Catalog No.
AHG12801
Biological activity
Measured by its ability to induce ERK1/ERK2 phosphorylation in human acute T cell leukemia cells (Jurkat). 5-15 μg/mL of recombinant human TFF3 (Cat #: AHG12801) can effectively induce ERK1/2 phosphorylation.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Glu22-Phe80
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q07654
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Polypeptide P1.B, Trefoil factor 3, TFF3, hITF, ITF, Intestinal trefoil factor, TFI, hP1.B
Note
For research use only.
Dietary supplementation with dihydroartemisinin improves intestinal barrier function in weaned piglets with intrauterine growth retardation by modulating the gut microbiota., PMID:38813622
Acute hyperbilirubinemia determines an early subclinical renal damage: Evaluation of tubular biomarkers in cholemic nephropathy., PMID:38837303
Trefoil Factor 2 Expressed by the Murine Pancreatic Acinar Cells Is Required for the Development of Islets and for β-Cell Function During Aging., PMID:38905124
Microbiome and metabolome analyses reveal significant alterations of gut microbiota and bile acid metabolism in ETEC-challenged weaned piglets by dietary berberine supplementation., PMID:38983627
Association of serum trefoil factor 3 and leptin levels with obesity: A case-control study., PMID:38996578
Prediction of the Aggressive Clinical Course of Papillary Thyroid Carcinoma Based on Fine Needle Aspiration Biopsy Molecular Testing., PMID:39000197
The Aberrant Expression of Biomarkers and Risk Prediction for Neoplastic Changes in Barrett's Esophagus-Dysplasia., PMID:39001449
The Effect of High-Salt Diet on Oxidative Stress Production and Vascular Function in Tff3-/-/C57BL/6N Knockout and Wild Type (C57BL/6N) Mice., PMID:39074455
Improving histotyping precision: The impact of immunohistochemical algorithms on epithelial ovarian cancer classification., PMID:39084566
Letter: Answer to "Trefoil Factor-3 and Peripheral Artery Disease: Reason or Result"., PMID:39187412
Marine Algae and Deriving Biomolecules for the Management of Inflammatory Bowel Diseases: Potential Clinical Therapeutics to Decrease Gut Inflammatory and Oxidative Stress Markers?, PMID:39195452
The diagnostic value of serum trefoil factor 3 and pepsinogen combination in chronic atrophic gastritis: a retrospective study based on a gastric cancer screening cohort in the community population., PMID:39234749
Spatial resolved transcriptomics reveals distinct cross-talk between cancer cells and tumor-associated macrophages in intrahepatic cholangiocarcinoma., PMID:39256888
Circulating Plasma Proteins in Aortic Stenosis: Associations With Severity, Myocardial Response, and Clinical Outcomes., PMID:39344657
TFF3 and PVRL2 co-targeting identified by multi-omics approach as an effective cancer immunosuppression strategy., PMID:39369842
Cost-effective identification of Barrett's esophagus in the community: A first step towards screening., PMID:39385742
Goblet cell differentiation subgroups in colorectal cancer., PMID:39401352
Trefoil Factor 3 in human serum as a predictor of disease activity in Egyptian ulcerative colitis patients and its role in colorectal cancer., PMID:39404647
Protective Effect of IgY Embedded in W/O/W Emulsion on LPS Enteritis-Induced Colonic Injury in Mice., PMID:39408328
Cardiovascular Disease May Be Triggered by Gut Microbiota, Microbial Metabolites, Gut Wall Reactions, and Inflammation., PMID:39408963
Plasma Proteomic Biomarkers in Alzheimer's Disease and Cardiovascular Disease: A Longitudinal Study., PMID:39409080
Role of Emerging Urinary Biomarkers in Predicting Progressive Deterioration of Kidney Function in Congenital Anomalies of Kidney and Urinary Tract: Trefoil Family Factor 3, Alpha Soluble Klotho and Urinary Microalbuminuria., PMID:39477750
