Catalog No.
AHD81701
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate pERTKR-AMC. The specific activity is >30 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser111-Arg617
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P29120
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
PC1, PCSK1, Neuroendocrine convertase 1, Prohormone convertase 1, Proprotein convertase 1, NEC 1, NEC1
Note
For research use only.
Sphingolipid subtypes differentially control proinsulin processing and systemic glucose homeostasis., PMID:36543979
A Novel Somatic Mutation Implicates ATP6V0D1 in Proinsulin Processing., PMID:36694809
Setmelanotide: a promising advancement for pediatric patients with rare forms of genetic obesity., PMID:36722447
Next-generation sequencing of 12 obesity genes in a Portuguese cohort of patients with overweight and obesity., PMID:36775011
Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study., PMID:36822744
Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants., PMID:36864747
Functional differentiation of the ovine preadipocytes -insights from gene expression profiling., PMID:36952056
Birth weight concerning obesity and diabetes gene expression in healthy infants; a case-control study., PMID:36997916
In vitro comparison of whey protein isolate and hydrolysate for their effect on glucose homeostasis markers., PMID:37066543
Identification and Characteristics of Novel Mutations in Nonsyndromic Monogenic Obesity., PMID:37083215
Tissue-Specific Modulation of Gluco- and Growth-Regulatory Factor Abundance by Nesfatin-1 and Nesfatin-1-like Peptide in Goldfish., PMID:37174474
Calnuc-derived nesfatin-1-like peptide is an activator of tumor cell proliferation and migration., PMID:37539786
Identification of genes related to glucose metabolism and analysis of the immune characteristics in Alzheimer's disease., PMID:37619853
Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults., PMID:37761915
Novel regulators of islet function identified from genetic variation in mouse islet Ca2+ oscillations., PMID:37787501
The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile., PMID:37877373
Management of Monogenic and Syndromic Obesity., PMID:37919024
Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children., PMID:38009939
Peak-agnostic high-resolution cis-regulatory circuitry mapping using single cell multiome data., PMID:38084892
Could setmelanotide be the game-changer for acquired hypothalamic obesity?, PMID:38239988
Suppressive action of nesfatin-1 and nesfatin-1-like peptide on cortisol synthesis in human adrenal cortex cells., PMID:38368491
Whole-exome sequencing combined with postoperative data identify c.1614dup (CAMKK2) as a novel candidate monogenic obesity variant., PMID:38469147
Gut Microbiota-Tryptophan Metabolism-GLP-1 Axis Participates in β-Cell Regeneration Induced by Dapagliflozin., PMID:38471012
Unraveling the significance of PPP1R1A gene in pancreatic β-cell function: A study in INS-1 cells and human pancreatic islets., PMID:38574885
Heterologous expression of P9 from Akkermansia muciniphila increases the GLP-1 secretion of intestinal L cells., PMID:38727988
Prognostic implications of STK11 with different mutation status and its relationship with tumor-infiltrating immune cells in non-small cell lung cancer., PMID:38736875
Data-independent acquisition combined with liquid chromatography mass spectrometry technique to detect prognostic protein markers in type I gastric neuroendocrine neoplasm., PMID:38887896
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer's disease., PMID:38987357
New labdane diterpenoids from Alpinia galanga: A new type of GLP-1 secretagogues targeting the PKA-CREB and PI3K-Akt signaling axes., PMID:39031533
Intestinal Nogo-B reduces GLP1 levels by binding to proglucagon on the endoplasmic reticulum to inhibit PCSK1 cleavage., PMID:39122737
Genetics of glucose homeostasis in pregnancy and postpartum., PMID:39180581
Identification and functional validation of rare coding variants in genes linked to monogenic obesity., PMID:39192769
Identification of novel drug targets for osteoarthritis by integrating genetics and proteomes from blood., PMID:39261869
PCSK1N as a Tumor Size Marker and an ER Stress Response Protein in Corticotroph Pituitary Adenomas., PMID:39288010
Pea protein hydrolysate stimulates GLP-1 secretion in NCI-H716 cells via simultaneously activating the sensing receptors CaSR and PepT1., PMID:39302035
Fam3a-mediated prohormone convertase switch in α-cells regulates pancreatic GLP-1 production in an Nr4a2-Foxa2-dependent manner., PMID:39362520
Cystic fibrosis-related diabetes is associated with reduced islet protein expression of GLP-1 receptor and perturbation of cell-specific transcriptional programs., PMID:39463434
Setmelanotide in patients aged 2-5 years with rare MC4R pathway-associated obesity (VENTURE): a 1 year, open-label, multicenter, phase 3 trial., PMID:39549719
Bioinformatical analysis and experimental validation of endoplasmic reticulum stress-related biomarker genes in type 2 diabetes mellitus., PMID:39553470
Modeling corticotroph deficiency with pituitary organoids supports the functional role of NFKB2 in human pituitary differentiation., PMID:39607428
Pathogenic Deep Intronic PCSK1 Variant Causes Proprotein Convertase 1/3 Deficiency in a Family., PMID:39891480
A comprehensive spatio-cellular map of the human hypothalamus., PMID:39910307
Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning., PMID:39948378
Prohormone cleavage prediction uncovers a non-incretin anti-obesity peptide., PMID:40044869
Modulation of satiety hormones by Bacteroides thetaiotaomicron, Bacteroides fragilis and their derivatives., PMID:40044987
Early childhood height, weight, and BMI development in children with monogenic obesity: a European multicentre, retrospective, observational study., PMID:40246357
The Interplay of UCP3 and PCSK1 Variants in Severe Obesity., PMID:40281302
Modeling diabetic alpha cell dysfunction using stem cell-derived alpha cells., PMID:40345205
A transcriptomic and proteomic analysis and comparison of human brain tissue from patients with and without epilepsy., PMID:40350490
(-)-Oleuropein as a Novel Metastatic Castration-Resistant Prostate Cancer Progression and Recurrence Suppressor via Targeting PCSK9-LDLR Axis., PMID:40362754
For research use only. Not for human or drug use.
