Catalog No.
YHA16901
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ala30-Ala326
Predicted molecular weight
34.33 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00602
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ficolin-alpha, FCNM, Ficolin-A, FCN1, Ficolin-1, Collagen/fibrinogen domain-containing protein 1, M-ficolin
Proteogenomic characterization of molecular and cellular targets for treatment-resistant subtypes in locally advanced cervical cancers., PMID:40087745
SARS-CoV-2 enhances complement-mediated endothelial injury via the suppression of membrane complement regulatory proteins., PMID:39945674
Activation of S1PR2 on macrophages and the hepatocyte S1PR2/RhoA/ROCK1/MLC2 pathway in vanishing bile duct syndrome., PMID:39854311
[Effect of FCN gene single nucleotide polymorphism on the susceptibility of pre-eclampsia in Han nationality pregnant women]., PMID:39581768
FPR1 signaling aberrantly regulates S100A8/A9 production by CD14+FCN1hi macrophages and aggravates pulmonary pathology in severe COVID-19., PMID:39402337
Unveiling ficolins: diagnostic and prognostic biomarkers linked to the Tumor Microenvironment in Lung Cancer., PMID:39390580
Multi-omics evaluation of the prognostic value and immune signature of FCN1 in pan-cancer and its relationship with proliferation and apoptosis in acute myeloid leukemia., PMID:39139822
Novel tumor-associated macrophage populations and subpopulations by single cell RNA sequencing., PMID:38347955
SPP1+ TAM subpopulations in tumor microenvironment promote intravasation and metastasis of head and neck squamous cell carcinoma., PMID:38052857
Bioinformatics analysis reveals the potential common genes and immune characteristics between atrial fibrillation and periodontitis., PMID:37971162
Integrated multiple-microarray analysis and mendelian randomization to identify novel targets involved in diabetic nephropathy., PMID:37492198
The Soluble Lectin Families as Novel Biomarkers for COVID-19 Pneumonia., PMID:37369511
Transcriptomic analysis reveals shared gene signatures and molecular mechanisms between obesity and periodontitis., PMID:37063877
Identification of FCN1 as a novel macrophage infiltration-associated biomarker for diagnosis of pediatric inflammatory bowel diseases., PMID:36932401
A large-scale plasma proteome Mendelian randomization study identifies novel causal plasma proteins related to primary biliary cholangitis., PMID:36825008
A novel necroptosis-related gene index for predicting prognosis and a cold tumor immune microenvironment in stomach adenocarcinoma., PMID:36389725
Integrated analysis of potential gene crosstalk between non-alcoholic fatty liver disease and diabetic nephropathy., PMID:36387855
Comprehensive Analysis of Prognostic Value and Immune Infiltration of Ficolin Family Members in Hepatocellular Carcinoma., PMID:35928441
A single-cell lung atlas of complement genes identifies the mesothelium and epithelium as prominent sources of extrahepatic complement proteins., PMID:35672453
Immunopathogenic overlap between COVID-19 and tuberculosis identified from transcriptomic meta-analysis and human macrophage infection., PMID:35634577
Analysis of Complement Gene Expression, Clinical Associations, and Biodistribution of Complement Proteins in the Synovium of Early Rheumatoid Arthritis Patients Reveals Unique Pathophysiologic Features., PMID:35500934
Prognostic Biomarker-Based Identification of Drugs for Managing the Treatment of Endometrial Cancer., PMID:34155607
COVID-19 and RA share an SPP1 myeloid pathway that drives PD-L1+ neutrophils and CD14+ monocytes., PMID:34143756
Expansion of Fcγ Receptor IIIa-Positive Macrophages, Ficolin 1-Positive Monocyte-Derived Dendritic Cells, and Plasmacytoid Dendritic Cells Associated With Severe Skin Disease in Systemic Sclerosis., PMID:34042322
Hepatitis B Virus Infection Among Leprosy Patients: A Case for Polymorphisms Compromising Activation of the Lectin Pathway and Complement Receptors., PMID:33643280
FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study., PMID:33600013
Association of ficolin-1 and ficolin-3 gene variation and pulmonary tuberculosis susceptibility in a Chinese population., PMID:33591573
Integrated bulk and single-cell RNA-sequencing identified disease-relevant monocytes and a gene network module underlying systemic sclerosis., PMID:33039247
Ficolin-1 and ficolin-3 polymorphisms and susceptibility to rheumatoid arthritis., PMID:32820945
Associations of ficolins and mannose-binding lectin with acute myeloid leukaemia in adults., PMID:32601370
Ficolin-1 gene (FCN1) -144 C/A polymorphism is associated with adverse outcome of severe pneumonia in the under-five Egyptian children: A multicenter study., PMID:32142211
Associations of Ficolins With Hematological Malignancies in Patients Receiving High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantations., PMID:32047495
Selected factors of the innate immunity in Polish patients suffering from pulmonary tuberculosis., PMID:32007302
Immunosuppression in Cows following Intramammary Infusion of Mycoplasma bovis., PMID:31843962
NCF2, MYO1F, S1PR4, and FCN1 as potential noninvasive diagnostic biomarkers in patients with obstructive coronary artery: A weighted gene co-expression network analysis., PMID:31245869
Identification of Candidate Genes and MicroRNAs for Acute Myocardial Infarction by Weighted Gene Coexpression Network Analysis., PMID:30886860
Two distinct colonic CD14+ subsets characterized by single-cell RNA profiling in Crohn's disease., PMID:30670762
Sickening or Healing the Heart? The Association of Ficolin-1 and Rheumatic Fever., PMID:30619357
Ficolin-1 is a promising therapeutic target for autoimmune diseases., PMID:30169661
Gene expression profiling of acute myeloid leukemia samples from adult patients with AML-M1 and -M2 through boutique microarrays, real-time PCR and droplet digital PCR., PMID:29286103
FCN1 (M-ficolin), which directly associates with immunoglobulin G1, is a molecular target of intravenous immunoglobulin therapy for Kawasaki disease., PMID:28900133
Polymorphism in ficolin-1 (FCN1) gene is associated with an earlier onset of type 1 diabetes mellitus in children and adolescents from northeast Brazil., PMID:27994205
Components of the lectin pathway of complement activation in paediatric patients of intensive care units., PMID:26850322
Ficolin Gene Polymorphisms in Systemic Lupus Erythematosus and Rheumatoid Arthritis., PMID:26464189
The pattern recognition molecule ficolin-1 exhibits differential binding to lymphocyte subsets, providing a novel link between innate and adaptive immunity., PMID:24161415
Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients., PMID:23944633
Identification of biomarkers of response to IFNg during endotoxin tolerance: application to septic shock., PMID:23874546
Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1., PMID:23383108
Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin., PMID:23209787
Susceptibility to leprosy is associated with M-ficolin polymorphisms., PMID:22941510
For research use only. Not for human or drug use.
