Recombinant Human CD170/SIGLEC5 Protein, C-hFc-His (Active)

Catalog No.

AHA51201

Biological activity

Measured by the ability of the immobilized protein to support the adhesion of human red blood cells.The ED50 for this effect is 1‑4 µg/mL.

Expression system

Mammalian Cells

Species

Homo sapiens (Human)

Protein length

Glu17-Thr434

Nature

Recombinant

Endotoxin level

<0.1 EU/μg of the protein by the LAL method.

Purity

>90% as determined by SDS-PAGE.

Accession

O15389

Applications

Bioactivity, ELISA, Immunogen, SDS-PAGE, WB

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

CD33 antigen-like 2, Obesity-binding protein 2, OBBP2, Siglec-5, CD170, OB-binding protein 2, Sialic acid-binding Ig-like lectin 5, OB-BP2, SIGLEC5, CD33L2

The immunomodulatory ballet of tumour-derived extracellular vesicles and neutrophils orchestrating the dynamic CD73/PD-L1 pathway in cancer., PMID:38978304

Invariant natural killer T cells drive hepatic homeostasis in nonalcoholic fatty liver disease via sustained IL-10 expression in CD170+ Kupffer cells., PMID:37489253

Expression profiles of novel cell surface molecules on B-cell subsets and plasma cells as analyzed by flow cytometry., PMID:20951740

Amicrobial pustulosis of the folds associated with auto-immune disorders. A case report with an analysis of cytokine expression profile in skin lesions of cutaneous neutrophilic lupus., PMID:18230981

Structural implications of Siglec-5-mediated sialoglycan recognition., PMID:18022638

Siglec-5 (CD170) can mediate inhibitory signaling in the absence of immunoreceptor tyrosine-based inhibitory motif phosphorylation., PMID:15769739

Identification of the CD33-related Siglec receptor, Siglec-5 (CD170), as a useful marker in both normal myelopoiesis and acute myeloid leukaemias., PMID:14617000

Characterization of Siglec-5 (CD170) expression and functional activity of anti-Siglec-5 antibodies on human phagocytes., PMID:12763136

Detection of novel CD antigens on the surface of human mast cells and basophils., PMID:12021549

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