Catalog No.
AHJ69601
Biological activity
Measured by its ability to induce IL-8 secretion in human epithelial carcinoma cells (A431). The ED50 for this effect is 1-4.8 ng/mL.
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg5-Asn157
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9NZH7
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Interleukin-1 family member 8, Interleukin-1 homolog 2, IL36B, IL1H2, Interleukin-1 eta, FIL1 eta, IL-1H2, IL-1F8, Interleukin-36 beta, IL1F8, IL-1 eta
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
The Critical Role of Pyroptosis in Peri-Implantitis., PMID:38495343
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases., PMID:38189700
The elevation of plasma galectin-9 levels in patients with psoriasis and its associations with inflammatory and immune checkpoint molecules in skin tissues., PMID:38092632
Increased Interleukin-36β Expression Promotes Angiogenesis in Japanese Atopic Dermatitis., PMID:37446281
Pellino1 Restricts Herpes Simplex Virus Infections in the Epidermis and Dissemination to Sebaceous Glands., PMID:36216205
IL-36 Cytokines: Their Roles in Asthma and Potential as a Therapeutic., PMID:35903102
IL-36 is Closely Related to Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease., PMID:35698471
Interleukin-36β exacerbates DSS-induce acute colitis via inhibiting Foxp3+ regulatory T cell response and increasing Th2 cell response., PMID:35436743
Integrated analysis of circulating immune cellular and soluble mediators reveals specific COVID19 signatures at hospital admission with utility for prediction of clinical outcomes., PMID:34987646
Compartmentalization of interleukin 36 subfamily according to inducible and constitutive expression in the kidneys of a murine autoimmune nephritis model., PMID:34287716
MMP-3 plays a major role in calcium pantothenate-promoted wound healing after fractional ablative laser treatment., PMID:33990899
IL-36 in chronic inflammation and fibrosis - bridging the gap?, PMID:33463541
Angiogenin, FGF-α, and IL-36β have higher expression levels in aqueous humor of nAMD patients in comparison to cataract patients., PMID:33115414
Effect of Interleukin-36β on Activating Autophagy of CD4+CD25+ Regulatory T cells and Its Immune Regulation in Sepsis., PMID:32421784
IL-36 s in the colorectal cancer: is interleukin 36 good or bad for the development of colorectal cancer?, PMID:32013927
Biology of IL-36 Signaling and Its Role in Systemic Inflammatory Diseases., PMID:31736959
IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners., PMID:31619669
IL-36β Promotes Inflammatory Activity and Inhibits Differentiation of Keratinocytes In Vitro., PMID:31601303
Interleukin-36 family dysregulation drives joint inflammation and therapy response in psoriatic arthritis., PMID:31504934
Upregulation of IL-36 cytokines in folliculitis and eosinophilic pustular folliculitis., PMID:31424098
Cyto/chemokine profile of in vitro scratched keratinocyte model: Implications of significant upregulation of CCL20, CXCL8 and IL36G in Koebner phenomenon., PMID:31010609
1H, 13C, and 15N resonance assignments of the cytokine interleukin-36β isoform-2., PMID:30758717
miRNA-544a Regulates the Inflammation of Spinal Cord Injury by Inhibiting the Expression of NEUROD4., PMID:30513512
Ichthyosis molecular fingerprinting shows profound TH17 skewing and a unique barrier genomic signature., PMID:29803800
RNA-Seq Analysis of IL-1B and IL-36 Responses in Epidermal Keratinocytes Identifies a Shared MyD88-Dependent Gene Signature., PMID:29434599
Interleukin-36 in hidradenitis suppurativa: evidence for a distinctive proinflammatory role and a key factor in the development of an inflammatory loop., PMID:28975626
Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis., PMID:28967976
IL-36 induces cytokine IL-6 and chemokine CXCL8 expression in human lung tissue cells: Implications for pulmonary inflammatory responses., PMID:28869889
Increased expression of the interleukin-36 cytokines in lesions of hidradenitis suppurativa., PMID:28602023
Decreases in 15-lipoxygenase metabolites in Olmsted syndrome model rats., PMID:28024685
Are neutrophilic dermatoses autoinflammatory disorders?, PMID:27905098
The emergence of the IL-36 cytokine family as novel targets for inflammatory diseases., PMID:27783881
Distinct expression of interleukin (IL)-36α, β and γ, their antagonist IL-36Ra and IL-38 in psoriasis, rheumatoid arthritis and Crohn's disease., PMID:26701127
Gingival crevicular fluid interleukin-36β (-1F8), interleukin-36γ (-1F9) and interleukin-33 (-1F11) levels in different periodontal disease., PMID:25247780
Biology of IL-36 cytokines and their role in disease., PMID:24355486
The double-stranded RNA analogue polyinosinic-polycytidylic acid induces keratinocyte pyroptosis and release of IL-36γ., PMID:22318382
Expression of IL-1Rrp2 by human myelomonocytic cells is unique to DCs and facilitates DC maturation by IL-1F8 and IL-1F9., PMID:22144259
Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36α, IL-36β, and IL-36γ) or antagonist (IL-36Ra) activity., PMID:21965679
Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis., PMID:21881584
IL-1F5, -F6, -F8, and -F9: a novel IL-1 family signaling system that is active in psoriasis and promotes keratinocyte antimicrobial peptide expression., PMID:21242515
IL-1 family nomenclature., PMID:20959797
IL-1 gene cluster is not linked to aggressive periodontitis., PMID:20335539