Catalog No.
YHA16301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp25-His256
Predicted molecular weight
53.98 kDa
Nature
Recombinant
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00584
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Ribonuclease T2, Ribonuclease 6, RNASET2, RNASE6PL,RNASET
Note
For research use only.
Insights into Structural and Dynamical Changes Experienced by Human RNase 6 upon Ligand Binding., PMID:31909602
Recombinant HvRNASET2 protein induces marked connective tissue remodelling in the invertebrate model Hirudo verbana., PMID:32043208
Overexpression of Murine Rnaset2 in a Colon Syngeneic Mouse Carcinoma Model Leads to Rebalance of Intra-Tumor M1/M2 Macrophage Ratio, Activation of T Cells, Delayed Tumor Growth, and Rejection., PMID:32197460
Antimicrobial Role of RNASET2 Protein During Innate Immune Response in the Medicinal Leech Hirudo verbana., PMID:32210967
PTPN11 mutations in canine and human disseminated histiocytic sarcoma., PMID:32212266
The failure of microglia to digest developmental apoptotic cells contributes to the pathology of RNASET2-deficient leukoencephalopathy., PMID:32212285
Immune Sensing of Synthetic, Bacterial, and Protozoan RNA by Toll-like Receptor 8 Requires Coordinated Processing by RNase T2 and RNase 2., PMID:32294405
Zebrafish disease model of human RNASET2-deficient cystic leukoencephalopathy displays abnormalities in early microglia., PMID:32295832
Expression and purification of the human tumor suppressor protein RNASET2 in CHO-S cells., PMID:32450138
Ribonuclease T2 from Aspergillus fumigatus promotes T helper type 2 responses through M2 polarization of macrophages., PMID:32468025
Expression, Location, Clinical Implication, and Bioinformatics Analysis of RNASET2 in Gastric Adenocarcinoma., PMID:32528897
Increased S1P induces S1PR2 internalization to blunt the sensitivity of colorectal cancer to 5-fluorouracil via promoting intracellular uracil generation., PMID:32647340
Heterogeneity of PNPT1 neuroimaging: mitochondriopathy, interferonopathy or both?, PMID:33199448
Atxn2-CAG100-KnockIn mouse spinal cord shows progressive TDP43 pathology associated with cholesterol biosynthesis suppression., PMID:33577922
Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer., PMID:33626918
FBXO6-mediated RNASET2 ubiquitination and degradation governs the development of ovarian cancer., PMID:33767133
Characteristics of children diagnosed with type 1 diabetes before vs after 6 years of age in the TEDDY cohort study., PMID:34291312
Hypoxia Enhances the Expression of RNASET2 in Human Monocyte-Derived Dendritic Cells: Role of PI3K/AKT Pathway., PMID:34299186
A new hemizygous missense mutation, c.454T＞C (p.S152P), in AKAP4 gene is associated with asthenozoospermia., PMID:34409659
Genome-wide identification and characterization of legume T2 Ribonuclease gene family and analysis of GmaRNS9, a soybean T2 Ribonuclease gene, function in nodulation., PMID:34881158
Biomarkers of connective tissue disease-associated interstitial lung disease in bronchoalveolar lavage fluid: A label-free mass spectrometry-based relative quantification study., PMID:35334492
AIF-1 and RNASET2 are involved in the inflammatory response in the Mediterranean mussel Mytilus galloprovincialis following Vibrio infection., PMID:35697269
Proteogenomic, Epigenetic, and Clinical Implications of Recurrent Aberrant Splice Variants in Clear Cell Renal Cell Carcinoma., PMID:35718636
Human RNASET2: A Highly Pleiotropic and Evolutionary Conserved Tumor Suppressor Gene Involved in the Control of Ovarian Cancer Pathogenesis., PMID:36012339
Myelin oligodendrocyte glycoprotein-associated disease is associated with BANK1, RNASET2 and TNIP1 polymorphisms., PMID:36054934
A potential role of human RNASET2 overexpression in the pathogenesis of Graves' disease., PMID:36180758
Diagnostic and therapeutic potential of RNASET2 in Crohn's disease: Disease-risk polymorphism modulates allelic-imbalance in expression and circulating protein levels and recombinant-RNASET2 attenuates pro-inflammatory cytokine secretion., PMID:36466822
HIF2α-induced upregulation of RNASET2 promotes triglyceride synthesis and enhances cell migration in clear cell renal cell carcinoma., PMID:36728187
Musashi-2 binds with Fbxo6 to induce Rnaset2 ubiquitination and chemokine signaling pathway during vascular smooth muscle cell phenotypic switch in atherosclerosis., PMID:37633478
Systematic analysis of RNASET2 gene as a potential prognostic and immunological biomarker in clear cell renal cell carcinoma., PMID:37679715
Dynamic relationship among extracellular matrix and body wall cells in Hirudo verbana morphogenesis., PMID:38424269
Pathogenic Roles for RNASET2 in Clear Cell Renal Cell Carcinoma., PMID:38431116
Systematic proteome-wide Mendelian randomization using the human plasma proteome to identify therapeutic targets for lung adenocarcinoma., PMID:38576019
Transmembrane Protein TMEM230, Regulator of Glial Cell Vascular Mimicry and Endothelial Cell Angiogenesis in High-Grade Heterogeneous Infiltrating Gliomas and Glioblastoma., PMID:38612777
Macrophage transplantation rescues RNASET2-deficient leukodystrophy by replacing deficient microglia in a zebrafish model., PMID:38753517
Transmembrane protein TMEM230, regulator of metalloproteins and motor proteins in gliomas and gliosis., PMID:38960477
Single-cell transcriptomic analysis to identify endomembrane regulation of metalloproteins and motor proteins in autoimmunity., PMID:38960478
Long-term culture of patient-derived mammary organoids in non-biogenic electrospun scaffolds for identifying metalloprotein and motor protein activities in aging and senescence., PMID:38960479
PTGES2 and RNASET2 identified as novel potential biomarkers and therapeutic targets for basal cell carcinoma: insights from proteome-wide mendelian randomization, colocalization, and MR-PheWAS analyses., PMID:39035989
Exploring the role of RNASET2 in the immune response of black soldier fly larvae., PMID:39190478
Identifying genetic variants associated with chromatin looping and genome function., PMID:39289357
Druggable targets for Parkinson's disease: transcriptomics based Mendelian randomization study., PMID:39468243
Regulation of neutrophil associated RNASET2 expression in rheumatoid arthritis., PMID:39500942
Association Between Autoimmune Thyroid disease and Oral Lichen Planus: A Multi-Omic Genetic Analysis., PMID:39741066
RNase T2 restricts TLR13-mediated autoinflammation in vivo., PMID:39853306
RNase T2 deficiency promotes TLR13-dependent replenishment of tissue-protective Kupffer cells., PMID:39853307
RNASET2 Deficiency Induces Hepatocellular Carcinoma Metastasis through Cholesterol-Triggered MET Activation., PMID:39903758
A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer., PMID:39930075
Glycosylation Regulation by TMEM230 in Aging and Autoimmunity., PMID:40141059
The human RNASET2 alarmin-like molecule differentially affects prostate cancer cells behavior in both cell autonomous and non-cell autonomous manners., PMID:40389981
For research use only. Not for human or drug use.
