Please ensure Javascript is enabled for purposes of website accessibility
Home / Products / Recombinant Protein / Functional Protein

Recombinant Human NPTX2 Protein, C-His (Active)

Catalog #:   AHE53801 Specific References (50) DATASHEET
Applications: Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Expression system: Mammalian Cells
Accession: P47972
Protein length: Gly16-Leu431
Overview

Catalog No.

AHE53801

Biological activity

Measured by the ability of the immobilized protein to support the adhesion of human medullary thyroid cancer cells (TT). The ED50 for this effect is 0.6‑2.4 μg/mL.

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Gly16-Leu431

Nature

Recombinant

Endotoxin level

<0.1 EU/μg of the protein by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Accession

P47972

Applications

Bioactivity, ELISA, Immunogen, SDS-PAGE, WB

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

NP-II, NP2, Neuronal pentraxin-2, Neuronal pentraxin II, NPTX2

Data Image
  • SDS-PAGE
    SDS-PAGE for Recombinant Human NPTX2 protein
References

Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort., PMID:40461705

Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'., PMID:40329321

A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease., PMID:40164724

Associations between cerebrospinal fluid synaptic protein biomarkers and cognitive function in bipolar disorder., PMID:40081262

NPTX2 transfection improves synaptic E/I balance and performance in learning impaired aged rats., PMID:40057261

Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342

Exploring the Relationship Between Serum Neuronal Pentraxin 2 and Poststroke Cognitive Impairment in Patients With First-Episode Acute Ischemic Stroke., PMID:39924979

Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma., PMID:39917460

Chemoproteomics Sheds Light on Epigenetic Targets of [11C]Martinostat in the Human Brain., PMID:39912892

Biomarker treatment effects in two phase 3 trials of gantenerumab., PMID:39887500

Mapping the Cerebrospinal Fluid Proteome in Bipolar Disorder., PMID:39827936

Xixin Decoction May Treat Vascular Dementia by Modulating the NPTX2/C1q/C3 Complement Pathway., PMID:39737553

Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease., PMID:39573823

Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice., PMID:39486775

miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease., PMID:39289904

Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer's Disease., PMID:39121126

Expression of activity-regulated transcripts in pyramidal neurons across the cortical visuospatial working memory network in unaffected comparison individuals and individuals with schizophrenia., PMID:39033685

Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer's disease and a history of traumatic brain injury., PMID:38908030

Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study., PMID:38723679

Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation., PMID:38597235

Breakthroughs in Alzheimer's Research: A Path to a More Promising Future?, PMID:38584978

Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis., PMID:38566855

Neuronal pentraxin 2 correlates with neurodegeneration but not cognition in idiopathic normal pressure hydrocephalus (iNPH)., PMID:38393959

A model of human neural networks reveals NPTX2 pathology in ALS and FTLD., PMID:38355792

The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease., PMID:38355535

Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases., PMID:38325331

Aberrant DNA Methylation of NPTX2 as an Indicator of Malignant Behavior in Thymic Epithelial Tumors., PMID:38254821

Emerging perspectives of synaptic biomarkers in ALS and FTD., PMID:38249293

Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia., PMID:38191677

Cerebrospinal fluid NPTX2 changes and relationship with regional brain metabolism metrics across mild cognitive impairment due to Alzheimer's disease., PMID:38157030

Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation., PMID:38109308

The pentraxin family in autoimmune disease., PMID:37832905

Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression., PMID:37763230

An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model., PMID:37719746

Assessments of the Utilities of CSF NPTX2 for Disease Progression in Cognitively Normal Individuals Who Progress to Clinical MCI and AD., PMID:37614206

Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease., PMID:37468915

NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment., PMID:37345460

Discovery of Biomarkers for Amyotrophic Lateral Sclerosis from Human Cerebrospinal Fluid Using Mass-Spectrometry-Based Proteomics., PMID:37238921

Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease., PMID:37160957

Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress., PMID:37100209

Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation., PMID:37019088

The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration., PMID:36989373

Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer's disease and frontotemporal dementia., PMID:36964594

H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways., PMID:36703136

NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL., PMID:36638907

Cerebrospinal Fluid Biomarkers of Synaptic Dysfunction are Altered in Parkinson's Disease and Related Disorders., PMID:36504237

The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland., PMID:36470533

CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework., PMID:36368195

A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias., PMID:36120776

Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia., PMID:36045450

Datasheet
$ 360
Product specifications
50 μg 360 100 μg 580

Contact Information

Order: order@antibodysystem.com

Mail: support@antibodysystem.com

Distributor list

For research use only. Not for human or drug use.

Need help with your order?

Find out more about placing an order here

Recombinant Human NPTX2 Protein, C-His (Active) [AHE53801]
Terms of sale Website terms of use Cookie policy Privacy
Copyright © 2025 AntibodySystem SAS. All Rights Reserved.            All Products are for Research Use Only