Catalog No.
AHK84801
Biological activity
Measured by its ability to synergize with Wnt-3a to induce Topflash reporter activity in human embryonic kidney cells (HEK293T). The ED50 for this effect is 10-40 ng/mL in the presence of 20 ng/mL of recombinant mouse Wnt‑3a.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu25-Cys295
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q96HF1
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SARP-1, Secreted frizzled-related protein 2, Secreted apoptosis-related protein 1, sFRP-2, FRP-2, SARP1, FRP2, SFRP2
Creb5 controls its own expression and directly induces the joint interzone regulatory program., PMID:40472036
SFRP1 and SFRP2 jointly regulate normal and malignant hematopoietic progenitors by influencing mesenchymal cells in the hematopoietic niche., PMID:40446746
Evolutionary and Structural Assessment of the Human Secreted Frizzled-Related Protein (SFRP) Family., PMID:40372458
Stromal barriers to the abscopal effect., PMID:40359907
Vaccarin treats lactation insufficiency through the ALKBH5-SFRP2-Wnt/β-catenin signaling pathway., PMID:40311715
Alpha-smooth muscle actin-expressing dermal sheath cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophy., PMID:40256763
LncRNA H19 inhibited dermal papilla cell senescence process through miR-29a by targeting Wnt/β-catenin signaling pathway., PMID:40204984
Tumour-intrinsic alterations and stromal matrix remodelling promote Wnt-niche independence during diffuse-type gastric cancer progression., PMID:40169243
Understanding psoriatic disease at single-cell resolution: an update., PMID:40160177
FoxO3 controls cardiomyocyte proliferation and heart regeneration by regulating Sfrp2 expression in postnatal mice., PMID:40087279
PAI-1-driven SFRP2high cancer-associated fibroblasts hijack the abscopal effect of radioimmunotherapy., PMID:40086438
Differential cellular origins of the extracellular matrix of tumor and normal tissues according to colorectal cancer subtypes., PMID:40032993
SFRP2 mediates Epstein-Barr virus and bladder cancer risk: a Mendelian randomization study and colocalization analysis., PMID:40016549
Circulating SFRP2 in Iranian Polycystic Ovarian Syndrome Patients with Infertility and Recurrent Pregnancy Loss and its Correlation with Insulin Resistance and Inflammation., PMID:39945268
Single-cell and spatial-resolved profiling reveals cancer-associated fibroblast heterogeneity in colorectal cancer metabolic subtypes., PMID:39934919
Decoding SFRP2 progenitors in sustaining tooth growth at single-cell resolution., PMID:39920788
Molecular Profiling of Odontoclasts during Physiological Tooth Replacement., PMID:39876039
Integrated single-cell RNA sequencing reveals the tumor heterogeneity and microenvironment landscape during liver metastasis in adenocarcinoma of esophagogastric junction., PMID:39850884
Expression, prognosis, immunological infiltration, and DNA methylation of members of the SFRP gene family in colorectal cancer: a comparative bioinformatic and experimental analysis., PMID:39729237
Combining methylated RNF180 and SFRP2 plasma biomarkers for noninvasive diagnosis of gastric cancer., PMID:39541711
Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice., PMID:39535658
SFRP2 modulates functional phenotype transition and energy metabolism of macrophages during diabetic wound healing., PMID:39464880
Teatime: epigallocatechin gallate targets fibroblast-epithelial cell crosstalk to combat lung fibrosis., PMID:39286980
Skin fibrosis is accompanied by increased expression of secreted frizzled-related protein-2., PMID:39157888
A primate-specific endogenous retroviral envelope protein sequesters SFRP2 to regulate human cardiomyocyte development., PMID:39146934
The screening of α-glucosidase inhibitory peptides from β-conglycinin and hypoglycemic mechanism in HepG2 cells and zebrafish larvae., PMID:39137852
Increased Secreted Frizzled-Related Protein 2 in Hypertension-Induced Left Ventricular Remodeling., PMID:39076470
Dynamic Transcriptome Analysis of SFRP Family in Guided Bone Regeneration With Occlusive Periosteum in Swine Model., PMID:39042069
Atypical chemokine receptor 1-positive endothelial cells mediate leucocyte infiltration and synergize with secreted frizzled-related protein 2/asporin-positive fibroblasts to promote skin fibrosis in systemic sclerosis., PMID:39009432
A fibroblast-dependent TGF-β1/sFRP2 noncanonical Wnt signaling axis promotes epithelial metaplasia in idiopathic pulmonary fibrosis., PMID:38980870
Hair follicle-resident progenitor cells are a major cellular contributor to heterotopic subcutaneous ossifications in a mouse model of Albright hereditary osteodystrophy., PMID:38948860
[Cuiru Keli Improves Postpartum Hypogalactia in Rats Through Secreted Frizzled-Related Protein 2-Wnt/β-catenin Signaling Pathway]., PMID:38948275
Genetic polymorphisms linked to extreme postorthodontic external apical root resorption in Koreans., PMID:38853224
Comprehensive transcriptome profiling between balding and non-balding scalp of female pattern hair loss in Asian., PMID:38850442
Down-regulation of RTEL1 Improves M1/M2 Macrophage Polarization by Promoting SFRP2 in Fibroblasts-derived Exosomes to Alleviate COPD., PMID:38805113
Identification of epigenetic silencing of the SFRP2 gene in colorectal cancer as a clinical biomarker and molecular significance., PMID:38802858
Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer., PMID:38657117
Proteomic Profiling of Central Centrifugal Cicatricial Alopecia Reveals Role of Humoral Immune Response Pathway and Metabolic Dysregulation., PMID:38585195
RNA Sequencing Reveals the Inhibitory Effect of High Levels of Arachidonic Acid and Linoleic Acid on C2C12 Differentiation and Myogenic Biomarkers., PMID:38474834
Soluble Frizzled-related proteins promote exosome-mediated Wnt re-secretion., PMID:38429359
SFRP2 suppresses trophoblast cell migration by inhibiting the Wnt/β‑catenin pathway., PMID:38426532
ChIP-Seq analysis reveals PRKACB as a target gene of HOXC13 involved in rabbit hair follicle development., PMID:38381512
AHRR and SFRP2 in primary versus recurrent high-grade serous ovarian carcinoma and their prognostic implication., PMID:38361045
Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease., PMID:38358820
Single-cell analysis reveals ADGRL4+ renal tubule cells as a highly aggressive cell type in clear cell renal cell carcinoma., PMID:38287102
Molecular prognostic of nine parthanatos death-related genes in glioma, particularly in COL8A1 identification., PMID:38225203
Expression of secreted frizzled-related proteins in acute aortic dissection patients and the effects on prognosis., PMID:38188253
Circulating cell-free DNA methylation patterns as non-invasive biomarkers to monitor colorectal cancer treatment efficacy without referencing primary site mutation profiles., PMID:38172877
Characterization of Wnt signaling pathway under treatment of Lactobacillus acidophilus postbiotic in colorectal cancer using an integrated in silico and in vitro analysis., PMID:38151510
Whole-transcriptome defines novel glucose metabolic subtypes in colorectal cancer., PMID:38116696
For research use only. Not for human or drug use.
