Catalog No.
YHB23901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Thr2-Leu89
Predicted molecular weight
12.24 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75531
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Barrier-to-autointegration factor, Breakpoint cluster region protein 1, BANF1, BCRG1, BAF
VRK1/BANF1/GLI1 Axis Regulates Tumor Development and Progression of Colorectal Cancer., PMID:40384864
Cryo-EM structures of the BAF-Lamin A/C complex bound to nucleosomes., PMID:39929866
BANF1 is a novel prognostic biomarker linked to immune infiltration in head and neck squamous cell carcinoma., PMID:39439799
A human progeria-associated BAF-1 mutation modulates gene expression and accelerates aging in C. elegans., PMID:39367234
Molecular functions of ANKLE2 and its implications in human disease., PMID:38691001
Pathogenic effects of Leu200Pro and Arg387His VRK1 protein variants on phosphorylation targets and H4K16 acetylation in distal hereditary motor neuropathy., PMID:38554151
Strophanthidin Induces Apoptosis of Human Lung Adenocarcinoma Cells by Promoting TRAIL-DR5 Signaling., PMID:38398629
Identification of BANF1 as a novel prognostic biomarker in gastric cancer and validation via in-vitro and in-vivo experiments., PMID:38261746
PYCR1, BANF1, and STARD8 Expression in Gastric Carcinoma: A Clinicopathologic, Prognostic, and Immunohistochemical Study., PMID:37982568
Unfolded protein response pathways in stroke patients: a comprehensive landscape assessed through machine learning algorithms and experimental verification., PMID:37891634
BANF1 promotes glutamate-induced apoptosis of HT-22 hippocampal neurons., PMID:37838622
Nuclear lamin A-associated proteins are required for centromere assembly., PMID:37808683
A disordered region controls cBAF activity via condensation and partner recruitment., PMID:37788668
Mono-phosphorylation at Ser4 of barrier-to-autointegration factor (Banf1) significantly reduces its DNA binding capability by inducing critical changes in its local conformation and DNA binding surface., PMID:37665626
Inhibition of tumor intrinsic BANF1 activates antitumor immune responses via cGAS-STING and enhances the efficacy of PD-1 blockade., PMID:37620043
Decreased TMIGD1 aggravates colitis and intestinal barrier dysfunction via the BANF1-NF-κB pathway in Crohn's disease., PMID:37542259
Important roles of Hif1a in maternal or adult BPA exposure induced pancreatic injuries., PMID:37460698
A Novel HOXA10-Associated 5-Gene-Based Prognostic Signature for Stratification of Short-term Survivors of Pancreatic Ductal Adenocarcinoma., PMID:37432996
A De Novo Sequence Variant in Barrier-to-Autointegration Factor Is Associated with Dominant Motor Neuronopathy., PMID:36980188
Analysis of a rare progeria variant of Barrier-to-autointegration factor in Drosophila connects centromere function to tissue homeostasis., PMID:36842139
Identification of Parkinson's disease-associated chromatin regulators., PMID:36813848
Barrier-to-autointegration factor 1 promotes gammaherpesvirus reactivation from latency., PMID:36746947
The Nuclear Envelope in Ageing and Progeria., PMID:36600129
Hepatitis B Virus X Protein Inhibits the Expression of Barrier To Autointegration factor1 via Upregulating miR-203 Expression in Hepatic Cells., PMID:36519846
The Conformation of the Intrinsically Disordered N-Terminal Region of Barrier-to-Autointegration Factor (BAF) is Regulated by pH and Phosphorylation., PMID:36402223
CRISPRi screening reveals regulators of tau pathology shared between exosomal and vesicle-free tau., PMID:36316035
The role of inner nuclear membrane proteins in tumourigenesis and as potential targets for cancer therapy., PMID:36205821
Identification of a Gene Panel Predictive of Triple-Negative Breast Cancer Response to Neoadjuvant Chemotherapy Employing Transcriptomic and Functional Validation., PMID:36142814
Disruption of nuclear envelope integrity as a possible initiating event in tauopathies., PMID:36001963
Mechanisms of A-Type Lamin Targeting to Nuclear Ruptures Are Disrupted in LMNA- and BANF1-Associated Progerias., PMID:35269487
Emerin self-assembly and nucleoskeletal coupling regulate nuclear envelope mechanics against stress., PMID:35178558
The Impact of Rare Human Variants on Barrier-To-Auto-Integration Factor 1 (Banf1) Structure and Function., PMID:34820387
Generalized lipoatrophy syndromes., PMID:34562560
β-actin dependent chromatin remodeling mediates compartment level changes in 3D genome architecture., PMID:34475390
ARID1A regulates R-loop associated DNA replication stress., PMID:33826602
Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners., PMID:33744941
Barrier-to-autointegration factor: a first responder for repair of nuclear ruptures., PMID:33678126
Barrier-to-autointegration-factor (Banf1) modulates DNA double-strand break repair pathway choice via regulation of DNA-dependent kinase (DNA-PK) activity., PMID:33660778
The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies., PMID:33361335
SWI/SNF Alterations in Squamous Bladder Cancers., PMID:33227989
The Vaccinia Virus B12 Pseudokinase Represses Viral Replication via Interaction with the Cellular Kinase VRK1 and Activation of the Antiviral Effector BAF., PMID:33177193
The role of the SWI/SNF chromatin remodelling complex in the response to DNA double strand breaks., PMID:33087260
Development of a structure-analysis pipeline using multiple-solvent crystal structures of barrier-to-autointegration factor., PMID:33021502
Diverse cellular functions of barrier-to-autointegration factor and its roles in disease., PMID:32817163
BAF restricts cGAS on nuclear DNA to prevent innate immune activation., PMID:32792394
An additional case of Néstor-Guillermo progeria syndrome diagnosed in early childhood., PMID:32783369
Downregulation of VRK1 reduces the expression of BANF1 and suppresses the proliferative and migratory activity of esophageal cancer cells., PMID:32724356
DNA unchained: two assays to discover and study inhibitors of the DNA clustering function of barrier-to-autointegration factor., PMID:32704141
The variability of SMARCA4-related Coffin-Siris syndrome: Do nonsense candidate variants add to milder phenotypes?, PMID:32686290
Structure of the yeast Swi/Snf complex in a nucleosome free state., PMID:32636384
For research use only. Not for human or drug use.
