Catalog No.
AHJ58901
Biological activity
Immobilized human IL-36 beta /IL-1F8 at 2 µg/mL (100 µL/well), biotinylated recombinant human IL1RL2/IL-36R (Cat #: AHJ58901) binds with an ED50 of 1.50-15.0 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Asp20-Arg335
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9HB29
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL1R-rp2, IL1RL2, IL1RRP2, IL-1Rrp2, IL-36 receptor, Interleukin-1 receptor-related protein 2, Interleukin-1 receptor-like 2, IL-36R
IL1RAP Expression in Human Atherosclerosis: A Target of Novel Antibodies to Reduce Vascular Inflammation and Adhesion., PMID:40371594
Mendelian randomization analysis identifies ERAP1 and IL23R as potential drug targets for ankylosing spondylitis., PMID:40349828
Cardiorenal protective effects of Tanhuo decoction in acute myocardial infarction via regulating multi-target inflammation and metabolic signaling pathways., PMID:40242450
The G Protein-Coupled Receptor-Related Gene Signatures for Diagnosis and Prognosis in Glioblastoma: A Deep Learning Model Using RNA-Seq Data., PMID:39733410
Blocking IL1RAP on cancer-associated fibroblasts in pancreatic ductal adenocarcinoma suppresses IL-1-induced neutrophil recruitment., PMID:39694705
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
Vasopressin drives aberrant myeloid differentiation of hematopoietic stem cells, contributing to depression in mice., PMID:39442524
Efficacy and Safety of the Anti-IL1RAP Antibody Nadunolimab (CAN04) in Combination with Gemcitabine and Nab-Paclitaxel in Patients with Advanced/Metastatic Pancreatic Cancer., PMID:39385434
Casting NETs on Psoriasis: The modulation of inflammatory feedback targeting IL-36/IL-36R axis., PMID:39306890
IL1RL2 is related to the expression and prognosis of bladder cancer., PMID:39170626
IL1RAP-specific T cell engager depletes acute myeloid leukemia stem cells., PMID:39143574
Circ_0003314 Combines with the miR-26b-5p/IL1RAP Axis to Inhibit HTR-8/SVneo Cell Proliferation, Migration, Invasion and Tube Formation and Promote Apoptosis., PMID:39141177
Targeted proteomics involved in cardiovascular health and heart rate variability in children with overweight/obesity., PMID:38864311
Immune-related gene methylation prognostic instrument for stratification and targeted treatment of ovarian cancer patients toward advanced 3PM approach., PMID:38841623
Identification of plasma protein markers of allergic disease risk: a mendelian randomization approach to proteomic analysis., PMID:38773393
Floxed Il1rl2 Locus with mCherry Reporter Element Reveals Distinct Expression Patterns of the IL-36 Receptor in Barrier Tissues., PMID:38727323
Identification of potential drug targets for allergic diseases from a genetic perspective: A mendelian randomization study., PMID:38573314
Interleukin-1 receptor accessory protein blockade limits the development of atherosclerosis and reduces plaque inflammation., PMID:38563353
Causal relationship between inflammatory factors and cerebral small vessel disease: Univariate, multivariate, and summary-data-based mendelian randomization analysis., PMID:38340139
A liquid biomarker signature of inflammatory proteins accurately predicts early pancreatic cancer progression during FOLFIRINOX chemotherapy., PMID:38335839
IL-1R8 expression in DLBCL regulates NK cell recruitment and influences patient prognosis., PMID:37907630
Constitutive photomorphogenic protein 1 ubiquitinates interleukin-1 receptor accessory protein in human liver cancer., PMID:37700160
Candidate signatures of positive selection for environmental adaptation in indigenous African cattle: A review., PMID:37697736
CircCRIM1 mediates proliferation, migration, and invasion of trophoblast cell through regulating miR-942-5p/IL1RAP axis., PMID:37382169
Development of an immune-related gene prognostic risk model and identification of an immune infiltration signature in the tumor microenvironment of colon cancer., PMID:36890467
Interleukin-38 suppresses abdominal aortic aneurysm formation in mice by regulating macrophages in an IL1RL2-p38 pathway-dependent manner., PMID:36708509
Immune-related gene-based prognostic index for predicting survival and immunotherapy outcomes in colorectal carcinoma., PMID:36591255
IL1RAP Knockdown in LPS-Stimulated Normal Human Astrocytes Suppresses LPS-Induced Reactive Astrogliosis and Promotes Neuronal Cell Proliferation., PMID:36502418
Transcriptomic and functional analyses reveal a tumour-promoting role for the IL-36 receptor in colon cancer and crosstalk between IL-36 signalling and the IL-17/ IL-23 axis., PMID:36482185
Coated recombinant target protein helps explore IL-1RAP CAR T-cell functionality in vitro., PMID:36456721
IL1RAP is expressed in several subtypes of pediatric acute lymphoblastic leukemia and can be used as a target to eliminate ETV6::RUNX1-positive leukemia cells in preclinical models., PMID:36226493
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals., PMID:36171541
IL1RAP expression and the enrichment of IL-33 activation signatures in severe neutrophilic asthma., PMID:35986608
Innate immune mediator, Interleukin-1 receptor accessory protein (IL1RAP), is expressed and pro-tumorigenic in pancreatic cancer., PMID:35606824
Impact of smoking on cardiovascular risk and premature ageing: Findings from the STANISLAS cohort., PMID:35247627
Novel IL1RAP mutation associated with schizophrenia interferes with neuronal growth and related NF-κB signal pathways., PMID:35181481
Interleukin-1 Receptor-Like 2: One Receptor, Three Agonists, and Many Implications., PMID:35171706
Molecular Basis of Selective Cytokine Signaling Inhibition by Antibodies Targeting a Shared Receptor., PMID:35003094
First-in-human phase 1 dose-escalation study of CAN04, a first-in-class interleukin-1 receptor accessory protein (IL1RAP) antibody in patients with solid tumours., PMID:34903842
Circ_0037078 promotes trophoblast cell proliferation, migration, invasion and angiogenesis by miR-576-5p/IL1RAP axis., PMID:34724268
Gene signatures associated with barrier dysfunction and infection in oral lichen planus identified by analysis of transcriptomic data., PMID:34506598
IL-36γ and IL-36Ra Reciprocally Regulate NSCLC Progression by Modulating GSH Homeostasis and Oxidative Stress-Induced Cell Death., PMID:34369094
Proteomic and molecular evidences of Il1rl2, Ric8a, Krt18 and Hsp90b1 modulation during experimental hepatic fibrosis and pomegranate supplementation., PMID:34174316
Proteomic Screens for Suppressors of Anoikis Identify IL1RAP as a Promising Surface Target in Ewing Sarcoma., PMID:34021002
The Potential Role of IL1RAP on Tumor Microenvironment-Related Inflammatory Factors in Stomach Adenocarcinoma., PMID:33602046
Risk Variants in Three Alzheimer's Disease Genes Show Association with EEG Endophenotypes., PMID:33522999
IL-36 cytokines and gut immunity., PMID:33501638
Distinct Gene Expression Signatures Characterize Strong Clinical Responders Versus Nonresponders to Canakinumab in Children With Systemic Juvenile Idiopathic Arthritis., PMID:33452871
Structure-based Development of Human Interleukin-1β-Specific Antibody That Simultaneously Inhibits Binding to Both IL-1RI and IL-1RAcP., PMID:33359099
The IL1-IL1RAP axis plays an important role in the inflammatory leukemic niche that favors acute myeloid leukemia proliferation over normal hematopoiesis., PMID:33121233
For research use only. Not for human or drug use.
