Catalog No.
YHD98801
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg243-Arg333
Predicted molecular weight
12.00 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P32239
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Cholecystokinin-2 receptor, CCK2-R, CCK-BR, CCK-B receptor, Gastrin/cholecystokinin type B receptor, CCKBR, CCKRB
Gastrointestinal cholecystokinin signaling pathway drugs modulate osteogenic/cementogenic differentiation of human periodontal ligament stem cells., PMID:40032153
Intestinal Gastrin/CCKBR Axis Protects against Type 2 Diabetes by Reducing Intestinal Glucose Absorption through the PI3K/Akt/eIF4B Signaling Pathway., PMID:39950948
Kidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway., PMID:39721589
[Study on the antihypertensive mechanism of acupuncture at "Renying" (ST9) and "Zusanli" (ST36) via gastrin/cholecystokinin B receptors]., PMID:39433364
Unraveling the role of cholecystokinin in epilepsy: Mechanistic insight into neuroplasticity., PMID:39343303
CCKBR+ cancer cells contribute to the intratumor heterogeneity of gastric cancer and confer sensitivity to FOXO inhibition., PMID:39164456
Cholecystokinin neurotransmission in the central nervous system: Insights into its role in health and disease., PMID:38777339
Cholecystokinin-mediated effect of insulin pathway on the steroidogenic activity of follicular granulosa cells in Camelus bactrianus: In vitro study., PMID:38757644
Cholecystokinin B receptor agonists alleviates anterograde amnesia in cholecystokinin-deficient and aged Alzheimer's disease mice., PMID:38750512
Cholecystokinin facilitates motor skill learning by modulating neuroplasticity in the motor cortex., PMID:38700136
Comprehensive multi-omics analysis of resectable locally advanced gastric cancer: Assessing response to neoadjuvant camrelizumab and chemotherapy in a single-center, open-label, single-arm phase II trial., PMID:38685486
A Cholecystokinin Analogue Ameliorates Cognitive Deficits and Regulates Mitochondrial Dynamics via the AMPK/Drp1 Pathway in APP/PS1 Mice., PMID:38374745
Implicating the cholecystokinin B receptor in liver stem cell oncogenesis., PMID:38252699
Elevated Serum Gastrin Is Associated with Melanoma Progression: Putative Role in Increased Migration and Invasion of Melanoma Cells., PMID:38069171
Epigenetic HDAC5 Inhibitor Reverses Craniofacial Neuropathic Pain in Mice., PMID:37777035
Deterioration of apatite orientation in the cholecystokinin B receptor gene (Cckbr)-deficient mouse femurs., PMID:37676507
Effect of GRK4 on renal gastrin receptor regulation in hypertension., PMID:37641972
Intestinal Cckbr-specific knockout mouse as a novel model of salt-sensitive hypertension via sodium over-absorption., PMID:37576480
Rapid Generation and Molecular Docking Analysis of Single-Chain Fragment Variable (scFv) Antibody Selected by Ribosome Display Targeting Cholecystokinin B Receptor (CCK-BR) for Reduction of Chronic Neuropathic Pain., PMID:37446213
Cholecystokinin B receptor antagonists for the treatment of depression via blocking long-term potentiation in the basolateral amygdala., PMID:37365241
Cholecystokinin Signaling can Rescue Cognition and Synaptic Plasticity in the APP/PS1 Mouse Model of Alzheimer's Disease., PMID:37247071
Integrated bioinformatics analysis for exploring hub genes and related mechanisms affecting the progression of gastric cancer., PMID:37243583
Treatment with a Cholecystokinin Receptor Antagonist, Proglumide, Improves Efficacy of Immune Checkpoint Antibodies in Hepatocellular Carcinoma., PMID:36835036
DNA-methylation and immunological response in medication overuse headache., PMID:36786322
