Catalog No.
YHA47601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gly24-Pro64
Predicted molecular weight
31.17 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15263
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
SAP1, Beta-defensin 4A, DEFB4, hBD-2, BD-2, Skin-antimicrobial peptide 1, Beta-defensin 2, Defensin, beta 2, DEFB2, DEFB4A, DEFB102
Comparison of salivary statherin and beta-defensin-2 levels, oral health behaviors, and demographic factors in children with and without early childhood caries., PMID:40450305
Human beta defensin-2 protects the epithelial barrier during methicillin-resistant Staphylococcus aureus infection in chronic rhinosinusitis with nasal polyps., PMID:40415954
GLIO-Select: Machine Learning-Based Feature Selection and Weighting of Tissue and Serum Proteomic and Metabolomic Data Uncovers Sex Differences in Glioblastoma., PMID:40362575
HPV16 E7 inhibits HBD2 expression by down-regulation of ASK1-p38 MAPK pathway in cervical cancer., PMID:40253372
Isolation of dihydroagarofuran sesquiterpene from the fruits of Tripterygium hypoglaucum and evaluation of their anti-inflammatory activity., PMID:40118309
The Role of Beta-Defensin 2 in Preventing Preterm Birth with Chorioamnionitis: Insights into Inflammatory Responses and Epithelial Barrier Protection., PMID:40076749
Distinct anti-microbial peptides expression patterns and microbiome profiles in skin of Tunisian endemic Pemphigus foliaceus patients., PMID:40009223
Associations between plasma proteins and psychological wellbeing: evidence from over 20 years of the English Longitudinal Study of Ageing., PMID:39974132
Exploring the Interaction of RBD with Human β Defensin Type 2 Point Mutants: Insights from Molecular Dynamics Simulations., PMID:39929747
Possible immunomodulatory role of Filifactor alocis through beta-defensin 2 in gingival keratinocytes., PMID:39592494
Synergistic role of Mycobacterium indicus pranii and human beta Defensin-2 as adjunctive therapy against Mycobacterium tuberculosis., PMID:39442483
Human β-defensin 2: a connection between infections and allergic skin diseases., PMID:39324351
Correlation and Clinical Significance of HBD-2 and CXCL-1/2 Levels at Skin Lesions with Psoriasis Vulgaris Severity., PMID:39301953
Human Beta Defensin-2 mRNA and Proteasome Subunit β Type 8 mRNA Analysis, Useful in Differentiating Skin Biopsies from Atopic Dermatitis and Psoriasis Vulgaris Patients., PMID:39273140
Acute salivary antimicrobial peptide secretion response to different exercise intensities and durations., PMID:39155711
Effects of Ellagic Acid on Vaginal Innate Immune Mediators and HPV16 Infection In Vitro., PMID:39125034
Spesolimab Reduces Inflammation in Generalized Pustular Psoriasis: Molecular Characterization of Flare Treatment in EFFISAYIL 1., PMID:39004117
Identification of human host factors required for beta-defensin-2 expression in intestinal epithelial cells upon a bacterial challenge., PMID:38965312
Gut Inflammation Markers, Diet, and Risk of Islet Autoimmunity in Finnish Children - A Nested Case-Control Study., PMID:38795745
Association of intestinal inflammation and permeability markers with clinical manifestations of Parkinson's disease., PMID:38554664
Development of an immune-related diagnostic predictive model for oral lichen planus., PMID:38489725
Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis., PMID:38433843
Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis., PMID:38414093
Bacillus subtilis Induces Human Beta Defensin-2 Through its Lipoproteins in Human Intestinal Epithelial Cells., PMID:38376819
Innate Immunity Activation in Newly Diagnosed Ileocolonic Crohn's Disease: A Cohort Study., PMID:38319717
Molecular Dynamics Simulations on Spike Protein Mutants Binding with Human β Defensin Type 2., PMID:38189674
β-defensin 2 protects against Escherichia coli-induced acute urinary tract infection by downregulating β-catenin., PMID:38070628
Multi-omics segregate different transcriptomic impacts of anti-IL-17A blockade on type 17 T-cells and regulatory immune cells in psoriasis skin., PMID:37781383
Human α-Defensin 51-9 and Human β-Defensin 2 Improve Metabolic Parameters and Gut Barrier Function in Mice Fed a Western-Style Diet., PMID:37762180
IκBζ is an essential mediator of immunity to oropharyngeal candidiasis., PMID:37725983
Establishment of Baseline Urinary Antimicrobial Peptide Levels by Age: A Prospective Observational Study., PMID:37708314
Cervicovaginal Microbial-Immune State and Group B Streptococcus Colonization in Pregnancy., PMID:37557898
Therapeutic modalities of human β defensin-2 with prospective significance in diabetic wound treatment., PMID:37253703
Elucidating the NB-UVB mechanism by comparing transcriptome alteration on the edge and center of psoriatic plaques., PMID:36928592
Antimicrobial peptide human β-defensin-2 improves in vitro cellular viability and reduces pro-inflammatory effects induced by enteroinvasive Escherichia coli in Caco-2 cells by inhibiting invasion and virulence factors' expression., PMID:36310877
Effects of Modified Sang ju-Yin Decoction Combined with IFNαlb Nebulization on IL-1β and HBD2 in Children with Asthmatic Bronchitis., PMID:35785143
Regulation of NFKBIZ gene promoter activity by STAT3, C/EBPβ, and STAT1., PMID:35537286
Human β-Defensin 2 (HBD-2) Displays Oncolytic Activity but Does Not Affect Tumour Cell Migration., PMID:35204765
Emerging Roles of Vitamin D-Induced Antimicrobial Peptides in Antiviral Innate Immunity., PMID:35057465
MIR337-3p Enhances Mycobacterial Pathogenicity Involving TLR4/MYD88 and STAT3 Signals, Impairing VDR Antimicrobial Response and Fast-Acting Immunity., PMID:34912331
Cervicovaginal levels of human beta defensins during bacterial vaginosis., PMID:34855866
Human β-Defensin 2 and Its Postulated Role in Modulation of the Immune Response., PMID:34831214
Inactivation of HIV-1 in Polarized Infant Tonsil Epithelial Cells by Human Beta-Defensins 2 and 3 Tagged with the Protein Transduction Domain of HIV-1 Tat., PMID:34696473
Bitter Taste Receptor T2R14 Modulates Gram-Positive Bacterial Internalization and Survival in Gingival Epithelial Cells., PMID:34576085
Human beta-defensins 2 and 4 are dysregulated in patients with coronavirus disease 19., PMID:34547411
Hybrid derivative of cathelicidin and human beta defensin-2 against Gram-positive bacteria: A novel approach for the treatment of bacterial keratitis., PMID:34526600
Impact of isoflavone genistein on psoriasis in in vivo and in vitro investigations., PMID:34521933
Human beta defensin levels and vaginal microbiome composition in post-menopausal women diagnosed with lichen sclerosus., PMID:34362937
Effect of Early Feeding on Intestinal Permeability and Inflammation Markers in Infants with Genetic Susceptibility to Type 1 Diabetes: A Randomized Clinical Trial., PMID:34293372
Serum Human β-Defensin 2 Is Increased in Angioedema Accompanying Chronic Spontaneous Urticaria., PMID:34139696
For research use only. Not for human or drug use.