Proximity Elongation Assay and ELISA for the Identification of Serum Diagnostic Biomarkers in Parkinson's Disease and Progressive Supranuclear Palsy., PMID:39519214
Trefoil Factor Protein 3 (TFF3) as a Guardian of the Urinary Bladder Epithelium., PMID:39579021
Protective effect of Dulaglutide, a GLP1 agonist, on acetic acid-induced ulcerative colitis in rats: involvement of GLP-1, TFF-3, and TGF-β/PI3K/NF-κB signaling pathway., PMID:39579211
[Huangqin Decoction alleviates ulcerative colitis in mice by reducing endoplasmic reticulum stress]., PMID:39623273
A bioadhesive antioxidase-overexpressed probiotic prevents radiation enteritis by scavenging the excess reactive oxygen species., PMID:39643134
The effect of haemoglobin and blood transfusion on preterm infant gut perfusion and injury., PMID:39649403
TFF3 drives Hippo dependent EGFR-TKI resistance in lung adenocarcinoma., PMID:39658649
[Metabolic Profile of Gut Microbiota and Levels of Trefoil Factors in Adults with Different Metabolic Phenotypes of Obesity]., PMID:39709568
Causal associations between circulating protein ratios and drug resistance in papillary thyroid cancer: a Mendelian randomization study., PMID:39754686
Soluble Immune Checkpoint Protein and Lipid Network Associations with All-Cause Mortality Risk: Trans-Omics for Precision Medicine (TOPMed) Program., PMID:39830278
Machine learning-based identification of proteomic markers in colorectal cancer using UK Biobank data., PMID:39839775
Roux-en-Y gastric bypass improves liver and glucose homeostasis in Zucker diabetic fatty rats by upregulating hepatic trefoil factor family 3 and activating the phosphatidylinositol 3-kinase/protein kinase B pathway., PMID:39893149
Urine biomarkers, acute kidney injury, and fluid overload in neonatal cardiac surgery., PMID:39910862
Gingivitis and periodontitis among Indian patients diagnosed using trefoil factor 3., PMID:39917209
Inhibition of TFF3 synergizes with c-MET inhibitors to decrease the CSC-like phenotype and metastatic burden in ER+HER2+ mammary carcinoma., PMID:39920140
The structural integrity of human TFF1 under reducing conditions., PMID:39978303
TFF3 facilitates dormancy of anti-estrogen treated ER+ mammary carcinoma., PMID:39984660
Nephrotoxicity biomarkers following propanil (3,4-dichloropropionanilide) self-poisoning., PMID:40034038
Circulating Inflammation Biomarkers and the Risk of Esophageal Adenocarcinoma: A Nested Case-Control Study in the Department of Defense Serum Repository., PMID:40079721
The Diagnostic Role of TFF1, TFF3, FOXA1, CA XII and TRPS1 in Serous Effusions., PMID:40170411
Targeting Trefoil Factor Family 3 in Obstructive Airway Diseases: A Computational Approach to Novel Therapeutics., PMID:40224201
Exploring the Structure-Activity Relationship of F. velutipes Polysaccharide: A Novel Promising Anti-Inflammatory and Intestinal Barrier-Protective Molecule Extracted by Ultrasound., PMID:40249037
Lactobacillus paracasei Expressing Porcine Trefoil Factor 3 and Epidermal Growth Factor: A Novel Approach for Superior Mucosal Repair., PMID:40284867
Thymol promotes cell proliferation and protects against LPS-induced intestinal inflammation via activation of the EGFR/PI3K pathway., PMID:40351714
Spatial Study of TLR4, TLR5 and TLR9 in Gastric Premalignant Lesions Before and After Helicobacter pylori Eradication., PMID:40362298
The Effect of Tff3 Deficiency on the Liver of Mice Exposed to a High-Fat Diet., PMID:40426854
TFF3 as a Potential Prognostic Biomarker in Myelodysplastic Syndrome and Acute Myeloid Leukaemia., PMID:40491107
TFF3 Gene as a Molecular Target Potentially Shared by Idiopathic Pulmonary Fibrosis and Pulmonary Hypertension: Drug Repurposing Prospect with Aminoglutethimide., PMID:40491360
For research use only. Not for human or drug use.
