FHC19123
Human
Mouse
IgG2a, kappa
Monoclonal
APC
FCM, WB
INSR, IR, CD220, Insulin receptor
0.5 mg/ml
Please contact with the lab for this information.
Liquid
0.01M PBS, pH 7.4, 0.2% BSA, 0.05% Proclin 300.
Store at 4°C for 12 months. Protect from light. Do not freeze.
SAA0334
For research use only.
Decline in exogenous gene expression in primate brain following intravenous administration is due to plasmid degradation., PMID:16779704
N-linked glycans of the human insulin receptor and their distribution over the crystal structure., PMID:17957771
Antibody-mediated targeting of siRNA via the human insulin receptor using avidin-biotin technology., PMID:19093871
A modified protocol for efficient DNA encapsulation into pegylated immunoliposomes (PILs)., PMID:19545595
Selective targeting of a TNFR decoy receptor pharmaceutical to the primate brain as a receptor-specific IgG fusion protein., PMID:20100527
Biologic TNFα-inhibitors that cross the human blood-brain barrier., PMID:21327054
Altered expression of insulin receptor isoforms in breast cancer., PMID:22046260
Reengineering biopharmaceuticals for targeted delivery across the blood-brain barrier., PMID:22230573
Correlation between gene expression of IGF-1R pathway markers and cetuximab benefit in metastatic colorectal cancer., PMID:22294722
Circulating insulin-like growth factors may contribute substantially to insulin receptor isoform A and insulin receptor isoform B signalling., PMID:22982059
Pharmacokinetics and brain uptake in the rhesus monkey of a fusion protein of arylsulfatase a and a monoclonal antibody against the human insulin receptor., PMID:23192358
Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer., PMID:24338270
Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity., PMID:24533136
Insulin and metabolic stress stimulate multisite serine/threonine phosphorylation of insulin receptor substrate 1 and inhibit tyrosine phosphorylation., PMID:24652289
Insulin receptor antibody-iduronate 2-sulfatase fusion protein: pharmacokinetics, anti-drug antibody, and safety pharmacology in Rhesus monkeys., PMID:24889100
Successful pregnancy outcomes in a patient with type A insulin resistance syndrome., PMID:25472847
Insulin family polymorphisms in pregnancies complicated by small for gestational age infants., PMID:26089371
Intrinsic Resistance to Cixutumumab Is Conferred by Distinct Isoforms of the Insulin Receptor., PMID:26263910
Insulin treatment promotes tyrosine phosphorylation of PKR and inhibits polyIC induced PKR threonine phosphorylation., PMID:26321373
A Novel Allosteric Insulin Receptor-Activating Antibody Reduces Hyperglycemia without Hypoglycemia in Diabetic Cynomolgus Monkeys., PMID:26578267
Type B insulin resistance syndrome., PMID:27254267
Systematic Population Screening, Using Biomarkers and Genetic Testing, Identifies 2.5% of the U.K. Pediatric Diabetes Population With Monogenic Diabetes., PMID:27271189
Re-engineering therapeutic antibodies for Alzheimer's disease as blood-brain barrier penetrating bi-specific antibodies., PMID:27572805
Ridaforolimus (MK-8669) synergizes with Dalotuzumab (MK-0646) in hormone-sensitive breast cancer., PMID:27765027
Diabetic Ketoacidosis Without Diabetes., PMID:27636019
Brain and Organ Uptake in the Rhesus Monkey in Vivo of Recombinant Iduronidase Compared to an Insulin Receptor Antibody-Iduronidase Fusion Protein., PMID:28279069
Detection of Islet Cell Immune Reactivity with Low Glycemic Index Foods: Is This a Concern for Type 1 Diabetes?, PMID:28819632
Delivery of Biologics Across the Blood-Brain Barrier with Molecular Trojan Horse Technology., PMID:29067674
Evaluation of anti-insulin receptor antibodies as potential novel therapies for human insulin receptoropathy using cell culture models., PMID:29700562
Combined Immunosuppressive Therapy Induces Remission in Patients With Severe Type B Insulin Resistance: A Prospective Cohort Study., PMID:30201849
Oncofoetal insulin receptor isoform A marks the tumour endothelium; an underestimated pathway during tumour angiogenesis and angiostatic treatment., PMID:30559346
Glucose-Sensitive Myokine/Cardiokine MG53 Regulates Systemic Insulin Response and Metabolic Homeostasis., PMID:30586741
The expression of the insulin receptor in gastric cancer correlates with the HER2 status and may have putative therapeutic implications., PMID:30989432
Rare causes of hypoglycemia in adults., PMID:32409005
M2‑like tumour‑associated macrophage‑secreted IGF promotes thyroid cancer stemness and metastasis by activating the PI3K/AKT/mTOR pathway., PMID:34184083
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For research use only. Not for human or drug use.
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