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Recombinant Human IL36B/IL-1F8 Protein, No tag (Active)

Catalog #:   AHJ69601 Specific References (43) DATASHEET
Applications: Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Expression system: E. coli
Accession: Q9NZH7
Protein length: Arg5-Asn157
Overview

Catalog No.

AHJ69601

Biological activity

Measured by its ability to induce IL-8 secretion in human epithelial carcinoma cells (A431). The ED50 for this effect is 1-4.8 ng/mL.

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Arg5-Asn157

Nature

Recombinant

Endotoxin level

<0.1 EU/μg of the protein by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Accession

Q9NZH7

Applications

Bioactivity, ELISA, Immunogen, SDS-PAGE, WB

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Interleukin-1 family member 8, Interleukin-1 homolog 2, IL36B, IL1H2, Interleukin-1 eta, FIL1 eta, IL-1H2, IL-1F8, Interleukin-36 beta, IL1F8, IL-1 eta

Data Image
References

Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030

The Critical Role of Pyroptosis in Peri-Implantitis., PMID:38495343

Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases., PMID:38189700

The elevation of plasma galectin-9 levels in patients with psoriasis and its associations with inflammatory and immune checkpoint molecules in skin tissues., PMID:38092632

Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis., PMID:37446281

Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands., PMID:36216205

IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic., PMID:35903102

IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease., PMID:35698471

Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response., PMID:35436743

Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes., PMID:34987646

Compartmentalization of interleukin 36 subfamily according to inducible and constitutive expression in the kidneys of a murine autoimmune nephritis model., PMID:34287716

MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment., PMID:33990899

IL-36 in chronic inflammation and fibrosis - bridging the gap?, PMID:33463541

Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract patients., PMID:33115414

Effect of Interleukin-36β on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis., PMID:32421784

IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?, PMID:32013927

Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases., PMID:31736959

IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners., PMID:31619669

IL-36β Promotes Inflammatory Activity and Inhibits Differentiation of Keratinocytes In Vitro., PMID:31601303

Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis., PMID:31504934

Upregulation of IL-36 cytokines in folliculitis and eosinophilic pustular folliculitis., PMID:31424098

Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon., PMID:31010609

1H, 13C, and 15N resonance assignments of the cytokine interleukin-36β isoform-2., PMID:30758717

miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4., PMID:30513512

Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature., PMID:29803800

RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature., PMID:29434599

Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop., PMID:28975626

Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis., PMID:28967976

IL-36 induces cytokine IL-6 and chemokine CXCL8 expression in human lung tissue cells: Implications for pulmonary inflammatory responses., PMID:28869889

Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa., PMID:28602023

Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats., PMID:28024685

Are neutrophilic dermatoses autoinflammatory disorders?, PMID:27905098

The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases., PMID:27783881

Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease., PMID:26701127

Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease., PMID:25247780

Biology of IL-36 cytokines and their role in disease., PMID:24355486

The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36γ., PMID:22318382

Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9., PMID:22144259

Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity., PMID:21965679

Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis., PMID:21881584

IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression., PMID:21242515

IL-1 family nomenclature., PMID:20959797

IL-1 gene cluster is not linked to aggressive periodontitis., PMID:20335539

Datasheet
$ 360
Product specifications
50 μg 360 100 μg 580

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For research use only. Not for human or drug use.

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Recombinant Human IL36B/IL-1F8 Protein, No tag (Active) [AHJ69601]
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