Catalog No.
AHC73301
Biological activity
Measured by its ability to cleave the fluorogenic peptide substrate, Mca-RPPGFSAFK(Dnp)-OH. The specific activity is > 250 pmol/min/µg, as measured under the described conditions.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Gln104-Ser787
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P0DPD6
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Endothelin-converting enzyme 2, KIAA0604, ECE2, ECE-2
Identification of ECE2 signaling in promoting non-small lung cancer progression through ET1/YAP1/MAGEA3 axis., PMID:39955423
Identification of potential differences in salivary proteomic profiles between estrus and diestrus stage of estrous cycle in dairy cows., PMID:39008339
Anisomycin inhibits the activity of human ovarian cancer stem cells via regulating antisense RNA NCBP2-AS2/MEK/ERK/STAT3 signaling., PMID:37483091
Mutation analysis of the ECE1 gene in late-onset Alzheimer's disease., PMID:37271044
Identification of novel candidate genes for age at first calving in Nellore cows using a SNP chip specifically developed for Bos taurus indicus cattle., PMID:34392169
Ligand-specific recycling profiles determine distinct potential for chronic analgesic tolerance of delta-opioid receptor (DOPr) agonists., PMID:32279433
ECE2 regulates neurogenesis and neuronal migration during human cortical development., PMID:32207244
Identification of Alzheimer's disease-associated rare coding variants in the ECE2 gene., PMID:32102983
CA1 pyramidal neuron gene expression mosaics in the Ts65Dn murine model of Down syndrome and Alzheimer's disease following maternal choline supplementation., PMID:29394516
Identification of endothelin-converting enzyme-2 as an autoantigen in autoimmune polyendocrine syndrome type 1., PMID:28557628
A novel TCF7L2 type 2 diabetes SNP identified from fine mapping in African American women., PMID:28253288
Microenvironment-derived factors driving metastatic plasticity in melanoma., PMID:28181494
Endothelin-converting enzymes degrade α-synuclein and are reduced in dementia with Lewy bodies., PMID:28171705
The effect of fluvastatin on cardiac fibrosis and angiotensin-converting enzyme-2 expression in glucose-controlled diabetic rat hearts., PMID:28013371
Major amyloid-β-degrading enzymes, endothelin-converting enzyme-2 and neprilysin, are expressed by distinct populations of GABAergic interneurons in hippocampus and neocortex., PMID:27644077
GPER is required for the age-dependent upregulation of the myocardial endothelin system., PMID:26880534
Pathophysiology of Hypoperfusion of the Precuneus in Early Alzheimer's Disease., PMID:26452729
Mutational landscape of intrahepatic cholangiocarcinoma., PMID:25526346
Transcriptional alterations of ET-1 axis and DNA damage in lung tissue of a rat obesity model., PMID:25517973
Endothelin as a local regulating factor in the bovine oviduct., PMID:25370848
Endothelin and vascular remodelling in colitis pathogenesis--appendicitis and appendectomy limit colitis by suppressing endothelin pathways., PMID:25085204
Endothelin-converting enzyme 2 differentially regulates opioid receptor activity., PMID:24990314
Opioid receptor function is regulated by post-endocytic peptide processing., PMID:24847082
The profibrotic role of endothelin-1: is the door still open for the treatment of fibrotic diseases?, PMID:24378671
Endothelin-converting enzyme-1 activity, endothelin-1 production, and free radical-dependent vasoconstriction in Alzheimer's disease., PMID:23629587
Endothelin-converting enzymes degrade intracellular β-amyloid produced within the endosomal/lysosomal pathway and autophagosomes., PMID:23283972
The role of ECE1 variants in cognitive ability in old age and Alzheimer's disease risk., PMID:22693153
Endothelin-1 is elevated in Alzheimer's disease and upregulated by amyloid-β., PMID:22330820
The influence of tumour necrosis factor- α (TNF-α) on amyloid-β (Aβ)-degrading enzymes in vitro., PMID:22200003
Genetic analysis of genes involved in amyloid-β degradation and clearance in Alzheimer's disease., PMID:22027013
Mice deficient in endothelin-converting enzyme-2 exhibit abnormal responses to morphine and altered peptide levels in the spinal cord., PMID:21972895
Multiple cellular and molecular mechanisms are involved in human Aβ clearance by transplanted adult astrocytes., PMID:21826742
Expression pattern of endothelin system components and localization of smooth muscle cells in the human pre-ovulatory follicle., PMID:21406445
Endothelin receptor antagonists: potential in Alzheimer's disease., PMID:21193044
Identification of an endothelin-converting enzyme-2-specific fluorigenic substrate and development of an in vitro and ex vivo enzymatic assay., PMID:20807771
Production and binding of endothelin-2 (EDN2) in the rat ovary: endothelin receptor subtype A (EDNRA)-mediated contraction., PMID:20450830
Endothelin-converting enzyme-1 in Alzheimer's disease and vascular dementia., PMID:20345647
Transdifferentiation potentiality of human Wharton's jelly stem cells towards vascular endothelial cells., PMID:20143331
Endothelin-converting enzyme-2 is increased in Alzheimer's disease and up-regulated by Abeta., PMID:19541930
Pathophysiology of the endothelin system - lessons from genetically manipulated animal models., PMID:19258203
An intact SAM-dependent methyltransferase fold is encoded by the human endothelin-converting enzyme-2 gene., PMID:19089949
Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory., PMID:21450041
Homology modeling and site-directed mutagenesis to identify selective inhibitors of endothelin-converting enzyme-2., PMID:18507370
Abeta-degrading enzymes in Alzheimer's disease., PMID:18363935
Endothelin-converting enzyme-1 degrades internalized somatostatin-14., PMID:18276747
Bioinformatic analysis of the neprilysin (M13) family of peptidases reveals complex evolutionary and functional relationships., PMID:18215274
Meta-analysis of whole-genome linkage scans for intracranial aneurysm., PMID:18069126
Association of single nucleotide polymorphisms in endothelin family genes with the progression of atherosclerosis in patients with essential hypertension., PMID:17525706
Alterations in immunological and neurological gene expression patterns in Alzheimer's disease tissues., PMID:17188679
Endothelin., PMID:16999223
For research use only. Not for human or drug use.
