Catalog No.
AHB96301
Biological activity
Measured by its ability to inhibit anti-CD3 antibody induced IFN-gamma secretion by human peripheral blood mononuclear cells (PBMC). The ED50 for this effect is 1-6 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu21-Glu186
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q71H61
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Immunoglobulin-like domain-containing receptor 2, ILDR2, C1orf32
The role of the tricellular junction protein ILDR2 in glomerulopathies: Expression patterns and functional insights., PMID:39640577
Sublingual macrophage-associated ILDR2 contributes to immune tolerance via Treg induction., PMID:39626366
Bicellular Localization of Tricellular Junctional Protein Angulin-3/ILDR2 Allows Detection of Podocyte Injury., PMID:38311119
Expression analysis of inhibitory B7 family members in Alzheimer's disease., PMID:37665469
Mapping of the podocin proximity-dependent proteome reveals novel components of the kidney podocyte foot process., PMID:37325559
Marine Fish Protein Peptide Regulating Potassium Oxonate-Induced Intestinal Dysfunction in Hyperuricemia Rats Helps Alleviate Kidney Inflammation., PMID:36530149
Integrating knowledge of protein sequence with protein function for the prediction and validation of new MALT1 substrates., PMID:36147669
The Positive and Negative Immunoregulatory Role of B7 Family: Promising Novel Targets in Gastric Cancer Treatment., PMID:34639059
ILDR2 stabilization is regulated by its interaction with GRP78., PMID:33863978
The Regulatory Cross-Talk between microRNAs and Novel Members of the B7 Family in Human Diseases: A Scoping Review., PMID:33800752
Characterization of BAY 1905254, an Immune Checkpoint Inhibitor Targeting the Immunoglobulin-Like Domain Containing Receptor 2 (ILDR2)., PMID:32312711
ILDR2 has a negligible role in hepatic steatosis., PMID:29847571
Tricellular tight junction-associated angulins in the gill epithelium of rainbow trout., PMID:29631364
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses., PMID:29431694
ILDR2-Fc Is a Novel Regulator of Immune Homeostasis and Inducer of Antigen-Specific Immune Tolerance., PMID:29431690
Angulin proteins ILDR1 and ILDR2 regulate alternative pre-mRNA splicing through binding to splicing factors TRA2A, TRA2B, or SRSF1., PMID:28785060
Genome-wide identification of genes essential for podocyte cytoskeletons based on single-cell RNA sequencing., PMID:28709640
ZNF70, a novel ILDR2-interacting protein, contributes to the regulation of HES1 gene expression., PMID:27353377
Tricellular Tight Junctions in the Inner Ear., PMID:27195292
Methyl-Arginine Profile of Brain from Aged PINK1-KO+A53T-SNCA Mice Suggests Altered Mitochondrial Biogenesis., PMID:27034888
[Molecular organization of tricellular tight junctions]., PMID:24790043
Localization of angulin-1/LSR and tricellulin at tricellular contacts of brain and retinal endothelial cells in vivo., PMID:24212375
ILDR2: an endoplasmic reticulum resident molecule mediating hepatic lipid homeostasis., PMID:23826244
Analysis of the 'angulin' proteins LSR, ILDR1 and ILDR2--tricellulin recruitment, epithelial barrier function and implication in deafness pathogenesis., PMID:23239027
For research use only. Not for human or drug use.
