Catalog No.
AHK23201
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human TL1A/TNFSF15 is immobilized at 2 μg/mL (100 μL/well), recombinant human TNFRSF25/DR3 (Cat #: AHK23201) binds with an ED50 of less than 2.40 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln25-Gln199
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q93038
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Apoptosis-inducing receptor AIR, Apoptosis-mediating receptor DR3, Apoptosis-mediating receptor TRAMP, Protein WSL-1, LARD, Lymphocyte-associated receptor of death, Tumor necrosis factor receptor superfamily member 25, Apo-3, Protein WSL, APO3, DR3, TNFRSF12, WSL, TNFRSF25, Death receptor 3, DDR3, WSL1
Note
For research use only.
P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice., PMID:31592235
Lower nucleus accumbens α-synuclein load and D3 receptor levels in Parkinson's disease with impulsive compulsive behaviours., PMID:31603207
Syndecan 4, galectin 2, and death receptor 3 (DR3) as novel proteins in pathophysiology of preeclampsia., PMID:31608721
The TL1A-DR3 Axis Selectively Drives Effector Functions in Human MAIT Cells., PMID:31628153
Hippocampal TNF-death receptors, caspase cell death cascades, and IL-8 in alcohol use disorder., PMID:32139808
The Role of TNFR2 and DR3 in the In Vivo Expansion of Tregs in T Cell Depleting Transplantation Regimens., PMID:32397343
Prostate Epithelial RON Signaling Promotes M2 Macrophage Activation to Drive Prostate Tumor Growth and Progression., PMID:32439702
Molecular signature of slowly expanding lesions in progressive multiple sclerosis., PMID:32577755
The Role of the TL1A/DR3 Axis in the Activation of Group 2 Innate Lymphoid Cells in Subjects with Eosinophilic Asthma., PMID:32584596
Rosmarinic acid-induced apoptosis and cell cycle arrest in triple-negative breast cancer cells., PMID:32750370
Association between prenatal bisphenol a exposure and promoter hypermethylation of CAPS2, TNFRSF25, and HKR1 genes in cord blood., PMID:32763279
TNFSF15 Promotes Antimicrobial Pathways in Human Macrophages and These Are Modulated by TNFSF15 Disease-Risk Variants., PMID:32827707
DR3 stimulation of adipose resident ILC2s ameliorates type 2 diabetes mellitus., PMID:32948777
Direct signaling of TL1A-DR3 on fibroblasts induces intestinal fibrosis in vivo., PMID:33097818
TL1A-DR3 Plasma Levels Are Predictive of HIV-1 Disease Control, and DR3 Costimulation Boosts HIV-1-Specific T Cell Responses., PMID:33177161
Role of Myeloid-Derived Suppressor Cells in High-Dose-Irradiated TRAMP-C1 Tumors: A Therapeutic Target and an Index for Assessing Tumor Microenvironment., PMID:33188861
Multiplex gene targeting in the mouse embryo using a Cas9-Cpf1 hybrid guide RNA., PMID:33421768
Aberrant Hypermethylation-Mediated Suppression of PYCARD Is Extremely Frequent in Prostate Cancer with Gleason Score ≥ 7., PMID:33628338
Host versus cell-dependent effects of β-arrestin 1 expression in prostate tumorigenesis., PMID:33710266
Use of Post-transplant Cyclophosphamide Treatment to Build a Tolerance Platform to Prevent Liquid and Solid Organ Allograft Rejection., PMID:33737937
Targeting TL1A/DR3 Signaling Offers a Therapeutic Advantage to Neutralizing IL13/IL4Rα in Muco-Secretory Fibrotic Disorders., PMID:34305924
Aqueous metabolome of tissue-specific conditional Pten-knockout mouse prostate cancer and TRAMP neuroendocrine carcinoma., PMID:34662447
Roles for ADAM17 in TNF-R1 Mediated Cell Death and Survival in Human U937 and Jurkat Cells., PMID:34831323
