Catalog No.
AHE53801
Biological activity
Measured by the ability of the immobilized protein to support the adhesion of human medullary thyroid cancer cells (TT). The ED50 for this effect is 0.6‑2.4 μg/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gly16-Leu431
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P47972
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NP-II, NP2, Neuronal pentraxin-2, Neuronal pentraxin II, NPTX2
Synaptic markers are associated with cognitive decline after accounting for amyloid burden among an at-risk Alzheimer's disease cohort., PMID:40461705
Cerebrospinal fluid proteome profiling across the Alzheimer's disease continuum: a step towards solving the equation for 'X'., PMID:40329321
A cerebrospinal fluid synaptic protein biomarker for prediction of cognitive resilience versus decline in Alzheimer's disease., PMID:40164724
Associations between cerebrospinal fluid synaptic protein biomarkers and cognitive function in bipolar disorder., PMID:40081262
NPTX2 transfection improves synaptic E/I balance and performance in learning impaired aged rats., PMID:40057261
Biological signatures in the Alzheimer's continuum discriminate between diagnosis-related and -unrelated associations to ATN categories., PMID:40046342
Exploring the Relationship Between Serum Neuronal Pentraxin 2 and Poststroke Cognitive Impairment in Patients With First-Episode Acute Ischemic Stroke., PMID:39924979
Serum Oxidative Stress-related Biomarkers in Ocular Hypertension and Glaucoma., PMID:39917460
Chemoproteomics Sheds Light on Epigenetic Targets of [11C]Martinostat in the Human Brain., PMID:39912892
Biomarker treatment effects in two phase 3 trials of gantenerumab., PMID:39887500
Mapping the Cerebrospinal Fluid Proteome in Bipolar Disorder., PMID:39827936
Xixin Decoction May Treat Vascular Dementia by Modulating the NPTX2/C1q/C3 Complement Pathway., PMID:39737553
Hypometabolic mismatch with atrophy and tau pathology in mixed Alzheimer's and Lewy body disease., PMID:39573823
Neonatal hypoxia-ischemia alters the events governing the hippocampal critical period of postnatal synaptic plasticity leading to deficits in working memory in mice., PMID:39486775
miR-133b as a potential regulator of a synaptic NPTX2 protein in Alzheimer's disease., PMID:39289904
Serial Cerebrospinal Fluid Sampling Reveals Trajectories of Potential Synaptic Biomarkers in Early Stages of Alzheimer's Disease., PMID:39121126
Expression of activity-regulated transcripts in pyramidal neurons across the cortical visuospatial working memory network in unaffected comparison individuals and individuals with schizophrenia., PMID:39033685
Cerebrospinal fluid biomarkers and cognitive trajectories in patients with Alzheimer's disease and a history of traumatic brain injury., PMID:38908030
Cerebrospinal fluid synaptic biomarker changes in bipolar disorder - A longitudinal case-control study., PMID:38723679
Inhibition of neuronal pentraxin 2 relieved epileptic seizure via reducing GluA1 phosphorylation., PMID:38597235
Breakthroughs in Alzheimer's Research: A Path to a More Promising Future?, PMID:38584978
Serum NFL and tau, but not serum UCHL-1 and GFAP or CSF SNAP-25, NPTX2, or sTREM2, correlate with delirium in a 3-year retrospective analysis., PMID:38566855
Neuronal pentraxin 2 correlates with neurodegeneration but not cognition in idiopathic normal pressure hydrocephalus (iNPH)., PMID:38393959
A model of human neural networks reveals NPTX2 pathology in ALS and FTLD., PMID:38355792
The use of synaptic biomarkers in cerebrospinal fluid to differentiate behavioral variant of frontotemporal dementia from primary psychiatric disorders and Alzheimer's disease., PMID:38355535
Cerebrospinal fluid biomarker panel for synaptic dysfunction in a broad spectrum of neurodegenerative diseases., PMID:38325331
Aberrant DNA Methylation of NPTX2 as an Indicator of Malignant Behavior in Thymic Epithelial Tumors., PMID:38254821
Emerging perspectives of synaptic biomarkers in ALS and FTD., PMID:38249293
Levels of neuronal pentraxin 2 in plasma is associated with cognitive function in patients with schizophrenia., PMID:38191677
Cerebrospinal fluid NPTX2 changes and relationship with regional brain metabolism metrics across mild cognitive impairment due to Alzheimer's disease., PMID:38157030
Single-cell transcriptomic analysis reveals rich pituitary-Immune interactions under systemic inflammation., PMID:38109308
The pentraxin family in autoimmune disease., PMID:37832905
Synergism of Carbamoylated Erythropoietin and Insulin-like Growth Factor-1 in Immediate Early Gene Expression., PMID:37763230
An interventional study of baicalin on neuronal pentraxin-1, neuronal pentraxin-2, and C-reactive protein in Alzheimer's disease rat model., PMID:37719746
Assessments of the Utilities of CSF NPTX2 for Disease Progression in Cognitively Normal Individuals Who Progress to Clinical MCI and AD., PMID:37614206
Quantitative proteomics of cerebrospinal fluid from African Americans and Caucasians reveals shared and divergent changes in Alzheimer's disease., PMID:37468915
NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment., PMID:37345460
Discovery of Biomarkers for Amyotrophic Lateral Sclerosis from Human Cerebrospinal Fluid Using Mass-Spectrometry-Based Proteomics., PMID:37238921
Quantitative Mass Spectrometry Analysis of Cerebrospinal Fluid Protein Biomarkers in Alzheimer's Disease., PMID:37160957
Decreased expression of synaptic genes in the vestibular ganglion of rodents following subchronic ototoxic stress., PMID:37100209
Sexual Dimorphism in the Closure of the Hippocampal Postnatal Critical Period of Synaptic Plasticity after Intrauterine Growth Restriction: Link to Oligodendrocyte and Glial Dysregulation., PMID:37019088
The neuronal pentraxin Nptx2 regulates complement activity and restrains microglia-mediated synapse loss in neurodegeneration., PMID:36989373
Synaptic biomarkers in the cerebrospinal fluid associate differentially with classical neuronal biomarkers in patients with Alzheimer's disease and frontotemporal dementia., PMID:36964594
H3K4me3 mediates uterine leiomyoma pathogenesis via neuronal processes, synapsis components, proliferation, and Wnt/β-catenin and TGF-β pathways., PMID:36703136
NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL., PMID:36638907
Cerebrospinal Fluid Biomarkers of Synaptic Dysfunction are Altered in Parkinson's Disease and Related Disorders., PMID:36504237
The First Pituitary Proteome Landscape From Matched Anterior and Posterior Lobes for a Better Understanding of the Pituitary Gland., PMID:36470533
CSF peptides from VGF and other markers enhance prediction of MCI to AD progression using the ATN framework., PMID:36368195
A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias., PMID:36120776
Differential impairment of cerebrospinal fluid synaptic biomarkers in the genetic forms of frontotemporal dementia., PMID:36045450