Catalog No.
YHA09501
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Val220-Thr468
Predicted molecular weight
28.82 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00330
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
E3-binding protein, PDX1, Pyruvate dehydrogenase protein X component, mitochondrial, E3BP, PDHX, proX, Dihydrolipoamide dehydrogenase-binding protein of pyruvate dehydrogenase complex, Lipoyl-containing pyruvate dehydrogenase complex component X
Bioinformatics-led identification of pathophysiological hallmark genes in diabesotension via graph clustering method., PMID:40491693
Novel Synonymous and Deep Intronic Variants Causing Primary and Secondary Pyruvate Dehydrogenase Complex Deficiency., PMID:40225937
Co-exposure to ammonia and lipopolysaccharide-induced impaired energy metabolism via the miR-1599/HK2 axis and triggered autophagy, ER stress, and apoptosis in chicken cardiomyocytes., PMID:40043670
Cardiac ATP production and contractility are favorably regulated by short-term S100A9 blockade after myocardial infarction., PMID:39870300
Oridonin inhibits SGIV infection by regulating glycolipid metabolism and inflammatory response., PMID:39848352
An integrated multi-omics approach allowed ultra-rapid diagnosis of a deep intronic pathogenic variant in PDHX and precision treatment in a neonate critically ill with lactic acidosis., PMID:39413893
PDHX acetylation facilitates tumor progression by disrupting PDC assembly and activating lactylation-mediated gene expression., PMID:39311688
Phenylbutyrate and Dichloroacetate Enhance the Liquid-Stored Boar Sperm Quality via PDK1 and PDK3., PMID:38069413
Gastric cancer metastasis-related NT5DC2 indicates unfavorable prognosis of patients., PMID:37800836
Genetic architecture of acute hyperthermia resistance in juvenile rainbow trout (Oncorhynchus mykiss) and genetic correlations with production traits., PMID:37308823
Cuproptosis-related gene PDHX and heat stress-related HSPD1 as potential key drivers associated with cell stemness, aberrant metabolism and immunosuppression in esophageal carcinoma., PMID:36889194
ERN1 dependent impact of glutamine and glucose deprivations on the pyruvate dehydrogenase genes expression in glioma cells., PMID:36270342
Polystyrene microplastics-induced cardiotoxicity in chickens via the ROS-driven NF-κB-NLRP3-GSDMD and AMPK-PGC-1α axes., PMID:35714743
Singapore Grouper Iridovirus Induces Glucose Metabolism in Infected Cells by Activation of Mammalian Target of Rapamycin Signaling., PMID:35432224
The Mitochondrial Ca2+ import complex is altered in ADPKD., PMID:34823104
Downregulation of miR-181b-5p Inhibits the Viability, Migration, and Glycolysis of Gallbladder Cancer by Upregulating PDHX Under Hypoxia., PMID:34485121
Identification of PDHX as a metabolic target for esophageal squamous cell carcinoma., PMID:33964039
Energy metabolism disorder mediated ammonia gas-induced autophagy via AMPK/mTOR/ULK1-Beclin1 pathway in chicken livers., PMID:33853017
Pyruvate dehydrogenase complex deficiency: updating the clinical, metabolic and mutational landscapes in a cohort of Portuguese patients., PMID:33092611
Hepatic proteome analysis reveals altered mitochondrial metabolism and suppressed acyl-CoA synthetase-1 in colon-26 tumor-induced cachexia., PMID:32146873
miR-26a is Involved in Glycometabolism and Affects Boar Sperm Viability by Targeting PDHX., PMID:31936222
Impact of short- and long-term electrically induced muscle exercise on gene signaling pathways, gene expression, and PGC1a methylation in men with spinal cord injury., PMID:31869286
H2-Based Electrochemical Biosensor with Pd Nanowires@ZIF-67 Molecular Sieve Bilayered Sensing Interface for Immunoassay., PMID:31436433
Tumor-associated antigens identified early in mouse mammary tumor development can be effective vaccine targets., PMID:31126858
A patient with homozygous nonsense variants in two Leigh syndrome disease genes: Distinguishing a dual diagnosis from a hypomorphic protein-truncating variant., PMID:30981218
Proton conductivity of glycosaminoglycans., PMID:30849116
Electronic control of H+ current in a bioprotonic device with carbon nanotube porins., PMID:30794578
The HGF-MET axis coordinates liver cancer metabolism and autophagy for chemotherapeutic resistance., PMID:30786811
Two-Channel Bioprotonic Photodetector., PMID:35016296
Suppression of PDHX by microRNA-27b deregulates cell metabolism and promotes growth in breast cancer., PMID:30012170
Alleviation Mechanisms of Selenium on Cadmium-Spiked in Chicken Ovarian Tissue: Perspectives from Autophagy and Energy Metabolism., PMID:29679350
Remembering MUDPILES: A Case of Unexplained Metabolic Acidosis., PMID:28487291
Complex genetic findings in a female patient with pyruvate dehydrogenase complex deficiency: Null mutations in the PDHX gene associated with unusual expression of the testis-specific PDHA2 gene in her somatic cells., PMID:27343776
Mendeliome sequencing enables differential diagnosis and treatment of neonatal lactic acidosis., PMID:27317552
Anti-apoptotic and Beneficial Metabolic Activities of Resveratrol in Type II Gaucher Disease., PMID:26027833
The overexpression and nuclear translocation of Trx-1 during hypoxia confers on HepG2 cells resistance to DDP, and GL-V9 reverses the resistance by suppressing the Trx-1/Ref-1 axis., PMID:25656992
Therapeutic Molecular Phenotype of β-Blocker-Associated Reverse-Remodeling in Nonischemic Dilated Cardiomyopathy., PMID:25637602
Phenylbutyrate increases pyruvate dehydrogenase complex activity in cells harboring a variety of defects., PMID:25356417
Founder p.Arg 446* mutation in the PDHX gene explains over half of cases with congenital lactic acidosis in Roma children., PMID:25087164
MicroRNA-26a regulates glucose metabolism by direct targeting PDHX in colorectal cancer cells., PMID:24935220
Mining the pre-diagnostic antibody repertoire of TgMMTV-neu mice to identify autoantibodies useful for the early detection of human breast cancer., PMID:24886063
The heart is better protected against myocardial infarction in the fed state compared to the fasted state., PMID:24140100
Pyruvate dehydrogenase deficiency caused by a new mutation of PDHX gene in two Moroccan patients., PMID:22766002
Possible therapeutic effects of myxobacterial metabolites on type I Gaucher disease., PMID:22634098
Molecular characterization of 82 patients with pyruvate dehydrogenase complex deficiency. Structural implications of novel amino acid substitutions in E1 protein., PMID:21914562
Identification of a systemic lupus erythematosus susceptibility locus at 11p13 between PDHX and CD44 in a multiethnic study., PMID:21194677
Butyrylcholinesterase in metabolic syndrome., PMID:20797821
Characterization of interactions of dihydrolipoamide dehydrogenase with its binding protein in the human pyruvate dehydrogenase complex., PMID:20385101
For research use only. Not for human or drug use.
