Catalog No.
AHG70401
Biological activity
Measured by its binding ability in a functional ELISA. When recombinant human Glucosylceramidase/GBA is immobilized at 2 µg/mL (100 µL/well), recombinant human SCARB2/CD36L2 (Cat #: AHG70401) binds with an ED50 of 100-800 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Arg27-Thr432
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q14108
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD36, 85 kDa lysosomal membrane sialoglycoprotein, CD36 antigen-like 2, CD36L2, SCARB2, Lysosome membrane protein 2, LIMP II, Scavenger receptor class B member 2, Lysosome membrane protein II, LIMPII, LIMP2, LGP85
Plasminogen deficiency reduces disease severity and immune responses in enterovirus A71-infected mice., PMID:40377310
Cryo-TEM structure of β-glucocerebrosidase in complex with its transporter LIMP-2., PMID:40159502
A New Human SCARB2 Knock-In Mouse Model for Studying Coxsackievirus A16 and Its Neurotoxicity., PMID:40143350
Integrative proteomic and lipidomic analysis of GNB1 and SCARB2 knockdown in human subcutaneous adipocytes., PMID:40127054
In vivo quantitative proteomic analysis of porcine alveolar macrophages in PRRSV-infected pigs., PMID:40096891
The Role of Disulfide Bridges in the Interaction of E. coli -Derived Recombinant SCARB2 and EV-A71's Capsid., PMID:40094096
Microscale Proteomic Analysis of the Endolymphatic Sac in Menière's Disease Patients., PMID:40062362
Establishment of a Panel of Human Cell Lines to Identify Cellular Receptors Used by Enteroviruses to Infect Cells., PMID:39940693
Cerebrospinal Fluid (CSF) Proteomic Signature in Preclinical and Clinical Alzheimer's disease (AD): Role of Adhesion Molecules., PMID:39877089
Metformin inhibits EV-A71 and CVA16 infections by regulating TRIB3-SCARB2 axis and activating AMPK., PMID:39826812
Prioritizing Parkinson's disease risk genes in genome-wide association loci., PMID:39711693
Novel virulence determinants in VP1 regulate the assembly of enterovirus-A71., PMID:39535185
Miglustat as Disease-Modifying Therapy in a Patient with SCARB2-Related Action Myoclonus Renal Failure., PMID:39512127
Adipocyte-derived glutathione promotes obesity-related breast cancer by regulating the SCARB2-ARF1-mTORC1 complex., PMID:39442522
Broadly therapeutic antibody provides cross-serotype protection against enteroviruses via Fc effector functions and by mimicking SCARB2., PMID:39424982
The lysosomal lipid transporter LIMP-2 is part of lysosome-ER STARD3-VAPB-dependent contact sites., PMID:39370902
Muscle growth differences in Lijiang pigs revealed by ATAC-seq multi-omics., PMID:39253524
Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy., PMID:39048581
Deficiency of Glucocerebrosidase Activity beyond Gaucher Disease: PSAP and LIMP-2 Dysfunctions., PMID:38928321
SCARB2 associates with tumor-infiltrating neutrophils and predicts poor prognosis in breast cancer., PMID:38914918
Unraveling Phenotypic Variability in Action Myoclonus with Renal Failure with SCARB2 Mutation in Siblings., PMID:38741477
Activation and Purification of ß-Glucocerebrosidase by Exploiting its Transporter LIMP-2 - Implications for Novel Treatment Strategies in Gaucher's and Parkinson's Disease., PMID:38666485
Gut dysbiosis impairs intestinal renewal and lipid absorption in Scarb2 deficiency-associated neurodegeneration., PMID:38635907
Enterovirus 71 Activates Plasmacytoid Dendritic Cell-Dependent PSGL-1 Binding Independent of Productive Infection., PMID:38629901
Simultaneous activation and blockade of autophagy to fight hepatocellular carcinoma., PMID:40395533
Enterovirus A71 does not meet the uncoating receptor SCARB2 at the cell surface., PMID:38359079
Long Non-Coding RNAs (lncRNAs) in Heart Failure: A Comprehensive Review., PMID:38250803
Tribbles pseudokinase 3 promotes enterovirus A71 infection via dual mechanisms., PMID:38240287
Sophora tonkinensis and active compounds inhibit mitochondrial impairments, inflammation, and LDLR deficiency in myocardial ischemia mice through regulating the vesicle-mediated transport pathway., PMID:38007052
Identification of Potentially Novel Molecular Targets of Endometrial Cancer Using a Non-Biased Proteomic Approach., PMID:37760635
SCARB2 drives hepatocellular carcinoma tumor initiating cells via enhanced MYC transcriptional activity., PMID:37739936
Action Myoclonus-Renal Failure Syndrome: A Case Report with Bioinformatic Annotations., PMID:37529812
Antibody signatures in hospitalized hand, foot and mouth disease patients with acute enterovirus A71 infection., PMID:37262073
Functional screening of lysosomal storage disorder genes identifies modifiers of alpha-synuclein neurotoxicity., PMID:37200393
Association of muscular strength and targeted proteomics involved in brain health in children with overweight/obesity., PMID:37190796
Human SCARB2 Acts as a Cellular Associator for Helping Coxsackieviruses A10 Infection., PMID:37112912
The effects of SCARB2 and SELPLG gene polymorphisms on EV71 infection in hand, foot and mouth disease., PMID:37078358
Inhibitory effects and mechanisms of proanthocyanidins against enterovirus 71 infection., PMID:36944412
Investigation of 2-Hydroxypropyl-β-Cyclodextrin Treatment in a Neuronal-Like Cell Model of Niemann-Pick Type C Using Quantitative Proteomics., PMID:36920149
Lysosome-targeted multifunctional lipid probes reveal the sterol transporter NPC1 as a sphingosine interactor., PMID:36893262
Dual blockages of a broad and potent neutralizing IgM antibody targeting GH loop of EV-As., PMID:36726218
Discovery and replication of blood-based proteomic signature of PTSD in 9/11 responders., PMID:36631443
Molecular mechanism of antibody neutralization of coxsackievirus A16., PMID:36543790
Zhachong Shisanwei Pill resists ischemic stroke by lysosome pathway based on proteomics and bioinformatics., PMID:36183948
Whole genome sequencing identifies candidate genes for familial essential tremor and reveals biological pathways implicated in essential tremor aetiology., PMID:36183486
LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol., PMID:35987341
The Deficiency of SCARB2/LIMP-2 Impairs Metabolism via Disrupted mTORC1-Dependent Mitochondrial OXPHOS., PMID:35955761
The uncoating of EV71 in mature late endosomes requires CD-M6PR., PMID:35929543
Mouse Scarb2 Modulates EV-A71 Pathogenicity in Neonatal Mice., PMID:35867561
For research use only. Not for human or drug use.
