Catalog No.
YHA41901
Description
NPC1/Niemann-Pick C1 protein (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable).
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln23-Asp266
Predicted molecular weight
29.31 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15118
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NPC intracellular cholesterol transporter 1, Niemann-Pick C1 protein, NPC1, receptor for ebolavirus, receptor for ebolavirus
Wisteria floribunda agglutinin enhances Zaire ebolavirus entry through interactions at specific N-linked glycosylation sites on the virus glycoprotein complex., PMID:40476860
Discovery of novel diagnostic biomarkers of hepatocellular carcinoma associated with immune infiltration., PMID:40440122
Niemann Pick C1 mistargeting disrupts lysosomal cholesterol homeostasis contributing to neurodegeneration in a Batten disease model., PMID:40333988
Causal Associations Between Lipids, NPC1L1, and Liver Cancer Risk: Insights From Mendelian Randomization and Bioinformatics., PMID:40312834
Sex-dependent upregulation in oxylipins involved in inflammation resolution in the cerebellum of Niemann-Pick disease C1 mice., PMID:40306479
ApoE4 requires lipidation enhancement to resolve cellular lipid and protein abnormalities following NPC1 inhibition., PMID:40301465
Association between lipid-lowering drug targets and the risk of cystic kidney disease: a drug-target Mendelian randomization analysis., PMID:40289090
Npc1 gene mutation impairs multilineage differentiation potential of hepatic telocytes in murine models., PMID:40257496
Mapping Immunological, Host Receptor Binding Determinants, and Cathepsin Cleavage Site of EBOV Glycoprotein Utilizing the Qubevirus Platform., PMID:40256529
Evidence of Oxytosis/Ferroptosis in Niemann-Pick Disease Type C., PMID:40243519
Effects of opium on cholesterol metabolism in rats fed normal and high-fat/high-cholesterol diet., PMID:40230514
Causal Association Between Cholesterol-Lowering Drugs and Diabetic Microvascular Complications: A Drug-Target Mendelian Randomization Study., PMID:40225015
Mechanistic insights into arimoclomol mediated effects on lysosomal function in Niemann-pick type C disease., PMID:40215728
TPCs: FROM PLANT TO HUMAN., PMID:40197126
Uncovering the Causal Link Between Obesity-Associated Genes and Multiple Sclerosis: A Systematic Literature Review., PMID:40195065
Small-molecule activation of TFEB alleviates Niemann-Pick disease type C via promoting lysosomal exocytosis and biogenesis., PMID:40184172
Development of a neutralization assay and bioluminescent imaging mouse model for Dehong virus (DEHV) using a pseudovirus system., PMID:40172216
Identification of a Novel NPC1L1 Inhibitor from Danshen and Its Role in Nonalcoholic Fatty Liver Disease., PMID:40141435
Triglyceride-lowering effect of rice protein due to the regulation of fatty acid uptake and transport of triglyceride in rats fed normal/oil-enriched diets., PMID:40135185
Development of a prognostic risk model for colorectal cancer and association of the prognostic model with cancer stem cell and immune cell infiltration., PMID:40115909
Intracellular anionic substances cause tau liquid-liquid phase separation., PMID:40107109
Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks., PMID:40106905
Elevated Cerebrospinal Fluid Total Tau in Niemann-Pick Disease Type C1: Correlation With Clinical Severity and Response to Therapeutic Interventions., PMID:40064165
Ezetimibe alters micelle structure and reduces Niemann-Pick C1-like 1-mediated absorption of vitamins E and K1 in CaCo-2 cells., PMID:40054527
Expression of the Niemann-Pick C1-like 1 Protein in Gastric Cancer., PMID:40037881
Detecting the Difficult: An Intronic NPC1 Variant Hiding in Plain Sight., PMID:40026274
Prevalence of Neutralizing Antibodies to AAV2 and AAV9 in Individuals with Niemann-Pick Disease, Type C1., PMID:40014475
Cholesin mRNA Expression in Human Intestinal, Liver, and Adipose Tissues., PMID:40004948
Distinct pathways for the absorption and metabolism of β-carotene and zeaxanthin in the mouse intestine., PMID:39971162
Microbiota-derived 3-Methyl-L-histidine mediates the proatherogenic effect of high chicken protein diet., PMID:39949981
Associations of Lipid-Lowering Drugs With Blood Pressure and Fasting Glucose: A Mendelian Randomization Study., PMID:39902581
Cryo-EM structure of Sudan ebolavirus glycoprotein complexed with its human endosomal receptor NPC1., PMID:39894818
Altered lipid homeostasis and autophagy precipitate diffuse alveolar hemorrhage in murine lupus., PMID:39871963
Dual targeting PPARα and NPC1L1 metabolic vulnerabilities blocks tumorigenesis., PMID:39862918
Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway., PMID:39857778
Cholesterol mobilization regulates dendritic cell maturation and the immunogenic response to cancer., PMID:39838105
Decoding the blueprint of receptor binding by filoviruses through large-scale binding assays and machine learning., PMID:39818205
Clinical manifestations and molecular genetics of seven patients with Niemann-Pick type-C: a case series with a novel variant., PMID:39789920
The multiple facets of Rab proteins modulating the cellular distribution of cholesterol from the late endosomal compartment., PMID:39788156
NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression., PMID:39762312
Lipids, lipid-lowering drugs and the risk of herpes zoster: a Mendelian randomization study., PMID:39755897
An integrative approach to identifying NPC1 as a susceptibility gene for gestational diabetes mellitus., PMID:39746811
Multiple cell types support productive infection and dynamic translocation of infectious Ebola virus to the surface of human skin., PMID:39742475
Causal effects of circulating lipids and lipid-lowering drugs on the risk of atopic dermatitis: a mendelian randomization study., PMID:39718588
Dipyridamole Ameliorates Memory Impairment and Increases Hippocampal Calbindin Expression in Niemann Pick C1 Mice., PMID:39716810
NPC1 promotes the progression of hepatocellular carcinoma by mediating the accumulation of neutrophils into the tumor microenvironment., PMID:39707615
The inactivation of the Niemann Pick C1 cholesterol transporter restricts SARS-CoV-2 entry into host cells by decreasing ACE2 abundance at the plasma membrane., PMID:39707537
Instationary metabolic flux analysis reveals that NPC1 inhibition increases glycolysis and decreases mitochondrial metabolism in brain microvascular endothelial cells., PMID:39706535
Genetic correlation between genes targeted by lipid-lowering drugs and venous thromboembolism: A drug-target Mendelian randomization study., PMID:39705479
The Plasmodium falciparum NCR1 transporter is an antimalarial target that exports cholesterol from the parasite's plasma membrane., PMID:39693420
For research use only. Not for human or drug use.
