Investigational IGF1R inhibitors in early stage clinical trials for cancer therapy., PMID:31731883
Insulin-like growth factor (IGF)-II- mediated fibrosis in pathogenic lung conditions., PMID:31765403
A Phase I Trial of IGF-1R Inhibitor Cixutumumab and mTOR Inhibitor Temsirolimus in Metastatic Castration-resistant Prostate Cancer., PMID:32057715
TSH/IGF1 receptor crosstalk: Mechanism and clinical implications., PMID:32061922
IGF-1R drugs travel from cancer cradle to Graves'., PMID:32265558
Targeting the IGF-Axis for Cancer Therapy: Development and Validation of an IGF-Trap as a Potential Drug., PMID:32365498
Teprotumumab: a novel therapeutic monoclonal antibody for thyroid-associated ophthalmopathy., PMID:32429706
IGF-1 receptor activity in the Golgi of migratory cancer cells depends on adhesion-dependent phosphorylation of Tyr1250 and Tyr1251., PMID:32457113
PSPC1 Potentiates IGF1R Expression to Augment Cell Adhesion and Motility., PMID:32570949
Putative protective role of autoantibodies against the insulin-like growth factor-1 receptor in Graves' Disease: results of a pilot study., PMID:32583374
Phase 1b Study of IGF-Methotrexate Conjugate in the Treatment of High-grade Myelodysplastic Syndromes., PMID:32620628
Differential expression of receptors mediating receptor-mediated transcytosis (RMT) in brain microvessels, brain parenchyma and peripheral tissues of the mouse and the human., PMID:32698806
A homogeneous immunoassay for detection of the interaction between two tumor biomarkers of IGF1R-β and SOCS1., PMID:32700452
Endothelial deficiency of insulin-like growth factor-1 receptor reduces endothelial barrier function and promotes atherosclerosis in Apoe-deficient mice., PMID:32795184
Is there a role for insulin-like growth factor inhibition in the treatment of COVID-19-related adult respiratory distress syndrome?, PMID:32795835
Is There Evidence for IGF1R-Stimulating Abs in Graves' Orbitopathy Pathogenesis?, PMID:32911689
Strategic Aspects of NPY-Based Monoclonal Antibodies for Diagnosis and Treatment of Breast Cancer., PMID:32951575
Inhibition of G Protein-Coupled Receptor Kinase 2 Promotes Unbiased Downregulation of IGF1 Receptor and Restrains Malignant Cell Growth., PMID:33158816
mTOR kinase inhibition disrupts neuregulin 1-ERBB3 autocrine signaling and sensitizes NF2-deficient meningioma cellular models to IGF1R inhibition., PMID:33273014
Teprotumumab as a Novel Therapy for Thyroid-Associated Ophthalmopathy., PMID:33391187
Disrupting Insulin and IGF Receptor Function in Cancer., PMID:33429867
An expanded genetic code facilitates antibody chemical conjugation involving the lambda light chain., PMID:33561746
Orbital inflammatory disorders: new knowledge, future challenges., PMID:33606408
Defining the epitope of a blood-brain barrier crossing single domain antibody specific for the type 1 insulin-like growth factor receptor., PMID:33608571
Lessons Learned from Targeting IGF-I Receptor in Thyroid-Associated Ophthalmopathy., PMID:33673340
Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes., PMID:33749521
Teprotumumab: The Dawn of Therapies in Moderate-to-Severe Thyroid-Associated Ophthalmopathy., PMID:33853117
Switchable CAR-T Cells Outperformed Traditional Antibody-Redirected Therapeutics Targeting Breast Cancers., PMID:33856201
IGF-1R anti-idiotypic antibody antagonist exhibited anti-ovarian cancer bioactivity and reduced cisplatin resistance., PMID:33905103
Cytokines as Targets of Novel Therapies for Graves' Ophthalmopathy., PMID:33935970
Disruption of FOXO3a-miRNA feedback inhibition of IGF2/IGF-1R/IRS1 signaling confers Herceptin resistance in HER2-positive breast cancer., PMID:33976188
miR-301a-3p induced by endoplasmic reticulum stress mediates the occurrence and transmission of trastuzumab resistance in HER2-positive gastric cancer., PMID:34257270
Thyroid-related ophthalmopathy development in concurrence with growth hormone administration., PMID:34412613
Physiologic IGFBP7 levels prolong IGF1R activation in acute lymphoblastic leukemia., PMID:34438446
MiR-98-5p/IGF2 Axis Influence Herceptin Sensitivity through IGF1R/HER2 Heterodimer Formation and AKT/mTOR Signal Pathway in HER2 Positive Breast Cancer., PMID:34837929
Therapeutic IGF-I receptor inhibition alters fibrocyte immune phenotype in thyroid-associated ophthalmopathy., PMID:34949642
[Dihydromyricetin reverses Herceptin resistance by up-regulating miR-98-5p and inhibiting IGF1R/HER2 dimer formation in SKBR3 cells]., PMID:35365444
Activating IGF1R hotspot non-frameshift insertions define a novel, potentially targetable molecular subtype of adenoid cystic carcinoma., PMID:35970994
IGF1R signalling is a guardian of self-tolerance restricting autoantibody production., PMID:36105797
IGFBP7 Fuels the Glycolytic Metabolism in B-Cell Precursor Acute Lymphoblastic Leukemia by Sustaining Activation of the IGF1R-Akt-GLUT1 Axis., PMID:37298628
Insulin-like growth factor-1 receptor crosstalk with integrins, cadherins, and the tumor microenvironment: sticking points in understanding IGF1R function in cancer., PMID:37490874
GWAS-identified hyperuricemia-associated IGF1R variant rs6598541 has a limited role in urate mediated inflammation in human mononuclear cells., PMID:38347000
PAPP-A as a Potential Target in Thyroid Eye Disease., PMID:38752390
TSHR-IGF-IR complex drives orbital fibroblast misbehavior in thyroid eye disease., PMID:39082947
CHS-Ⅳa activates the IGF1R/PI3K signal pathway with inhibited pyroptosis of endometrial stromal cells and progress of endometriosis., PMID:39488924
Advances of IGF-1R inhibitors in Graves' ophthalmopathy., PMID:39578269
Linsitinib inhibits proliferation and induces apoptosis of both IGF-1R and TSH-R expressing cells., PMID:39723207
Effects of linsitinib on M22 and IGF:1-treated 3D spheroids of human orbital fibroblasts., PMID:39747159
Mechanisms in Thyroid Eye Disease: The TSH Receptor Interacts Directly With the IGF-1 Receptor., PMID:39821041
Controversies Surrounding IGF-I Receptor Involvement in Thyroid-Associated Ophthalmopathy., PMID:39909461
For research use only. Not for human or drug use.
