Catalog No.
AHJ42801
Biological activity
Measured by its ability to inhibit the G-CSF induced proliferation of mouse myelogenous leukemia lymphoblast cells (MNFS-60). The ED50 for this ettect is typically 31.5-126 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu25-Pro621
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q99062
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
G-CSF receptor, CSF3R, GCSFR, G-CSF-R, CD114, Granulocyte colony-stimulating factor receptor
Note
For research use only.
Novel technique for the direct flow cytofluorometric analysis of human basophils in unseparated blood and bone marrow, and the characterization of phenotype and peroxidase of human basophils., PMID:10082306
Decreased apoptosis and increased activation of alveolar neutrophils in bacterial pneumonia., PMID:10858402
Endotoxin down-modulates granulocyte colony-stimulating factor receptor (CD114) on human neutrophils., PMID:10882621
Granulocyte colony-stimulating factor (G-CSF) downregulates its receptor (CD114) on neutrophils and induces gelatinase B release in humans., PMID:11091218
Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies., PMID:14962246
[The response of bone marrow hematopoietic cells to G-CSF in paroxysmal nocturnal hemoglobinuria patients]., PMID:15949269
Neutrophil apoptosis, activation and anti-inflammatory cytokine response in granulocyte colony-stimulating factor-treated patients with community-acquired pneumonia., PMID:16369129
Activation of critical, host-induced, metabolic and stress pathways marks neutrophil entry into cystic fibrosis lungs., PMID:19293384
Isolation and characterization of stem cells from the human parathyroid gland., PMID:19489980
Neutrophil hyperchemotaxis in Behçet's disease: a possible role for monocytes orchestrating bacterial-induced innate immune responses., PMID:19701803
Transcriptional profiling reveals developmental relationship and distinct biological functions of CD16+ and CD16- monocyte subsets., PMID:19712453
Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study., PMID:20185904
Expression of CD123 and CD114 on the bone marrow cells of patients with myelodysplastic syndrome., PMID:20819538
C/EBPα and PU.1 are involved in distinct differentiation responses of acute promyelocytic leukemia HL-60 and NB4 cells via chromatin remodeling., PMID:20864248
Physicochemical and biologic comparability of a biosimilar granulocyte colony-stimulating factor with its reference product., PMID:20873878
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments., PMID:21357764
Defective leukocyte GM-CSF receptor (CD116) expression and function in inflammatory bowel disease., PMID:21557945
G-CSF receptor positive neuroblastoma subpopulations are enriched in chemotherapy-resistant or relapsed tumors and are highly tumorigenic., PMID:23687340
GCSF-R expression in myelodysplastic and myeloproliferative disorders and blast dysmaturation in CML., PMID:23897249
In vivo Lineage-tracing Studies in a Cancer Stem Cell Population in Neuroblastoma., PMID:27540563
CD114 Expression Mediates Melanoma Tumor Cell Growth and Treatment Resistance., PMID:26124323
Expressions of CD96 and CD123 in Bone Marrow Cells of Patients with Myelodysplastic Syndromes., PMID:26642704
CD114: A New Member of the Neural Crest-Derived Cancer Stem Cell Marker Family., PMID:27428599
Direct anti-inflammatory effects of granulocyte colony-stimulating factor (G-CSF) on activation and functional properties of human T cell subpopulations in vitro., PMID:29357983
Role of the angiotensin-converting enzyme in the G-CSF-induced mobilization of progenitor cells., PMID:29549541
Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus., PMID:29868014
CSF3R/CD114 mediates infection-dependent transition to severe asthma., PMID:30312710
Establishment and characterization of two head kidney macrophage cell lines from large yellow croaker (Larimichthys crocea)., PMID:31470020
Roniciclib down-regulates stemness and inhibits cell growth by inducing nucleolar stress in neuroblastoma., PMID:32737364
Delineation of target expression profiles in CD34+/CD38- and CD34+/CD38+ stem and progenitor cells in AML and CML., PMID:33085758
Specific circulating neutrophils subsets are present in clinically stable adults with cystic fibrosis and are further modulated by pulmonary exacerbations., PMID:36248793
Gene Expression of CSF3R/CD114 Is Associated with Poorer Patient Survival in Glioma., PMID:38474265
For research use only. Not for human or drug use.
