Catalog No.
AHG78301
Biological activity
Measured by its ability to bind biotinylated Wnt-5a in a functional ELISA with an estimated Kd <5 nM.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln29-Leu168
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14332/Q9JIP6
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Frizzled-2, FzE2, Fz-2, hFz2, FZD2
Selective activation of FZD2 and FZD7 reveals non-redundant function during mesoderm differentiation., PMID:39824186
Craniofacial studies in chicken embryos confirm the pathogenicity of human FZD2 variants associated with Robinow syndrome., PMID:38967226
MiR-26b-3p Promotes Intestinal Motility Disorder by Targeting FZD10 to Inhibit GSK3β/β-Catenin Signaling and Induce Enteric Glial Cell Apoptosis., PMID:37728849
C. difficile intoxicates neurons and pericytes to drive neurogenic inflammation., PMID:37699522
FZD2 regulates limb development by mediating β-catenin-dependent and -independent Wnt signaling pathways., PMID:36867021
Successful therapeutic intervention in new mouse models of frizzled 2-associated congenital malformations., PMID:36789910
An epitope-directed selection strategy facilitating the identification of Frizzled receptor selective antibodies., PMID:36513066
Bioengineered BERA-Wnt5a siRNA Targeting Wnt5a/FZD2 Signaling Suppresses Advanced Prostate Cancer Tumor Growth and Enhances Enzalutamide Treatment., PMID:35930737
Ninjurin1 drives lung tumor formation and progression by potentiating Wnt/β-Catenin signaling through Frizzled2-LRP6 assembly., PMID:35395804
Integrated weighted gene coexpression network analysis identifies Frizzled 2 (FZD2) as a key gene in invasive malignant pleomorphic adenoma., PMID:34986855
Elevated Wnt2 and Wnt4 activate NF-κB signaling to promote cardiac fibrosis by cooperation of Fzd4/2 and LRP6 following myocardial infarction., PMID:34911029
Low-density lipoprotein receptor-related protein 1 is a CROPs-associated receptor for Clostridioides infection toxin B., PMID:34279819
Analysis of the role of Frizzled 2 in different cancer types., PMID:33565732
Pan-cancer analysis of the developmental pathways reveals non-canonical wnt signaling as a driver of mesenchymal-type tumors., PMID:32522670
Frizzled-2 small interfering RNA protects hepatic BRL-3A cells against Hypoxia / Reoxygenation via modulation of autophagy., PMID:32141827
Inhibition of Frizzled-2 by small interfering RNA protects rat hepatic BRL-3A cells against cytotoxicity and apoptosis induced by Hypoxia/Reoxygenation., PMID:31964521
Fzd2 Contributes to Breast Cancer Cell Mesenchymal-Like Stemness and Drug Resistance., PMID:31907106
FZD2 regulates cell proliferation and invasion in tongue squamous cell carcinoma., PMID:31595151
Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling., PMID:31530281
Wnt pathway markers in molecular subgroups of glioblastoma., PMID:31075260
Wnt Signaling Alterations in the Human Spinal Cord of Amyotrophic Lateral Sclerosis Cases: Spotlight on Fz2 and Wnt5a., PMID:30924074
Frizzled 2-induced epithelial-mesenchymal transition correlates with vasculogenic mimicry, stemness, and Hippo signaling in hepatocellular carcinoma., PMID:30677195
Structural basis for recognition of frizzled proteins by Clostridium difficile toxin B., PMID:29748286
Caveolin-1 down-regulation is required for Wnt5a-Frizzled 2 signalling in Ha-RasV12 -induced cell transformation., PMID:29502342
Nonsense mutations in FZD2 cause autosomal-dominant omodysplasia: Robinow syndrome-like phenotypes., PMID:29383834
Down-regulation of miR-30a-3p/5p promotes esophageal squamous cell carcinoma cell proliferation by activating the Wnt signaling pathway., PMID:29259372
[Relationship between Wound Age and the Expression of Fzd2 in Rats Skeletal Muscle after Contusion]., PMID:29219261
[Effect of Aralia echinocaulis containing serum on Wnt/β-catenin signaling pathway of primary osteoblast]., PMID:29098832
Slow freezing versus vitrification technique for human ovarian tissue cryopreservation: An evaluation of histological changes, WNT signaling pathway and apoptotic genes expression., PMID:28987775
Clinical implication of Frizzled 2 expression and its association with epithelial-to-mesenchymal transition in hepatocellular carcinoma., PMID:28350091
Homeobox, Wnt, and Fibroblast Growth Factor Signaling is Augmented During Alveogenesis in Mice Lacking Superoxide Dismutase 3, Extracellular., PMID:28220305
The Involvement of the Decrease of Astrocytic Wnt5a in the Cognitive Decline in Minimal Hepatic Encephalopathy., PMID:27878554
Promotion of epithelial-mesenchymal transition by Frizzled2 is involved in the metastasis of endometrial cancer., PMID:27373314
Frizzled2 signaling regulates growth of high-risk neuroblastomas by interfering with β-catenin-dependent and β-catenin-independent signaling pathways., PMID:27323822
Noncanonical WNT-5B signaling induces inflammatory responses in human lung fibroblasts., PMID:27036869
Wnt16 Signaling Is Required for IL-1β-Induced Matrix Metalloproteinase-13-Regulated Proliferation of Human Stem Cell-Derived Osteoblastic Cells., PMID:26861315
Suppression of hepatocellular carcinoma cell proliferation by short hairpin RNA of frizzled 2 with Sonazoid-enhanced irradiation., PMID:26648389
Frizzled2 mediates the migration and invasion of human oral squamous cell carcinoma cells through the regulation of the signal transducer and activator of transcription-3 signaling pathway., PMID:26398330
Wnt/β-Catenin and Wnt5a/Ca Pathways Regulate Proliferation and Apoptosis of Keratinocytes in Psoriasis Lesions., PMID:26202350
Jarid2 Coordinates Nanog Expression and PCP/Wnt Signaling Required for Efficient ESC Differentiation and Early Embryo Development., PMID:26190104
miR-203 Inhibits Frizzled-2 Expression via CD82/KAI1 Expression in Human Lung Carcinoma Cells., PMID:26132195
WNT5A inhibits hepatocyte proliferation and concludes β-catenin signaling in liver regeneration., PMID:26100214
Frizzled7 functions as a Wnt receptor in intestinal epithelial Lgr5(+) stem cells., PMID:25892522
A review of 1α,25(OH)2D3 dependent Pdia3 receptor complex components in Wnt5a non-canonical pathway signaling., PMID:25845934
A mutation in FRIZZLED2 impairs Wnt signaling and causes autosomal dominant omodysplasia., PMID:25759469
FZD2 inhibits the cell growth and migration of salivary adenoid cystic carcinomas., PMID:25695658
Gastric cancer cell proliferation is suppressed by frizzled-2 short hairpin RNA., PMID:25586465
A noncanonical Frizzled2 pathway regulates epithelial-mesenchymal transition and metastasis., PMID:25417160
Resveratrol attenuates hypoxia/reoxygenation‑induced Ca2+ overload by inhibiting the Wnt5a/Frizzled‑2 pathway in rat H9c2 cells., PMID:25120137
Wnt ligand/Frizzled 2 receptor signaling regulates tube shape and branch-point formation in the lung through control of epithelial cell shape., PMID:25114215
For research use only. Not for human or drug use.
