Catalog No.
YHA16301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp25-His256
Predicted molecular weight
53.98 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00584
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ribonuclease T2, Ribonuclease 6, RNASET2, RNASE6PL,RNASET
The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners., PMID:40389981
Glycosylation Regulation by TMEM230 in Aging and Autoimmunity., PMID:40141059
A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer., PMID:39930075
RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol-Triggered MET Activation., PMID:39903758
RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells., PMID:39853307
RNase T2 restricts TLR13-mediated autoinflammation in vivo., PMID:39853306
Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis., PMID:39741066
Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis., PMID:39500942
Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study., PMID:39468243
Identifying genetic variants associated with chromatin looping and genome function., PMID:39289357
Exploring the role of RNASET2 in the immune response of black soldier fly larvae., PMID:39190478
PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses., PMID:39035989
Long-term culture of patient-derived mammary organoids in non-biogenic electrospun scaffolds for identifying metalloprotein and motor protein activities in aging and senescence., PMID:38960479
Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity., PMID:38960478
Transmembrane protein TMEM230, regulator of metalloproteins and motor proteins in gliomas and gliosis., PMID:38960477
Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model., PMID:38753517
Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma., PMID:38612777
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma., PMID:38576019
Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma., PMID:38431116
Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis., PMID:38424269
Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma., PMID:37679715
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis., PMID:37633478
HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma., PMID:36728187
Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion., PMID:36466822
A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease., PMID:36180758
Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms., PMID:36054934
Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis., PMID:36012339
Proteogenomic, Epigenetic, and Clinical Implications of Recurrent Aberrant Splice Variants in Clear Cell Renal Cell Carcinoma., PMID:35718636
AIF-1 and RNASET2 are involved in the inflammatory response in the Mediterranean mussel Mytilus galloprovincialis following Vibrio infection., PMID:35697269
Biomarkers of connective tissue disease-associated interstitial lung disease in bronchoalveolar lavage fluid: A label-free mass spectrometry-based relative quantification study., PMID:35334492
Genome-wide identification and characterization of legume T2 Ribonuclease gene family and analysis of GmaRNS9, a soybean T2 Ribonuclease gene, function in nodulation., PMID:34881158
A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia., PMID:34409659
Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway., PMID:34299186
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study., PMID:34291312
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer., PMID:33767133
Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer., PMID:33626918
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression., PMID:33577922
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?, PMID:33199448
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation., PMID:32647340
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma., PMID:32528897
Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages., PMID:32468025
Expression and purification of the human tumor suppressor protein RNASET2 in CHO-S cells., PMID:32450138
Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia., PMID:32295832
Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2., PMID:32294405
The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy., PMID:32212285
PTPN11 mutations in canine and human disseminated histiocytic sarcoma., PMID:32212266
Antimicrobial Role of RNASET2 Protein During Innate Immune Response in the Medicinal Leech Hirudo verbana., PMID:32210967
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection., PMID:32197460
Recombinant HvRNASET2 protein induces marked connective tissue remodelling in the invertebrate model Hirudo verbana., PMID:32043208
Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding., PMID:31909602
For research use only. Not for human or drug use.
