Catalog No.
AHJ79001
Biological activity
Measured by its ability of the immobilized protein to support the adhesion of human acute T cell leukemia cells (Jurkat). The ED50 for this effect is 0.250-2.50 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu72-Ala623
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9UKQ2
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
MDCL, MDC-L, Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II, Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L, ADAM 28, ADAM28, eMDC II, ADAM23, Disintegrin and metalloproteinase domain-containing protein 28
Research progress on ADAM28 in malignant tumors., PMID:40252142
ADAM28 promotes epithelial mesenchymal transition and impairs tight junctions in non-eosinophilic chronic rhinosinusitis with nasal polyps by inducing M1 polarization of macrophages., PMID:39954661
Extremely low-frequency electromagnetic field (ELF-EMF) induced alterations in gene expression and cytokine secretion in clear cell renal carcinoma cells., PMID:38717134
Differential Expressions of ADAM28 and ADAMTSL3 in Gingival Tissue of Patients with Periodontitis., PMID:36927684
Comparative transcriptome analysis in the caput segment of yak and cattleyak epididymis., PMID:36368116
LncRNA NEAT1 induces autophagy through the miR-128-3p/ADAM28 axis to suppress apoptosis of nonsmall-cell lung cancer., PMID:36054559
CD20+CD22+ADAM28+ B Cells in Tertiary Lymphoid Structures Promote Immunotherapy Response., PMID:35634306
Anatomical Transcriptome Atlas of the Male Mouse Reproductive System During Aging., PMID:35211476
CircRNA_100565 contributes to cisplatin resistance of NSCLC cells by regulating proliferation, apoptosis and autophagy via miR-337-3p/ADAM28 axis., PMID:33682697
ADAM28 from both endothelium and gastric cancer cleaves von Willebrand Factor to eliminate von Willebrand Factor-induced apoptosis of gastric cancer cells., PMID:33675784
[Construction of ADAM28 shRNA interference vector and its inhibitory effect on human periodontal ligament stem cells]., PMID:33543212
ADAM28: Another ambivalent protease in cancer., PMID:32861707
NELL2-mediated lumicrine signaling through OVCH2 is required for male fertility., PMID:32499443
The origin and diversification of a novel protein family in venomous snakes., PMID:32366667
Oncogenic ADAM28 induces gemcitabine resistance and predicts a poor prognosis in pancreatic cancer., PMID:31602160
Adamalysines as Biomarkers and a Potential Target of Therapy in Colorectal Cancer Patients: Preliminary Results., PMID:31565100
Effects of AIF-1 inflammatory factors on the regulation of proliferation of breast cancer cells., PMID:31389223
MiR-198 affects the proliferation and apoptosis of colorectal cancer through regulation of ADAM28/JAK-STAT signaling pathway., PMID:30840270
Possible Association between Cathepsin V and the Development of Placenta Accreta Spectrum Disorders., PMID:30759440
ADAM28 dramatically regulates the biological features of human gingival fibroblasts., PMID:30552542
ADAM28 promotes tumor growth and dissemination of acute myeloid leukemia through IGFBP-3 degradation and IGF-I-induced cell proliferation., PMID:30429106
Enhancer RNA and NFκB-dependent P300 regulation of ADAMDEC1., PMID:30352365
Selective Inhibition of ADAM28 Suppresses Lung Carcinoma Cell Growth and Metastasis., PMID:30190423
Epstein-Barr Virus Nuclear Antigen 3C Inhibits Expression of COBLL1 and the ADAM28-ADAMDEC1 Locus via Interaction with the Histone Lysine Demethylase KDM2B., PMID:30135119
Whole-genome scan reveals significant non-additive effects for sire conception rate in Holstein cattle., PMID:29486732
Serum levels of ADAM10, ADAM12, ADAM17 AND ADAM28 in colorectal cancer patients., PMID:29254295
ADAM-17 expression is enhanced by FoxM1 and is a poor prognostic sign in gastric carcinoma., PMID:29180185
CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells., PMID:28707394
ADAM28 localizes to HLA-G+ trophoblasts and promotes column cell outgrowth., PMID:28623976
The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice., PMID:28430139
Impact of male fertility status on the transcriptome of the bovine epididymis., PMID:28379507
Overexpression and knock-down studies highlight that a disintegrin and metalloproteinase 28 controls proliferation and migration in human prostate cancer., PMID:27749584
MicroRNA-552 enhances metastatic capacity of colorectal cancer cells by targeting a disintegrin and metalloprotease 28., PMID:27661126
Insights into the Evolution of a Snake Venom Multi-Gene Family from the Genomic Organization of Echis ocellatus SVMP Genes., PMID:27420095
Characterization of CD200 Ectodomain Shedding., PMID:27111430
ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death., PMID:26918856
EBNA3C Directs Recruitment of RBPJ (CBF1) to Chromatin during the Process of Gene Repression in EBV Infected B Cells., PMID:26751214
Imatinib reduces cholesterol uptake and matrix metalloproteinase activity in human THP-1 macrophages., PMID:26721343
Correction: ADAM28 Is Overexpressed in Human Breast Carcinomas: Implications for Carcinoma Cell Proliferation through Cleavage of Insulin-like Growth Factor Binding Protein-3., PMID:26471916
Identification of genes expressed in the migrating primitive myeloid lineage of Xenopus laevis., PMID:26264370
[The effects of ADAM28 AS-ODN on biological function of human gingival fibroblasts]., PMID:25543593
The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia., PMID:25453333
[Research advances on ADAM28 expression and ADAM28-mediated tumor metastasis]., PMID:25130845
IL-1β-induced matrix metalloproteinase-13 is activated by a disintegrin and metalloprotease-28-regulated proliferation of human osteoblast-like cells., PMID:24613731
Expressions of CLDN1 and insulin-like growth factor 2 are associated with poor prognosis in stage N2 non-small cell lung cancer., PMID:24112161
Modulation of enhancer looping and differential gene targeting by Epstein-Barr virus transcription factors directs cellular reprogramming., PMID:24068937
Src plays a key role in ADAM28 expression in v-src-transformed epithelial cells and human carcinoma cells., PMID:24007880
ADAM22 as a prognostic and therapeutic drug target in the treatment of endocrine-resistant breast cancer., PMID:23810013
Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression., PMID:23643150
Localization of the gene for hyperostosis cranialis interna to chromosome 8p21 with analysis of three candidate genes., PMID:23640157
For research use only. Not for human or drug use.
