Catalog No.
ARA15301
Biological activity
Measured by its binding ability in a functional ELISA. When rrNotch-1 is coated at 5 μg/mL, rrDLL1 (Cat #: ARA15301) binds with an apparent Kd <5 nM.
Expression system
Mammalian Cells
Species
Rattus norvegicus (Rat)
Protein length
Ser22-Ser534
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P97677
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Delta-like protein 1, Drosophila Delta homolog 1, Delta1, H-Delta-1, DLL1, UNQ146/PRO172
The critical role of Id2 gene in mesenchymal stem cell therapy for colitis through regulating immune response and microbiota., PMID:40450917
NOTCH1-STAT3 signaling axis regulates astrocytic differentiation of hippocampal neural stem/progenitor cells., PMID:40273624
Human Myobundle Platform for Studying the Role of Notch Signaling in Satellite Cell Phenotype and Function., PMID:40123310
Bordetella adenylate cyclase toxin elicits chromatin remodeling and transcriptional reprogramming that blocks differentiation of monocytes into macrophages., PMID:40105369
Host-derived Delta-like Canonical Notch ligand-1 in sepsis and septic shock: Infection site, pathogens and disease severity matter - Secondary analysis of data from a randomized controlled trial., PMID:40043814
Identification and Validation of Biomarkers for Alzheimer's Disease Based on Akt and Wnt Signaling Pathways in Mouse Models., PMID:39992588
Notch signaling pathway in osteogenesis, bone development, metabolism, and diseases., PMID:39985304
Usp11 maintained the survival of marginal zone B cells under ionizing radiation by deubiquitinating DLL1 and JAG2., PMID:39904982
Cellular signalling protrusions enable dynamic distant contacts in spinal cord neurogenesis., PMID:39835478
Diversity in Notch ligand-receptor signaling interactions., PMID:39751380
Role of the Notch signaling pathway in porcine oocyte maturation., PMID:39748238
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs., PMID:39731910
Mll4 in skeletal muscle fibers maintains muscle stem cells., PMID:39710699
Differential Effects of Four Canonical Notch-Activating Ligands on c-Kit+ Cardiac Progenitor Cells., PMID:39456964
Brain ischemia causes systemic Notch1 activity in endothelial cells to drive atherosclerosis., PMID:39079536
CD133 expression is associated with less DNA repair, better response to chemotherapy and survival in ER-positive/HER2-negative breast cancer., PMID:39017815
Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development., PMID:38976017
Another Notch in the Belt of Rheumatoid Arthritis., PMID:38961731
Characterization of expression patterns and dynamic relocation of Notch proteins during acrosome reaction of bull spermatozoa., PMID:38942812
[The Role of Notch Signaling Pathway in Adult Patients with Epstein-Barr Virus-induced Infectious Mononucleosis]., PMID:38926989
Low-intensity pulsed ultrasound combined with ST36 modulate gastric smooth muscle contractile marker expression via RhoA/Rock and MALAT1/miR-449a/DLL1 signaling in diabetic rats., PMID:38873849
Effect of humanine on the Notch signaling pathway in myocardial infarction., PMID:38813496
DLL1/NOTCH1 signaling pathway maintain angiogenesis in meniscus development and degeneration., PMID:38772475
Unveiling the potential of estrogen: Exploring its role in neuropsychiatric disorders and exercise intervention., PMID:38704108
Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O -fucose modification on EGF12 in human development., PMID:38645096
Jagged2 targeting in lung cancer activates anti-tumor immunity via Notch-induced functional reprogramming of tumor-associated macrophages., PMID:38636522
Novel small molecule DMAMCL induces differentiation in rhabdomyosarcoma by downregulating of DLL1., PMID:38626518
Canonical notch activation in patients with scrub typhus: association with organ dysfunction and poor outcome., PMID:38502427
LINC00460 promotes neuroblastoma tumorigenesis and cisplatin resistance by targeting miR-149-5p/DLL1 axis and activating Notch pathway in vitro and in vivo., PMID:38161194
Epigenetically dysregulated NOTCH-Delta-HES signaling cascade can serve as a subtype classifier for acute lymphoblastic leukemia., PMID:37922005
Fish Collagen Peptides Enhance Thymopoietic Gene Expression, Cell Proliferation, Thymocyte Adherence, and Cytoprotection in Thymic Epithelial Cells via Activation of the Nuclear Factor-κB Pathway, Leading to Thymus Regeneration after Cyclophosphamide-Induced Injury., PMID:37888466
Effects of an Adipose Mesenchymal Stem Cell-Derived Conditioned medium and TGF-β1 on Human Keratinocytes In Vitro., PMID:37834173
Kindlin-2 in myoepithelium controls luminal progenitor commitment to alveoli in mouse mammary gland., PMID:37833248
Single-cell RNA sequencing of human epidermis identifies Lunatic fringe as a novel regulator of the stem cell compartment., PMID:37832539
NOTCH Pathway Genes in Ovarian Cancer: Clinical Significance and Associations with Immune Cell Infiltration., PMID:37796700
Notch ligands are biomarkers of anti-TNF response in RA patients., PMID:37796367
CSF-1 and Notch signaling cooperate in macrophage instruction and tissue repair during peripheral limb ischemia., PMID:37691936
SDF-1 and NOTCH signaling in myogenic cell differentiation: the role of miRNA10a, 425, and 5100., PMID:37582765
A new fasciocutaneous flap model identifies a critical role for endothelial Notch signaling in wound healing and flap survival., PMID:37532879
An investigation into the role of Notch signaling, altered angiogenesis, and inflammatory-induced preterm delivery and related complications in Northeast Indian patients., PMID:37421871
Hidradenitis suppurativa presents a methylome dysregulation capable to explain the pro-inflammatory microenvironment: Are these DNA methylations potential therapeutic targets?, PMID:37338327
Two NOTCH1 O-fucose sites have opposing functions in mouse retinal angiogenesis., PMID:37329502
Evaluation of the Novel Sepsis Biomarker Host-Derived Delta-like Canonical Notch Ligand 1-A Secondary Analysis of 405 Patients Suffering from Inflammatory or Infectious Diseases., PMID:37298115
Bioprinted Notch ligand to function as stem cell niche improves muscle regeneration in dystrophic muscle., PMID:37292170
MicroRNA-143 acts as a tumor suppressor through Musashi-2/DLL1/Notch1 and Musashi-2/Snail1/MMPs axes in acute myeloid leukemia., PMID:37149661
F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway., PMID:37082613
DEX-Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T-Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy., PMID:37072664
The potential value of Notch1 and DLL1 in the diagnosis and prognosis of patients with active TB., PMID:37063841
Tibetan medicine Qi-Sai-Er-Sang-Dang-Song Decoction inhibits TNF-α-induced rheumatoid arthritis in human fibroblast-like synoviocytes via regulating NOTCH1/NF-κB/NLRP3 pathway., PMID:36966850
The phenotypic spectrum of terminal 6q deletions based on a large cohort derived from social media and literature: a prominent role for DLL1., PMID:36935482
For research use only. Not for human or drug use.
