Catalog No.
AHC97301
Biological activity
Measured by its binding ability in a functional ELISA. Immobilized recombinant human Activin RIB/ALK‑4 at 2 µg/mL (100 µL/well) can bind recombinant human TDGF1/CRIPTO (Cat #: AHC97301) with a linear range of 0.8-100 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Met1-Thr172
Nature
Recombinant
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P13385
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cripto-1 growth factor, Teratocarcinoma-derived growth factor 1, TDGF1, CRIPTO, Epidermal growth factor-like cripto protein CR1, CRGF
Note
For research use only.
Visualization of sequential conversion of human intermediately reprogrammed stem cells into iPS cells., PMID:31386786
Cripto-1 expression in patients with clear cell renal cell carcinoma is associated with poor disease outcome., PMID:31455359
Cripto-1 localizes to dynamic and shed filopodia associated with cellular migration in glioblastoma cells., PMID:31543278
Detection of small numbers of iPSCs in different heterogeneous cell mixtures with highly sensitive droplet digital PCR., PMID:31578676
KRAS mutation and abnormal expression of Cripto-1 as two potential candidate biomarkers for detection of colorectal cancer development., PMID:31692030
Derivation of notochordal cells from human embryonic stem cells reveals unique regulatory networks by single cell-transcriptomics., PMID:31840817
Prognostic value of cripto-1 expression in non-small-cell lung cancer patients: a systematic review and meta-analysis., PMID:32134335
The Function and Prognostic Significance of Cripto-1 in Colorectal Cancer., PMID:32157913
Structure-based design of small bicyclic peptide inhibitors of Cripto-1 activity., PMID:32215602
Zebrafish Microenvironment Elevates EMT and CSC-Like Phenotype of Engrafted Prostate Cancer Cells., PMID:32225005
Proteomic analysis of the cardiac myocyte secretome reveals extracellular protective functions for the ER stress response., PMID:32339566
Cripto-1 promotes tumor invasion and predicts poor outcomes in hepatocellular carcinoma., PMID:32648918
Cripto-1 promotes tumor invasion and predicts poor outcomes in hepatocellular carcinoma., PMID:32649753
A Prognostic Model Based on the Immune-related Genes in Colon Adenocarcinoma., PMID:32788867
PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins., PMID:32816994
MasterPATH: network analysis of functional genomics screening data., PMID:32928103
E2A regulates neural ectoderm fate specification in human embryonic stem cells., PMID:33144398
CRIPTO antagonist ALK4L75A-Fc inhibits breast cancer cell plasticity and adaptation to stress., PMID:33187540
Gastruloid Development Competence Discriminates Different States of Pluripotency., PMID:33482102
A Novel Artificially Humanized Anti-Cripto-1 Antibody Suppressing Cancer Cell Growth., PMID:33567764
Maternal Cripto is required for proper uterine decidualization and peri-implantation uterine remodeling., PMID:33590845
Maternal Cripto is critical for proper development of the mouse placenta and the placental vasculature., PMID:33730615
[Expression and Prognostic Value of Cripto-1 in Pancreatic Cancer]., PMID:33966694
The pattern of nodal morphogen signaling is shaped by co-receptor expression., PMID:34036935
Cripto favors chondrocyte hypertrophy via TGF-β SMAD1/5 signaling during development of osteoarthritis., PMID:34357595
Investigating the role of EGF-CFC gene family in recurrent pregnancy loss through bioinformatics and molecular approaches., PMID:34498535
Cripto-1 as a Key Factor in Tumor Progression, Epithelial to Mesenchymal Transition and Cancer Stem Cells., PMID:34502188
Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways., PMID:34517344
miR-3929 Inhibits Proliferation and Promotes Apoptosis by Downregulating Cripto-1 Expression in Cervical Cancer Cells., PMID:34569498
Whence CRIPTO: The Reemergence of an Oncofetal Factor in 'Wounds' That Fail to Heal., PMID:34576327
Oncofetal Protein CRIPTO Is Involved in Wound Healing and Fibrogenesis in the Regenerating Liver and Is Associated with the Initial Stages of Cardiac Fibrosis., PMID:34943832
CRIPTO-1 Is Immunolocalized in the Syncytiotrophoblast of Ampullary Pregnancies., PMID:35434129
The Impact of Activin A on Fetal Gonocytes: Chronic Versus Acute Exposure Outcomes., PMID:35721752
GWAS of Chronic Spontaneous Urticaria Reveals Genetic Overlap with Autoimmune Diseases, Not Atopic Diseases., PMID:35933036
Regulation of Nodal signaling propagation by receptor interactions and positive feedback., PMID:36149406
Liver receptor homolog 1 (LRH-1) regulates follicle vasculature during ovulation in mice., PMID:36173805
Pseudogene TDGF1P3 regulates the proliferation and metastasis of colorectal cancer cells via the miR-338-3p-PKM2 axis., PMID:36436343
Testicular Germ Cell Tumor Tissue Biomarker Analysis: A Comparison of Human Protein Atlas and Individual Testicular Germ Cell Tumor Component Immunohistochemistry., PMID:37508506
Cripto Is Targeted by miR-1a-3p in a Mouse Model of Heart Development., PMID:37569627
CRIPTO-based micro-heterogeneity of mouse muscle satellite cells enables adaptive response to regenerative microenvironment., PMID:38056454
Recombinant humanized Fab fragments targeting the CFC domain of human Cripto-1., PMID:38150919
Exploring biomarkers in trigeminal neuralgia patients operated with microvascular decompression: A comparison with multiple sclerosis patients and non-neurological controls., PMID:38158702
Lineage regulators TFAP2C and NR5A2 function as bipotency activators in totipotent embryos., PMID:38243114
Human Genetics of Ventricular Septal Defect., PMID:38884729
Decrypting the phylogenetics history of EGF-CFC proteins Cripto and Cryptic., PMID:39257814
CRIPTO's multifaceted role in driving aggressive prostate cancer unveiled by in vivo, organoid, and patient data., PMID:39592836
Protogenin facilitates trunk-to-tail HOX code transition via modulating GDF11/SMAD2 signaling in mammalian embryos., PMID:39702818
Cripto-1 acts as a molecular bridge linking nodal to ALK4 via distinct structural domains., PMID:39840816
Inhibition of Fin Regeneration in Fathead Minnow (Pimephales promelas) by a Potent Synthetic Glucocorticoid and Development of Adverse Outcome Pathway 334., PMID:40326831
In silico prediction of GRP78-CRIPTO binding sites to improve therapeutic targeting in glioblastoma., PMID:40360533
For research use only. Not for human or drug use.
