Catalog No.
YHA16401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Ser24-Pro134
Predicted molecular weight
14.55 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00585
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
C-C motif chemokine 21, SCYA21, Small-inducible cytokine A21, CCL21, Beta-chemokine exodus-2, 6Ckine, Secondary lymphoid-tissue chemokine, SLC
Increased Fascin1 and Pak1 Expressions Enhance Age-Associated B-Cell Actin Cytoskeleton Remodeling and Motility., PMID:40500987
Bulk and single-cell RNA-sequencing analyses revealed potential key genes and the role of CCL19/CCL21-CCR7 axis in hidradenitis suppurativa., PMID:40455785
CXCL12+ fibroblastic reticular cells in lymph nodes facilitate immune tolerance by regulating T cell-mediated alloimmunity., PMID:40309773
Differential biomarker expression of blood and lymphatic vasculature in multi-organ-chips., PMID:40281034
An injectable oncolytic hydrogel platform for in situ dendritic cell vaccination to boost antitumor immunity., PMID:40243662
Spatially resolved atlas of breast cancer uncovers intercellular machinery of venular niche governing lymphocyte extravasation., PMID:40199901
Spatial relationships and interactions of immune cell niches are linked to the pathologic response of muscle-invasive bladder cancer to neoadjuvant therapy., PMID:40148849
Involvement of naïve T cells in the pathogenesis of osimertinib-induced pneumonitis., PMID:40148432
DNA methylation-predicted plasma protein levels and breast cancer risk., PMID:40140843
B cells and energy metabolism in HER2-positive DCIS: insights into breast cancer progression from spatial-omics analyses., PMID:40119362
A novel peptide targeting CCR7 inhibits tumor cell lymph node metastasis., PMID:40105966
Orbital Clinicopathological Differences in Thyroid Eye Disease: An Analysis of Cytokines With Histopathological and Clinical Correlation., PMID:40100205
Plasmin reduces human T cell arrest on endothelial-like cells by cleaving bound CCL21 from the cell surface., PMID:40010560
Transient Lymphatic Remodeling Follows Sub-Ablative High-Frequency Irreversible Electroporation Therapy in a 4T1 Murine Model., PMID:39998766
Gene expression regulation and polyadenylation in ulcerative colitis via long-chain RNA sequencing., PMID:39955510
CCR7 in esophageal squamous cell carcinoma: an identification from single-cell and bulk transcriptome sequencing., PMID:39953263
Efficacy of Dapagliflozin and Telmisartan Combination Therapy in Reducing Albuminuria and Inflammatory Markers in Diabetic Nephropathy: A Prospective Observational Study., PMID:39949102
CCL21-CCR7 blockade prevents neuroinflammation and degeneration in Parkinson's disease models., PMID:39894839
Transcript Changes of Placental Tissue in Gestational Diabetes Mellitus Based on Transcriptome Sequencing., PMID:39882105
Identification of Immune Infiltration-Associated CC Motif Chemokine Ligands as Biomarkers and Targets for Colorectal Cancer Prevention and Immunotherapy., PMID:39859340
Painful diabetic neuropathy is associated with accelerated epigenetic aging., PMID:39847262
Optimized BCMA/CS1 bispecific TRuC-T cells secreting IL-7 and CCL21 robustly control multiple myeloma., PMID:39776916
Chemotherapy-induced cellular senescence promotes stemness of aggressive B-cell non-Hodgkin's lymphoma via CCR7/ARHGAP18/IKBα signaling activation., PMID:39773566
The Chemokine System as a Key Regulator of Pulmonary Fibrosis: Converging Pathways in Human Idiopathic Pulmonary Fibrosis (IPF) and the Bleomycin-Induced Lung Fibrosis Model in Mice., PMID:39768150
Urinary Immune Complexes Reflect Renal Pathology in Lupus Nephritis., PMID:39767148
Lenalidomide regulates the CCL21/CCR7/ERK1/2 axis to inhibit migration and proliferation in diffuse large B-cell lymphoma., PMID:39735670
Inflammation switches the chemoattractant requirements for naive lymphocyte entry into lymph nodes., PMID:39708807
Direct and indirect RANK and CD40 signaling regulate the maintenance of thymic epithelial cell frequency and properties in the adult thymus., PMID:39676866
Injectable microgels containing genetically engineered bacteria for colon cancer therapy through programmed Chemokine expression., PMID:39624050
Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement., PMID:39623381
Accelerated senescence exacerbates α-synucleinopathy in senescence-accelerated prone 8 mice via persistent neuroinflammation., PMID:39586378
Characteristics of a CCL21 Gene-Modified Dendritic Cell Vaccine Utilized for a Clinical Trial in Non-Small Cell Lung Cancer., PMID:39559833
A causal association between chemokines and the risk of lung cancer: a univariate and multivariate mendelian randomization study., PMID:39516747
Immunomodulation of human T cells by microbubble-mediated focused ultrasound., PMID:39502696
Ellagic acid ameliorates alcohol-induced cognitive and social dysfunction through the gut microbiota-mediated CCL21-CCR7 axis., PMID:39449276
Enhancing Th17 cells drainage through meningeal lymphatic vessels alleviate neuroinflammation after subarachnoid hemorrhage., PMID:39428510
On-chip human lymph node stromal network for evaluating dendritic cell and T-cell trafficking., PMID:39332444
Acute kidney injury results in long-term alterations of kidney lymphatics in mice., PMID:39323387
Skewed epithelial cell differentiation and premature aging of the thymus in the absence of vitamin D signaling., PMID:39321290
Mutant mice lacking alternatively spliced p53 isoforms unveil Ackr4 as a male-specific prognostic factor in Myc-driven B-cell lymphomas., PMID:39298333
C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via β2-Integrins., PMID:39273598
Integrating chemokines and machine learning algorithms for diagnosis and bleeding assessment in primary immune thrombocytopenia: A prospective cohort study., PMID:39253817
Mesenchymal stromal cells restrain the Th17 cell response via L-amino-acid oxidase within lymph nodes., PMID:39251573
Characterization of pre- and on-treatment soluble immune mediators and the tumor microenvironment in NSCLC patients receiving PD-1/L1 inhibitor monotherapy., PMID:39235457
Lithium-induced apoptotic cell death is not accompanied by a noticeable inflammatory response in the kidney., PMID:39234304
High-dose radiation-induced immunogenic cell death of bladder cancer cells leads to dendritic cell activation., PMID:39231199
Differences in T cell-associated serum markers between ischemic cardiomyopathy and dilated cardiomyopathy., PMID:39144301
Comprehensive Analysis and In Vitro Verification of Endothelial-Mesenchymal Transition-Related Genes in Moyamoya Disease., PMID:39134827
ILC2-derived LIF licences progress from tissue to systemic immunity., PMID:39112698
Clonal haematopoiesis is associated with major adverse cardiovascular events in patients with hypertrophic cardiomyopathy., PMID:39091134
For research use only. Not for human or drug use.
