Catalog No.
AHC33101
Biological activity
Measured by its ability to induce hemoglobin expression in human chronic myelogenous leukemia cells (K562). The ED50 for this effect is 0.200-1.60 ng/mL.
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Ser21-Ser426
Nature
Recombinant
Endotoxin level
<0.1 EU/μg of the protein by the LAL method.
Purity
>90% as determined by SDS-PAGE.
Accession
P08476
Applications
Bioactivity, ELISA, Immunogen, SDS-PAGE, WB
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
EDF, Erythroid differentiation protein, Activin beta-A chain, INHBA, Inhibin beta A chain
Hypoxia Exposure Promotes Th17 Cell Differentiation Through Activin A-PKM2 Axis to Exacerbate Autoimmune and Autoinflammatory Diseases., PMID:40515525
Efficient Generation of Induced Pluripotent Stem Cell-Derived Definitive Endoderm Cells with Growth Factors and Small Molecules., PMID:40497991
Activin A exacerbates neonatal necrotizing enterocolitis via ALK4-mediated apoptosis and barrier disruption., PMID:40494204
Ligand-specific regulation of a binary enhancer code dictating cellular senescence., PMID:40493192
Combined detection of inhibitors of the activin receptor signaling pathways (IASPs) by means of LC-HRMS/MS for human doping control., PMID:40481031
Development of a 3D ex vivo model of brain-leukemia interaction to study the role of activin A in the central nervous system microenvironment., PMID:40442333
DEHP exposure alters carcinoembryonic antigen family member transcript levels and modulates responses to activin A in the murine placenta., PMID:40435666
Combined rapamycin and mesenchymal stem/stromal cells derived from induced pluripotent stem cells-mediated delivery of ACVR2B-Fc fusion protein reduces heterotopic ossification in a mouse model of fibrodysplasia ossificans progressiva., PMID:40416557
Lipopolysaccharide induces retention of E-cadherin in the endoplasmic reticulum and promotes hybrid epithelial-to-mesenchymal transition of human embryonic stem cells-derived expandable lung epithelial cells., PMID:40413286
Sex-chromosome complement and Activin-A shape the therapeutic potential of TNFR2 activation in a model of MS and CNP., PMID:40378000
Transforming growth factor beta-related proteins promote axonal regeneration of injured dorsal root ganglion neurons., PMID:40364649
GDF8 and activin A blockade protects against GLP-1-induced muscle loss while enhancing fat loss in obese male mice and non-human primates., PMID:40360507
GDF8 and activin A are the key negative regulators of muscle mass in postmenopausal females: a randomized phase I trial., PMID:40360471
Activin-A Regulates Bone Morphogenetic Protein Signaling in Pulmonary Endothelial Cells Without Affecting Bone Morphogenetic Protein Type-II Receptor Expression., PMID:40330556
Impact of pre-transplant serum levels of activin A, activin B, IGF-1 and IL-6 on transplant outcomes and survival in patients with multiple myeloma: a prospective study., PMID:40322823
A Facile Surface Modification Strategy for Antibody Immobilization on 3D-Printed Surfaces., PMID:40277525
Advancements in mechanisms and drug treatments for fibrodysplasia ossificans progressiva., PMID:40274382
Activin A is deeply involved in the progression of sarcopenia and leads to poor prognosis in lung cancer patients., PMID:40254615
Explosive cytotoxicity of 'ruptoblasts' bridges hormonal surveillance and immune defense., PMID:40236000
Fibrodysplasia ossificans progressiva: genetic and clinical characterization in a cohort of Polish patients and review of potential therapies., PMID:40220125
Impact of Excess Activin A on the Lipids, Metabolites, and Steroids of Adult Mouse Reproductive Organs., PMID:40209098
Development of animal models with chronic kidney disease-mineral and bone disorder based on clinical characteristics and pathogenesis., PMID:40201764
Pediatric Pulmonary Hypertension is Associated With Increased Circulating Levels of BMP 7 and CHIP., PMID:40182212
Expression and distribution of activin-follistatin-inhibin axis in the urinary bladder., PMID:40144023
Activin A Inhibitory Peptides Suppress Fibrotic Pathways by Targeting Epithelial-Mesenchymal Transition and Fibroblast-Myofibroblast Transformation in Idiopathic Pulmonary Fibrosis., PMID:40141346
INHBA, transcriptionally activated by SPI1, facilitates gastric cancer progression by inducing macrophage recruitment and M2 polarization via activating the TGF-β signaling to increase CCL2., PMID:40132395
EGFR-mediated local invasiveness and response to Cetuximab in head and neck cancer., PMID:40121428
Enhancing human NK cell antitumor function by knocking out SMAD4 to counteract TGFβ and activin A suppression., PMID:40119192
Activin-A urine levels correlate with radiological patterns in preterm infants complicated by intraventricular hemorrhage., PMID:40114243
Activin a regulates vascular formation and stabilization in direct coculture of dental pulp stem cells and endothelial cells., PMID:40106315
Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells., PMID:40082306
Circulating follistatin-like 3 and its association with postpartum cardiovascular dysfunction and severe maternal morbidity., PMID:40081190
Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner., PMID:40075112
Activin A activation of Smad3 mitigates innate inflammation in mouse models of psoriasis and sepsis., PMID:40067393
Platelet-Derived Growth Factor Promotes Glomerular Mesangial Cells Differentiation of Human Bone Marrow Hematopoietic Stem Cells - An In Vitro Study., PMID:40065657
Kallikrein-8 mediates furin-independent Activin-A precursor processing to stimulate tumor growth in melanoma., PMID:40064965
Targeted Therapies in Myelofibrosis: Present Landscape, Ongoing Studies, and Future Perspectives., PMID:40062529
Biomarkers of cellular senescence predict risk of mild cognitive impairment: Results from the lifestyle interventions for elders (LIFE) study., PMID:40056496
Emerging Pathogenetic Mechanisms and New Drugs for Anemia in Myelofibrosis and Myelodysplastic Syndromes., PMID:40056069
Effect of sufentanil on the proliferation, apoptosis, and epithelial-mesenchymal transition of ovarian cancer cells by regulating the SMAD3/SNAIL signaling pathway., PMID:40032693
Molecular Markers of Occult Lymph Node Metastasis in Head and Neck Squamous Cell Carcinoma (HNSCC) Patients., PMID:40018925
Short-term overloading exercise attenuates articular chondrocyte features partly via synovium-cartilage interactions mediated by inhibin subunit beta A., PMID:40000838
Propagation of goose primordial germ cells in vitro relies on FGF and BMP signalling pathways., PMID:40000797
X-Linked Gene Dosage and SOX2 Act as Key Roadblocks for Human Germ Cell Specification in Klinefelter Syndrome., PMID:39996497
ActRII or BMPR ligands inhibit skeletal myoblast differentiation, and BMPs promote heterotopic ossification in skeletal muscles in mice., PMID:39994804
Assessing genetic conservation of human sociability-linked genes in C. elegans., PMID:39982572
Activity-dependent regulation of microglia numbers by pyramidal cells during development shape cortical functions., PMID:39970202
Difference of the gut microbiota of premature ovarian insufficiency in two traditional Chinese syndromes., PMID:39957167
Sox9 inhibits Activin A to promote biliary maturation and branching morphogenesis., PMID:39955269
Decoupling chemical and mechanical signaling in colorectal cancer cell migration., PMID:39929899
For research use only. Not for human or drug use.
