-SPIRO-5')]-PERHYDROFURAN-2,3-DIONE
Model-Informed Dose Optimization of Spironolactone in Neonates and Infants., PMID:40143132
Mineralocorticoid Receptor Antagonism Reduces Atrial Arrhythmias Post-Cardiac Surgery and Attenuates Atrial Stress Responses to Cardioplegic Arrest., PMID:40060465
Dose-exposure-response of CARDALIS® (benazepril/spironolactone) on the classical and alternative arms of the renin-angiotensin-aldosterone system in healthy dogs., PMID:39601373
Association between mineralocorticoid receptor antagonists and kidney harm: A systematic review and meta-analysis of randomized controlled trials., PMID:39578707
Untargeted metabolomics to detect and identify plasma metabolic signatures associated with intracranial aneurysm and its rupture., PMID:39549086
Marine Bacillus pumilus substances exhibit antimicrobial effect on multidrug-resistant Staphylococcus aureus., PMID:39401988
Endogenous bufadienolides, mineralocorticoid receptor antagonists and fibrosis in chronic kidney disease., PMID:39295945
Allergic Contact Dermatitis to Topical Preparations Containing Minoxidil: A Systematic Review and Individual Participant Data Meta-Analysis., PMID:38885151
Mineralocorticoid receptor antagonists in heart failure with reduced ejection fraction: a systematic review and network meta-analysis of 32 randomized trials., PMID:38692445
Spironolactone metabolite causes falsely increased progesterone in the Abbott Architect immunoassay., PMID:38484829
Comprehensive characterization of the effect of mineralocorticoid receptor antagonism with spironolactone on the renin-angiotensin-aldosterone system in healthy dogs., PMID:38394253
Probing the hair detectability of prohibited substances in sports: an in vivo-in silico-clinical approach and analytical implications compared with plasma, urine, and faeces., PMID:38224356
Water and Electrolyte Content in Salt-Dependent HYpertension in the SKIn (WHYSKI): Effect of Surgical Cure of Primary Aldosteronism., PMID:38123759
Eco-friendly solvent bar microextraction based on a natural deep eutectic solvent and multivariate optimization for simultaneous determination of spironolactone and canrenone in urine and plasma samples., PMID:38079037
Pharmacokinetics of oral spironolactone in infants up to 2 years of age., PMID:38041740
Endogenous Digitalis-like Factors as a Key Molecule in the Pathophysiology of Pregnancy-Induced Hypertension and a Potential Therapeutic Target in Preeclampsia., PMID:37628922
Estradiol and Spironolactone Plasma Pharmacokinetics Among Brazilian Transgender Women Using HIV Pre-Exposure Prophylaxis: Analysis of Potential Interactions., PMID:37261664
An Indonesian slimming drug with undeclared ingredients causing harm., PMID:36808870
Exploration of sodium homeostasis and pharmacokinetics in bile duct-ligated rats treated by anti-cirrhosis herbal formula plus spironolactone., PMID:36744253
Novel approach to adherence assessment based on parent drug and metabolite pharmacokinetics: pilot study with spironolactone., PMID:36472169
Spontaneous Remission of Primary Aldosteronism with Mineralocorticoid Receptor Antagonist Therapy: A Review., PMID:36430298
Closing the gap - development of an analytical methodology using volumetric absorptive microsampling of finger prick blood followed by LC-HRMS/MS for adherence monitoring of antihypertensive drugs., PMID:36318313
Activation of RAAS Signaling Contributes to Hypertension in Aged Hyp Mice., PMID:35884995
Development of UHPLC-MS/MS methods to quantify 25 antihypertensive drugs in serum in a cohort of patients treated for hypertension., PMID:35803015
Engineering of a fungal steroid 11α-hydroxylase and construction of recombinant yeast for improved production of 11α-hydroxyprogesterone., PMID:35654275
Association between Mineralocorticoid Receptor Antagonist and Mortality in SARS-CoV-2 Patients: A Systematic Review and Meta-Analysis., PMID:35455823
Adherence and blood pressure control in patients with primary aldosteronism., PMID:35438025
Canrenone Restores Vasorelaxation Impaired by Marinobufagenin in Human Preeclampsia., PMID:35328757
Sex Differences in Spironolactone and the Active Metabolite Canrenone Concentrations and Adherence., PMID:35052816
Topical Treatment of Human Skin and Cultured Keratinocytes with High-Dose Spironolactone Reduces XPB Expression and Induces Toxicity., PMID:34909723
Model-Informed Optimization of a Pediatric Clinical Pharmacokinetic Trial of a New Spironolactone Liquid Formulation., PMID:34201093
Polymeric micelle mediated follicular delivery of spironolactone: Targeting the mineralocorticoid receptor to prevent glucocorticoid-induced activation and delayed cutaneous wound healing., PMID:34090990
The Role of the Mineralocorticoid Receptor and Mineralocorticoid Receptor-Directed Therapies in Heart Failure., PMID:34050730
Novel polar AhR-active chemicals detected in sediments of an industrial area using effect-directed analysis based on in vitro bioassays with full-scan high resolution mass spectrometric screening., PMID:34030261
Effects of Impeller Geometry on the 11α-Hydroxylation of Canrenone in Rushton Turbine-Stirred Tanks., PMID:34024892
Aldosterone Is Positively Associated With Circulating FGF23 Levels in Chronic Kidney Disease Across Four Species, and May Drive FGF23 Secretion Directly., PMID:33995120
Mineralocorticoid Receptor Antagonist Effect on Aldosterone to Renin Ratio in Patients With Primary Aldosteronism., PMID:33942084
Assessing Adherence to Antihypertensive Medication by Means of Dose-Dependent Reference Plasma Concentration Ranges and Ultra-High Performance Liquid Chromatography-Ion Trap Mass Spectrometry Analysis., PMID:33803489
Underestimated reactions and regulation patterns of adrenal cytochromes P450., PMID:33722664
Primary aldosteronism: considerations about the evaluation of the aldosterone to renin ratio during canrenone treatment., PMID:33454931
Aldosterone antagonists in addition to renin angiotensin system antagonists for preventing the progression of chronic kidney disease., PMID:33107592
The Efficacy of the Mineralcorticoid Receptor Antagonist Canrenone in COVID-19 Patients., PMID:32933039
Preclinical study of simultaneous pharmacokinetic and pharmacodynamic herb-drug interactions between Yin-Chen-Hao-Tang and spironolactone., PMID:32799863
Ethanolic extract of Artemisia campestris subsp. glutinosa (Besser) Batt. inhibits HIV-1 replication in vitro through the activity of terpenes and flavonoids on viral entry and NF-κB pathway., PMID:32758575
Improved 11α-hydroxycanrenone production by modification of cytochrome P450 monooxygenase gene in Aspergillus ochraceus., PMID:32697747
Simultaneous determination of canrenone, digoxin and tolvaptan by UHPLC-MS/MS: application in heart failure patients., PMID:32469241
Assessment of adherence to diuretics and β-blockers by serum drug monitoring in comparison to urine analysis., PMID:32400211
Clinical efficacy of potassium canreonate-canrenone in sinus rhythm restoration among patients with atrial fibrillation - a protocol of a pilot, randomized, double -blind, placebo-controlled study (CANREN-AF trial)., PMID:32398047
Spironolactone metabolite concentrations in decompensated heart failure: insights from the ATHENA-HF trial., PMID:32237012
Effects of Mineralocorticoid and AT1 Receptor Antagonism on The Aldosterone-Renin Ratio In Primary Aldosteronism-the EMIRA Study., PMID:32067030
For research use only. Not for human or drug use.
