Catalog No.
AHD63601
Biological activity
Measured by its ability to inhibit the biological activity of IGF-I or IGF-II on human breast cancer cells (MCF‑7). The ED50 for this effect is 0.5‑1.5 µg/mL in the presence of 14 ng/mL rhIGF-II.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu21-Glu272
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P24593
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IGF-binding protein 5, IGFBP5, Insulin-like growth factor-binding protein 5, IGFBP-5, IBP-5, IBP5
Proteomic analysis of human follicular fluid based on the 4D label free method to identify proteins that may affect oocyte quality in hyperandrogenic PCOS patients., PMID:40444232
IGFBP5 promotes EndoMT and renal fibrosis through H3K18 lactylation in diabetic nephropathy., PMID:40423799
IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance., PMID:40365313
Intratumor HIF-1α modulates production of a cachectic ligand to cause host wasting., PMID:40336592
STMN1-IGFBP5 axis induces senescence and extracellular matrix degradation in nucleus pulposus cells: In vivo and in vitro insights., PMID:40319242
Targeting miR-103a-3p/IGFBP5 axis: a potential therapeutic strategy for gastric cancer progression., PMID:40263134
Myogenic IGFBP5 levels in rhabdomyosarcoma are nourished by mesenchymal stromal cells and regulate growth arrest and apoptosis., PMID:40234830
Changes in the expression pattern of genes affecting the growth and development of mammary tissue in pregnant Saanen goats in response to dietary fats., PMID:40215566
IGFBP5 protein molecule and thyroid hormone in the diagnosis and effect of gestational diabetes., PMID:40185426
Alzheimer's disease-related cortical proteins modify the association of brain insulin signaling with cognitive decline., PMID:40183406
Deciphering the role of IGFBP5 in delaying fibrosis and sarcopenia in aging skeletal muscle: therapeutic implications and molecular mechanisms., PMID:40144669
Multi-omics integration identifies molecular markers and biological pathways for carcass and meat quality traits in Nellore cattle., PMID:40140445
IGF1 Signaling Regulates Neuropeptide Expression in Hypothalamic Neurons Under Physiological and Pathological Conditions., PMID:40105689
Targeting insulin-like growth factor 1 receptor restricts development and severity of secondary lymphedema in mice., PMID:40060910
Schwann cells secrete IGFBP5 to facilitate the growth of keloids., PMID:40049369
IGFBP5 regulates fibrocartilage differentiation and cartilage injury induced by T-2 toxin via blocking IGF-1/IGF-1R signalling., PMID:39932874
IGFBP5 as a Novel Basolateral Secretion Marker in the Retinal Pigment Epithelium., PMID:39930222
Interaction with IGF1 overrides ANXA2-mediated anti-inflammatory functions of IGFBP5 in vivo., PMID:39867883
Temporal and Spatial Metabolic Shifts Revealing the Transition from Ulcerative Colitis to Colitis-Associated Colorectal Cancer., PMID:39840505
Ablation of IGFBP5 expression alleviates neurogenic erectile dysfunction by inducing neurovascular regeneration., PMID:39791587
Single-cell transcriptomic analysis reveals regulative mechanisms of follicular selection and atresia in chicken granulosa cells., PMID:39643375
Multiplexed immunoassay for a serum autoantibody biomarker panel in diagnostic and prognostic prediction of canine mammary tumors., PMID:39639821
IGFBP5 affects cardiomyocyte survival and functional recovery in mice following myocardial ischemia., PMID:39613849
Transcriptomic analysis of melanoma cells reveals an association of α-synuclein with regulation of the inflammatory response., PMID:39511366
IGFALS suppresses hepatocellular carcinoma progression by stabilizing PPAR-γ., PMID:39471694
Integrative 3D genomics with multi-omics analysis and functional validation of genetic regulatory mechanisms of abdominal fat deposition in chickens., PMID:39468045
Effects of Alanyl-Glutamine Dipeptide Supplementation on Growth Performance, Nutrient Digestibility, Digestive Enzyme Activity, Immunity, and Antioxidant Status in Growing Laying Hens., PMID:39457865
Apoptotic vesicles from macrophages exacerbate periodontal bone resorption in periodontitis via delivering miR-143-3p targeting Igfbp5., PMID:39456001
Proteomic Analysis of Human Serum Proteins Adsorbed onto Collagen Barrier Membranes., PMID:39452600
IGFBP5 in osteosarcoma tumorigenesis: Gene expression profile among metastatic and non-metastatic patients., PMID:39442824
IDO1-mediated kynurenine production inhibits IGFBP5 signaling to promote 5-fluorouracil-induced senescence escape and chemoresistance in colorectal cancer., PMID:39417170
Markers of Metabolic Abnormalities in Vitiligo Patients., PMID:39337683
Urinary Biomarkers Associated With Pathogenic Pathways Reflecting Histologic Findings in Lupus Nephritis., PMID:39317671
Insulin-Like Growth Factor-Binding Protein 5 Promotes the Cell Proliferation and Osteogenic Potential of Dental Pulp Stem Cells Dependent on Its Nuclear Localisation Sequence., PMID:39313926
Inhibition of circular JUN prevents the proliferation and invasion of glioblastoma via miR-3064-IGFBP5 axis., PMID:39307884
Genetic analysis of the PAPP-A2 gene and evaluation of free IGF-1, IGFBP-5, and ALS concentrations in a group of 22 patients with idiopathic short stature., PMID:39279312
Association between IGF-1 and IGFBPs in Blood and Follicular Fluid in Dairy Cows Under Field Conditions., PMID:39199904
Dynamic changes in insulin-like growth factor binding protein expression occur between embryonic and early post-hatch development in broiler chickens., PMID:39197338
Two-polarized roles of transcription factor FOSB in lung cancer progression and prognosis: dependent on p53 status., PMID:39164746
Expression of insulin-like growth factor binding protein 5 in the vaginal wall tissues of older women with pelvic organ prolapse., PMID:39112783
Identification of key genes associated with cervical cancer based on bioinformatics analysis., PMID:39060960
Discovery of crucial cytokines associated with deep vein thrombus formation by protein array analysis., PMID:39026176
Pituitary-derived small extracellular vesicles promote liver repair by its cargo miR-143-3p., PMID:39025906
Intestinal mRNA expression profiles associated with mucosal healing in ustekinumab-treated Crohn's disease patients: bioinformatics analysis and prospective cohort validation., PMID:38926732
Identification of novel therapeutic targets for chronic kidney disease and kidney function by integrating multi-omics proteome with transcriptome., PMID:38898508
A novel role of IGFBP5 in the migration, invasion and spheroids formation induced by IGF-I and insulin in MCF-7 breast cancer cells., PMID:38896333
Deletion of endothelial IGFBP5 protects against ischaemic hindlimb injury by promoting angiogenesis., PMID:38886900
Serum IGFBP5 as a predictor of major adverse cardiac events in patients with acute myocardial infarction., PMID:38880418
Mir-204-5p alleviates mitochondrial dysfunction by targeting IGFBP5 in diabetic cataract., PMID:38874707
Integrative analysis of Iso-Seq and RNA-seq data reveals transcriptome complexity and differential isoform in skin tissues of different hair length Yak., PMID:38773419
For research use only. Not for human or drug use.
