Catalog No.
AMJ59401
Biological activity
Measured by its ability to enhance IFN-gamma secretion in human natural killer lymphoma cells (NK-92). The ED50 for this effect is 3-30 ng/mL.
Expression system
Mammalian Cells
Species
Mus musculus (Mouse)
Protein length
Pro25-Ser146
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9ES17
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-21, Interleukin-21, IL21, Za11, Drug Target
Note
For research use only.
Age-Associated B Cells in Autoimmune Diseases: Pathogenesis and Clinical Implications., PMID:39960645
Bidirectional Mendelian Randomization identifies plasma proteins associated with urticaria risk., PMID:39961865
Targeting γc family cytokines with biologics: current status and future prospects., PMID:39967341
CD8+ Regulatory T Cells Induced by Peptide Vaccination Ameliorates Experimental Model of Membranous Nephropathy., PMID:39970933
Characteristics and functions of interleukin 21 in channel catfish (Ictalurus punctatus)., PMID:39986549
Mendelian randomization reveals causal relationships between cytokines and male reproductive diseases., PMID:40023096
The saponin monophosphoryl lipid A nanoparticle adjuvant induces dose-dependent HIV vaccine responses in nonhuman primates., PMID:40036068
Cellular and molecular determinants mediating the dysregulated germinal center immune dynamics in systemic lupus erythematosus., PMID:40070830
Distinct features of a peripheral T helper subset that drives the B cell response in dengue virus infection., PMID:40073863
CD4 T cells take center stage during dengue infection., PMID:40073864
Therapy resistant hypertrophic lichen planus and its response to oral tofacitinib with a priori tissue cytokine expression: a real-world hospital-based study., PMID:40095121
JAK Inhibitors and B Cell Function: A Comparative Study of Their Impact on Plasma Cell Differentiation, Cytokine Production, and Naïve B Cell Activation., PMID:40098342
Plasma Cytokine and Chemokine Profiles Predict Efficacy and Toxicity of Anti-CD19 CAR-T Cell Therapy in Large B-Cell Lymphoma., PMID:40113544
Phenotypic and functional dysregulations of CD8 + T Cells in myasthenia gravis., PMID:40131529
Syndecans and glycosaminoglycans influence B-cell development and activation., PMID:40155751
Modulating IL-21-driven B cell responses in idiopathic inflammatory myopathies via inhibition of the JAK/STAT pathway., PMID:40170058
Functional insights of an uncommon hypomorphic variant in IL2RG as a monogenic cause of CVID-like disease with antibody deficiency and T CD4 lymphopenia., PMID:40170851
Attenuated Salmonella carrying IL-21 overexpression plasmid enhances radiotherapy efficacy in a preclinical model of melanoma., PMID:40174337
DNA scaffold-framed natural killer cell with programmed drug release for chemo-adoptive cell therapy., PMID:40180252
ICOS+CD4+ T cells define a high susceptibility to anti-PD-1 therapy-induced lung pathogenesis., PMID:40198121
Differential gut microbiota and inflammatory cytokines contribute to IgA vasculitis., PMID:40201970
Genetically druggable targets for MAPK-activated colorectal cancer by a two-sample mendelian randomization analysis., PMID:40210889
Polarization of Vδ2 T cells to a Th2-like phenotype promotes plasmablast differentiation and possesses pro-fibrotic properties in IgG4-related disease., PMID:40213561
A greater frequency of circulating CCR7loPD-1hi follicular helper T cells indicates a durable clinical cure after Peg IFN-α therapy in chronic hepatitis B patients., PMID:40227099
PD-L1+ Regulatory B Cells from Rheumatoid Arthritis Patients Have Impaired Function in Suppressing IFN-ү and IL-21 Production., PMID:40243636
Apolipoprotein A-I mediates function of follicular regulatory T cells and type 2 follicular helper T in allergic rhinitis., PMID:40260097
Correlation of the Expression Profile of Peripheral Leukocyte and Liver Tissue Immune Markers With Serum Liver Injury Indices in Children With Biliary Atresia., PMID:40270513
Andrographolide sulfonate alleviates rheumatoid arthritis by inhibiting glycolysis-mediated activation of PI3K/AKT to restrain Th17 cell differentiation., PMID:40274350
Tph cells are expanded in IgA vasculitis nephritis., PMID:40315784
The role of interleukin (IL)-2 cytokine family in Parkinson's disease., PMID:40318236
Serum Concentrations of IL-18, IL-21, IL-22, IL-23, IL-27, and IL-31 in Patients With Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis and Their Correlation With Disease Severity., PMID:40322299
Correlation among ocular surface changes and systemic hematologic indexes and disease activity in primary Sjögren's syndrome: a cross-sectional study., PMID:40329232
IL-21R-Targeted Nano-immunosuppressant Prevents Acute Rejection in Allogeneic Transplantation by Blocking Maturation of T Follicular Helper Cells., PMID:40339970
Amlexanox inhibits production of type I interferon and suppresses B cell differentiation in vitro: a possible therapeutic option for systemic lupus erythematosus and other systemic inflammatory diseases., PMID:40341181
Molecular characterization and expression analysis of IL-21 and its four receptor genes in yellow catfish (Pelteobagrus fulvidraco) in response to Edwardsiella ictaluri infection., PMID:40350105
Trifunctional antibody-cytokine fusion protein formats for tumor-targeted combination of IL-15 with IL-7 or IL-21., PMID:40370435
The effects of interleukin-21 in the biology of transplant rejection., PMID:40376002
Differential Expression of Th17-Related Cytokines in Patients of Chronic Kidney Disease with and Without Systemic Lupus Erythematosus., PMID:40407212
Increased Proportion of Circulating T Follicular Helper Cells and Serum Levels of IL-21 in Antibody-Mediated Rejection of Renal Allograft., PMID:40424492
Interleukin-37 Suppresses the Function of Type 2 Follicular Helper T in Allergic Rhinitis., PMID:40427088
A New Method of Canine CD4+ T Lymphocyte Differentiation Towards the Th17 Phenotype with Analysis of Properties and Mitochondrial Activity., PMID:40430086
Findings from transcriptomics and immunohistochemistry indicate an autoimmune disease targeting brainstem inhibitory interneurons in bovine spastic paresis., PMID:40440345
A critical role for IL-21/IL-21 receptor signaling in isoproterenol-induced cardiac remodeling., PMID:40447719
Anti-viral CD8 central memory veto cells as a new platform for CAR T cell therapy., PMID:40448965
IL-6R blockade combined with immunosuppressants alleviates adult-onset Still's disease through immune remodeling: a mass cytometry study., PMID:40457438
Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis., PMID:40458399
STAT3 inhibition mitigates experimental autoimmune gastritis by restoring Th17/Treg immune balance., PMID:40471463
Serum Levels of IL-21 and IL-27 Do not Reflect differential Avidity of Anti-SARS-CoV-2 IgG Antibodies in Symptomatic and Asymptomatic COVID-19 Patients., PMID:40471646
Higher frequencies of age-associated B-cells in early arthritis are linked to atherosclerosis and immune circuits-a potential role as a biomarker for risk stratification., PMID:40478777
Origin of Hypofunctional CD103+ NK Cells in Cirrhosis-Associated Ascites., PMID:40498379
For research use only. Not for human or drug use.
