Catalog No.
AHN56701
Biological activity
Measured by its ability to transfer sulfate from PAPS to chondroitin sulfate. The specific activity is >100 pmol/min/μg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser99-Thr561
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q7LFX5
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
GALNAC4S6ST, N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase, KIAA0598, BRAG, B-cell RAG-associated gene protein, hBRAG, CHST15, GalNAc4S-6ST, Carbohydrate sulfotransferase 15
Mendelian randomization analysis of plasma proteins reveals potential novel tumor markers for gastric cancer., PMID:39875498
Structural and mechanism-based engineering of sulfotransferase CHST15 for the efficient synthesis of chondroitin sulfate E., PMID:39629983
SARS-CoV-2 spike protein-ACE2 interaction increases carbohydrate sulfotransferases and reduces N-acetylgalactosamine-4-sulfatase by p38 MAPK., PMID:38355690
A proteomic analysis of atrial fibrillation in a prospective longitudinal cohort (AGES-Reykjavik study)., PMID:37967346
Unveiling the key genes, environmental toxins, and drug exposures in modulating the severity of ulcerative colitis: a comprehensive analysis., PMID:37539055
Inhibition of Astrocytic Carbohydrate Sulfotransferase 15 Promotes Nerve Repair After Spinal Cord Injury via Mitigation of CSPG Mediated Axonal Inhibition., PMID:36913114
Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population., PMID:36608057
CHST15 gene germline mutation is associated with the development of familial myeloproliferative neoplasms and higher transformation risk., PMID:35798703
[Effect and mechanism of glucocorticoids in preventing stenosis after esophageal endoscopic submucosal dissection]., PMID:35692065
Chondroitin sulfate proteoglycan 4,6 sulfation regulates sympathetic nerve regeneration after myocardial infarction., PMID:35604022
Circular RNA Signatures of Human Healing and Nonhealing Wounds., PMID:35429518
Adherence of Candida albicans and Malassezia Species to Skin Cells Induces Changes in the Expression of Genes Responsible for Heparan and Chondroitin Sulfate Chain Synthesis., PMID:35331724
Glycogenes in Oncofetal Chondroitin Sulfate Biosynthesis are Differently Expressed and Correlated With Immune Response in Placenta and Colorectal Cancer., PMID:34966741
circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis., PMID:34922539
Increase in Chondroitin Sulfate and Decline in Arylsulfatase B May Contribute to Pathophysiology of COVID-19 Respiratory Failure., PMID:34788765
Exploring the sulfate patterns of chondroitin sulfate/dermatan sulfate and keratan sulfate in human pancreatic cancer., PMID:34464868
An epigenome-wide DNA methylation study of patients with COVID-19., PMID:34185889
Genome-Wide Analyses Reveal Genetic Convergence of Prolificacy between Goats and Sheep., PMID:33810234
Protective effect of chondroitin sulfate nano-selenium on chondrocyte of patients with Kashin-Beck disease., PMID:33487067
Protein-membrane interactions in small GTPase signalling and pharmacology: perspectives from Arf GTPases studies., PMID:33336699
Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice., PMID:33143303
Protective Role of Optineurin Against Joint Destruction in Rheumatoid Arthritis Synovial Fibroblasts., PMID:32307918
CHST15 promotes the proliferation of TE‑1 cells via multiple pathways in esophageal cancer., PMID:31746400
Serious Selenium Deficiency in the Serum of Patients with Kashin-Beck Disease and the Effect of Nano-Selenium on Their Chondrocytes., PMID:31175635
Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15., PMID:30963568
PH-domain-binding inhibitors of nucleotide exchange factor BRAG2 disrupt Arf GTPase signaling., PMID:30742123
Tumor-dependent Effects of Proteoglycans and Various Glycosaminoglycan Synthesizing Enzymes and Sulfotransferases on Patients' Outcome., PMID:29984655
Oligonucleotide-Based Therapies for Inflammatory Bowel Disease., PMID:29948918
BRAF-mutant colorectal cancer, a different breed evolving., PMID:29708446
Variants in chondroitin sulfate metabolism genes in thrombotic storm., PMID:29178990
Effects of EUS-guided intratumoral injection of oligonucleotide STNM01 on tumor growth, histology, and overall survival in patients with unresectable pancreatic cancer., PMID:29122598
Discovery of a Small-Molecule Modulator of Glycosaminoglycan Sulfation., PMID:29099173
Silencing of Carbohydrate Sulfotransferase 15 Hinders Murine Pulmonary Fibrosis Development., PMID:28325283
Prevention of esophageal stricture after endoscopic submucosal dissection using RNA-based silencing of carbohydrate sulfotransferase 15 in a porcine model., PMID:28264215
Phase 1 Clinical Study of siRNA Targeting Carbohydrate Sulphotransferase 15 in Crohn's Disease Patients with Active Mucosal Lesions., PMID:27484097
Prognostic significance of highly sulfated chondroitin sulfates in ovarian cancer defined by the single chain antibody GD3A11., PMID:26731725
Inhibition of Cell Proliferation and Growth of Pancreatic Cancer by Silencing of Carbohydrate Sulfotransferase 15 In Vitro and in a Xenograft Model., PMID:26642349
Prognostic impact of chondroitin-4-sulfotransferase CHST11 in ovarian cancer., PMID:26084610
Chondroitin / dermatan sulfate modification enzymes in zebrafish development., PMID:25793894
Small interfering RNA therapy against carbohydrate sulfotransferase 15 inhibits cardiac remodeling in rats with dilated cardiomyopathy., PMID:25778904
Role for chondroitin sulfate glycosaminoglycan in NEDD9-mediated breast cancer cell growth., PMID:25445787
EFA6 controls Arf1 and Arf6 activation through a negative feedback loop., PMID:25114232
Changes in the metabolism of chondroitin sulfate glycosaminoglycans in articular cartilage from patients with Kashin-Beck disease., PMID:24857976
Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells., PMID:24085844
LC-MS and LC-MS/MS studies of incorporation of 34SO3 into glycosaminoglycan chains by sulfotransferases., PMID:23696150
Headbobber: a combined morphogenetic and cochleosaccular mouse model to study 10qter deletions in human deafness., PMID:23457544
Arf6-GEF BRAG1 regulates JNK-mediated synaptic removal of GluA1-containing AMPA receptors: a new mechanism for nonsyndromic X-linked mental disorder., PMID:22915114
Detection of specific glycosaminoglycans and glycan epitopes by in vitro sulfation using recombinant sulfotransferases., PMID:21169395
Antibody GD3G7 selected against embryonic glycosaminoglycans defines chondroitin sulfate-E domains highly up-regulated in ovarian cancer and involved in vascular endothelial growth factor binding., PMID:17717144
Human N-acetylgalactosamine 4-sulfate 6-O-sulfotransferase cDNA is related to human B cell recombination activating gene-associated gene., PMID:11572857
For research use only. Not for human or drug use.