Co-Expression and Functional Interactions of Death Receptor 3 and E-Selectin in Clear Cell Renal Cell Carcinoma., PMID:35063404
Energy Metabolism-Related Gene Prognostic Index Predicts Biochemical Recurrence for Patients With Prostate Cancer Undergoing Radical Prostatectomy., PMID:35280985
TL1A/DR3 Axis, A Key Target of TNF-a, Augments the Epithelial-Mesenchymal Transformation of Epithelial Cells in OVA-Induced Asthma., PMID:35359966
Stress and the brain transcriptome: Identifying commonalities and clusters in standardized data from published experiments., PMID:35405299
Pancreatic islet transplantation in type 1 diabetes: 20-year experience from a single-centre cohort in Canada., PMID:35588757
Role of TL1A in Inflammatory Autoimmune Diseases: A Comprehensive Review., PMID:35911746
Prognosis Analysis and Validation of Fatty Acid Metabolism-Related lncRNAs and Tumor Immune Microenvironment in Cervical Cancer., PMID:35942212
Meloxicam Inhibits Apoptosis in Neurons by Deactivating Tumor Necrosis Factor Receptor Superfamily Member 25, Leading to the Decreased Cleavage of DNA Fragmentation Factor Subunit α in Alzheimer's Disease., PMID:36279100
Diagnostic, prognostic, and immunological roles of CD177 in cervical cancer., PMID:36352147
Impact of BSG/CD147 gene expression on diagnostic, prognostic and therapeutic strategies towards malignant cancers and possible susceptibility to SARS-CoV-2., PMID:36574092
The cytokine receptor DR3 identifies and promotes the activation of thymic NKT17 cells., PMID:36847849
Membrane tension-mediated stiff and soft tumor subtypes closely associated with prognosis for prostate cancer patients., PMID:37179366
Identification of a novel role for TL1A/DR3 deficiency in acute respiratory distress syndrome that exacerbates alveolar epithelial disruption., PMID:37434162
Tumor necrosis factor-like cytokine 1A plays a role in inflammatory bowel disease pathogenesis., PMID:37579137
The ever-expanding role of cytokine receptor DR3 in T cells., PMID:38359559
DR6 Augments Colorectal Cancer Cell Growth, Invasion, and Stemness by Activating AKT/NF-κB Pathway., PMID:38478147
TL1A priming induces a multi-cytokine Th9 cell phenotype that promotes robust allergic inflammation in murine models of asthma., PMID:38493956
Transcriptomic analysis reveals the critical role of chemokine signaling in the anti-atherosclerosis effect of Xuefu Zhuyu decoction., PMID:38679399
An In Vitro Study on the Cytotoxic, Antioxidant, and Antimicrobial Properties of Yamogenin-A Plant Steroidal Saponin and Evaluation of Its Mechanism of Action in Gastric Cancer Cells., PMID:38731847
Anti-TL1A monoclonal antibody modulates the dysregulation of Th1/Th17 cells and attenuates granuloma formation in sarcoidosis by inhibiting the PI3K/AKT signaling pathway., PMID:38852524
Targeting TNFRSF25 by agonistic antibodies and multimeric TL1A proteins co-stimulated CD8+ T cells and inhibited tumor growth., PMID:39142717
Targeting TL1A and DR3: the new frontier of anti-cytokine therapy in IBD., PMID:39266053
Identification and Validation of Epithelial Cell Centre Regulatory Transcription Factors in the Gastric Cancer Microenvironment., PMID:39759895
The TL1A inhibitors in IBD: what's in the pot?, PMID:39772947
Effects of dioscin from Dioscorea nipponica on TL1A/DR3 and Th9 cells in a collagen-induced arthritis mouse model., PMID:39798473
Pretransplant targeting of TNFRSF25 and CD25 stimulates recipient Tregs in target tissues ameliorating GVHD post-HSCT., PMID:39896683
TL1A, a novel alarmin in airway, intestinal, and autoimmune disorders., PMID:40010414
For research use only. Not for human or drug use.