Signaling Network Response to α-Particle-Targeted Therapy with the 225Ac-Labeled Minigastrin Analog 225Ac-PP-F11N Reveals the Radiosensitizing Potential of Histone Deacetylase Inhibitors., PMID:36732057
Target-Specific Nanoparticle Polyplex Down-Regulates Mutant Kras to Prevent Pancreatic Carcinogenesis and Halt Tumor Progression., PMID:36614194
Cholecystokinin Receptor Antagonist Suppresses Melanoma Growth by Inducing Apoptosis of Tumor Cells., PMID:36262666
Cysteine protease of Clonorchis sinensis alleviates DSS-induced colitis in mice., PMID:36084127
Plant-Based Meat Analogues Weaken Gastrointestinal Digestive Function and Show Less Digestibility Than Real Meat in Mice., PMID:36070521
Comparative analysis of cancer cell responses to targeted radionuclide therapy (TRT) and external beam radiotherapy (EBRT)., PMID:36045419
Intestinal Gastrin/CCKBR (Cholecystokinin B Receptor) Ameliorates Salt-Sensitive Hypertension by Inhibiting Intestinal Na+/H+ Exchanger 3 Activity Through a PKC (Protein Kinase C)-Mediated NHERF1 and NHERF2 Pathway., PMID:35674015
The expression of the gastrin/cholecystokinin (GAST/CCK) family and their receptors (CCKAR/CCKBR) in the chicken changes in response to quantitative restriction and reveals a functional role of CCK in the crop., PMID:35292263
Downregulation of CCKBR Expression Inhibits the Proliferation of Gastric Cancer Cells, Revealing a Potential Target for Immunotoxin Therapy., PMID:34994328
Cholecystokinin-B Receptor-Targeted Nanoparticle for Imaging and Detection of Precancerous Lesions in the Pancreas., PMID:34944412
Cholecystokinin B receptor gene polymorphism (rs2941026) is associated with anxious personality and suicidal thoughts in a longitudinal study., PMID:34924075
A lipid metabolism-related genes prognosis biomarker associated with the tumor immune microenvironment in colorectal carcinoma., PMID:34740325
Differences in and verification of genetic alterations in chemotherapy and immunotherapy for metastatic melanoma., PMID:34675134
Structures of the human cholecystokinin receptors bound to agonists and antagonists., PMID:34556863
Aptamer-Targeted Calcium Phosphosilicate Nanoparticles for Effective Imaging of Pancreatic and Prostate Cancer., PMID:33776434
GWAS of peptic ulcer disease implicates Helicobacter pylori infection, other gastrointestinal disorders and depression., PMID:33608531
Gonadal Cycle-Dependent Expression of Genes Encoding Peptide-, Growth Factor-, and Orphan G-Protein-Coupled Receptors in Gonadotropin- Releasing Hormone Neurons of Mice., PMID:33551743
Identification of potential biomarkers for abdominal pain in IBS patients by bioinformatics approach., PMID:33530940
Gastrin, via activation of PPARα, protects the kidney against hypertensive injury., PMID:33458737
Cholecystokinin peptide signaling is regulated by a TBX5-MEF2 axis in the heart., PMID:33249116
Targeting the Cholecystokinin Receptor: A Novel Approach for Treatment and Prevention of Hepatocellular Cancer., PMID:33115780
Activation of multiple receptors stimulates extracellular vesicle release from trophoblast cells., PMID:33080118
Deletion of the Gene Encoding the NMDA Receptor GluN1 Subunit in Schwann Cells Causes Ultrastructural Changes in Remak Bundles and Hypersensitivity in Pain Processing., PMID:33051351
Pharmacological inhibition of mTORC1 increases CCKBR-specific tumor uptake of radiolabeled minigastrin analogue [177Lu]Lu-PP-F11N., PMID:33042258
Influence of hypergastrinemia secondary to long-term proton pump inhibitor treatment on ECL cell tumorigenesis in human gastric mucosa., PMID:32853950
Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation., PMID:32159971
For research use only. Not for human or drug use.
