Catalog No.
AHG84901
Biological activity
Measured by its ability to bind recombinant human IL-11 in a functional ELISA with an estimated Kd <1 nM.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser24-Val363
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14626
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IL-11RA, sIL-11R, Interleukin-11 receptor subunit alpha, sIL-11RA, IL11RA, IL-11R-alpha, IL-11R subunit alpha, IL-11 receptor subunit alpha, sIL11RA
Note
For research use only.
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis., PMID:31078624
Ubiquitin-Specific Protease 8 Mutant Corticotrope Adenomas Present Unique Secretory and Molecular Features and Shed Light on the Role of Ubiquitylation on ACTH Processing., PMID:31280266
Interleukin-11 Overexpression and M2 Macrophage Density are Associated with Angiogenic Activity in Proliferative Diabetic Retinopathy., PMID:31403827
Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications., PMID:31794912
IL-11 in cardiac and renal fibrosis: Late to the party but a central player., PMID:32022251
Multiple craniosynostosis and facial dysmorphisms with homozygous IL11RA variant caused by maternal uniparental isodisomy of chromosome 9., PMID:32277509
miR-19 regulates the expression of interferon-induced genes and MHC class I genes in human cancer cells., PMID:32308549
Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy., PMID:32530750
Prognostication of a 13-immune-related-gene signature in patients with early triple-negative breast cancer., PMID:32812178
Hepatocyte-specific IL11 cis-signaling drives lipotoxicity and underlies the transition from NAFLD to NASH., PMID:33397952
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload., PMID:33462828
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts., PMID:33590875
Host IL11 Signaling Suppresses CD4+ T cell-Mediated Antitumor Responses to Colon Cancer in Mice., PMID:33906864
The cytokine interleukin-11 crucially links bone formation, remodeling and resorption., PMID:33940443
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253
Similarities and differences between IL11 and IL11RA1 knockout mice for lung fibro-inflammation, fertility and craniosynostosis., PMID:34239012
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling., PMID:34435951
Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis., PMID:34447675
Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts., PMID:34570432
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts., PMID:34651016
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model., PMID:34667238
In Silico Identification and Clinical Validation of a Novel Long Non-Coding RNA/mRNA/miRNA Molecular Network for Potential Biomarkers for Discriminating SARS CoV-2 Infection Severity., PMID:34831321
Xenopus laevis il11ra.L is an experimentally proven interleukin-11 receptor component that is required for tadpole tail regeneration., PMID:35115663
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328
The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis., PMID:35331937
Interleukin-11 drives human and mouse alcohol-related liver disease., PMID:35365572
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis., PMID:35408908
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury., PMID:35806094
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues., PMID:36012165
Identification of recurrent variants implicated in disease in bicuspid aortic valve patients through whole-exome sequencing., PMID:36071494
MEK/ERK/RUNX2 Pathway-Mediated IL-11 Autocrine Promotes the Activation of Müller Glial Cells during Diabetic Retinopathy., PMID:36154781
FLUOROFENIDONE ATTENUATES PULMONARY INFLAMMATION AND FIBROSIS BY INHIBITING THE IL-11/MEK/ERK SIGNALING PATHWAY., PMID:36166195
CEP192 is a novel prognostic marker and correlates with the immune microenvironment in hepatocellular carcinoma., PMID:36238304
IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis., PMID:36376885
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease., PMID:36470928
[Interferon-related gene array in predicting the efficacy of interferon therapy in chronic hepatitis B]., PMID:36854551
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234
Gene Expression Changes in Cytokine and Chemokine Receptors in Association with Melanoma Liver Metastasis., PMID:37240247
The effect of hepatic stellate cell derived-IL-11 on hepatocyte injury in hepatic fibrosis., PMID:37495078
Targeting carcinoma-associated mesothelial cells with antibody-drug conjugates in ovarian carcinomatosis., PMID:37555348
Molecular characterization of the craniosynostosis-associated interleukin-11 receptor variants p.T306_S308dup and p.E364_V368del., PMID:37994264
Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway., PMID:38429845
Inhibiting IL11RA to mitigate hepatic metastasis in skin cutaneous melanoma: Comprehensive insights from in vitro and in vivo investigations., PMID:38468436
Enhancing antitumor immunity and achieving tumor eradication with IL11RA mRNA immunotherapy., PMID:38718659
Genetic regulation of injury-induced heterotopic ossification in adult zebrafish., PMID:38736327
Exploring the relationship between the interleukin family and lung adenocarcinoma through Mendelian randomization and RNA sequencing analysis., PMID:39264458
Interleukin 11 therapy causes acute left ventricular dysfunction., PMID:39383190
The structure of the IL-11 signalling complex provides insight into receptor variants associated with craniosynostosis., PMID:39462650
Urinary proteomics identifies distinct immunological profiles of sepsis associated AKI sub-phenotypes., PMID:39695715
Genetic Insights Into Craniosynostosis: Identification of Novel IL11RA Variants in Chinese Pediatric Patients., PMID:40353334
For research use only. Not for human or drug use.
