Catalog No.
AHK15501
Biological activity
Measured by its ability to inhibit survival of human ovarian carcinoma cells (SK‑OV‑3). The ED50 for this effect is 1-5 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ala21-Gly663
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9C0C4
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SEMAI, SEMA4C, Semaphorin-4C, KIAA1739
Integrative analysis of semaphorins family genes in colorectal cancer: implications for prognosis and immunotherapy., PMID:40103807
Plexins: Navigating through the neural regulation and brain pathology., PMID:39756719
miR-129-2-3p binds SEMA4C to regulate HCC development and inhibit the EMT., PMID:39018715
Altered expression of the Plexin-B2 system in tuberous sclerosis complex and focal cortical dysplasia IIb lesions., PMID:38293776
Cleavage of semaphorin 4 C interferes with the neuroprotective effect of the semaphorin 4 C/Plexin B2 pathway on experimental intracerebral hemorrhage in rats., PMID:37482144
Computational ranking-assisted identification of Plexin-B2 in homotypic and heterotypic clustering of circulating tumor cells in breast cancer metastasis., PMID:37090580
Semaphorin 4C regulates ovarian steroidogenesis through RHOA/ROCK1-mediated actin cytoskeleton rearrangement., PMID:36892447
Sema4C Is Required for Vascular and Primary Motor Neuronal Patterning in Zebrafish., PMID:36010604
Plexin-B2 and Semaphorins Do Not Drive Rhabdomyosarcoma Proliferation or Migration., PMID:35570846
The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis., PMID:35402068
MicroRNA-22 coordinates vascular and motor neuronal pathfinding via sema4 during zebrafish development., PMID:35382569
Semaphorin 4C promotes motility and immunosuppressive activity of cancer cells via CRMP3 and PD-L1., PMID:35261797
Effect of microrna-138 on epithelial-Mesenchymal transition and invasion of breast cancer cells by targeting semaphorin 4C., PMID:34747314
Serum semaphorin 4C as a diagnostic biomarker in breast cancer: A multicenter retrospective study., PMID:34738326
Receptor-driven invasion profiles in diffuse intrinsic pontine glioma., PMID:34013206
Whole-Transcriptome Profiling of Human Heart Tissues Reveals the Potential Novel Players and Regulatory Networks in Different Cardiomyopathy Subtypes of Heart Failure., PMID:33517678
Plexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics., PMID:33514835
Long non-coding RNA TDRG1 promotes hypoxia-induced glycolysis by targeting the miR-214-5p/SEMA4C axis in cervical cancer cells., PMID:33394293
High SEMA4C expression promotes the epithelial-mesenchymal transition and predicts poor prognosis in colorectal carcinoma., PMID:33177246
Hsa-miR-10a-5p promotes pancreatic cancer growth by BDNF/SEMA4C pathway., PMID:32683841
Semaphorin 4A, 4C, and 4D: Function comparison in the autoimmunity, allergy, and cancer., PMID:32244055
Mechanism of cargo recognition by retromer-linked SNX-BAR proteins., PMID:32150533
Downregulation of SEMA4C Inhibit Epithelial-Mesenchymal Transition (EMT) and the Invasion and Metastasis of Cervical Cancer Cells via Inhibiting Transforming Growth Factor-beta 1 (TGF-β1)-Induced Hela cells p38 Mitogen-Activated Protein Kinase (MAPK) Activation., PMID:31951596
The microRNA‑708‑5p/ZEB1/EMT axis mediates the metastatic potential of osteosarcoma., PMID:31894343
Sema4C mediates EMT inducing chemotherapeutic resistance of miR-31-3p in cervical cancer cells., PMID:31776419
SEMA4C is a novel target to limit osteosarcoma growth, progression, and metastasis., PMID:31582836
The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology., PMID:31444474
Reverse signaling by semaphorin 4C elicits SMAD1/5- and ID1/3-dependent invasive reprogramming in cancer cells., PMID:31431542
Semaphorin 4C Promotes Macrophage Recruitment and Angiogenesis in Breast Cancer., PMID:31308149
Sema4C/PlexinB2 signaling controls breast cancer cell growth, hormonal dependence and tumorigenic potential., PMID:29555978
Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain., PMID:28765520
Plexin B2 and Semaphorin 4C Guide T Cell Recruitment and Function in the Germinal Center., PMID:28467912
Semaphorin 4C Protects against Allergic Inflammation: Requirement of Regulatory CD138+ Plasma Cells., PMID:27881703
miR-25-3p reverses epithelial-mesenchymal transition via targeting Sema4C in cisplatin-resistance cervical cancer cells., PMID:27743413
Tumor-associated Lymphatic Endothelial Cells Promote Lymphatic Metastasis By Highly Expressing and Secreting SEMA4C., PMID:27401250
MiR-138 inhibits cell proliferation and reverses epithelial-mesenchymal transition in non-small cell lung cancer cells by targeting GIT1 and SEMA4C., PMID:26283050
Plexin-B2 promotes invasive growth of malignant glioma., PMID:25762646
MiR-125b regulates epithelial-mesenchymal transition via targeting Sema4C in paclitaxel-resistant breast cancer cells., PMID:25605244
Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy., PMID:25193853
Adipocytokine expression associated with miRNA regulation and diagnosis of NASH in obese patients with NAFLD., PMID:24684403
Erbin interacts with Sema4C and inhibits Sema4C-induced epithelial-mesenchymal transition in HK2 cells., PMID:24142719
The Plexin-B family and its role in cancer progression., PMID:24043639
Functional proteomics, human genetics and cancer biology of GIPC family members., PMID:23743496
[Expression and clinical significance of Sema4C in esophageal cancer, gastric cancer and rectal cancer]., PMID:22944267
Branching morphogenesis: from individual molecules to a systems biology approach: commentary on "Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney" by Perälä et al., PMID:21168258
Semaphorin 4C and 4G are ligands of Plexin-B2 required in cerebellar development., PMID:21122816
Sema4C-Plexin B2 signalling modulates ureteric branching in developing kidney., PMID:21035938
Role of Sema4C in TGF-β1-induced mitogen-activated protein kinase activation and epithelial-mesenchymal transition in renal tubular epithelial cells., PMID:20959347
A systematic expression analysis implicates Plexin-B2 and its ligand Sema4C in the regulation of the vascular and endocrine system., PMID:20478304
Sema4C expression in neural stem/progenitor cells and in adult neurogenesis induced by cerebral ischemia., PMID:19189244
For research use only. Not for human or drug use.
