Catalog No.
YHA06001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg207-Pro440
Predicted molecular weight
27.43 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O00221
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
IkB-E, IKBE, IkappaBepsilon, I-kappa-B-epsilon, IkB-epsilon, NFKBIE, NF-kappa-B inhibitor epsilon, NF-kappa-BIE
Sanguinoderma rugosum (Agaricomycetes), a Wild Malaysian Medicinal Mushroom, Triggers Anti-Neuroinflammatory Genes Expression in LPS-Stimulated BV-2 Microglial Cells., PMID:40460400
Bailixiang tea, an herbal medicine formula, co-suppresses TLR2/MAPK8 and TLR2/NF-κB signaling pathways to protect against LPS-triggered cytokine storm in mice., PMID:39265795
NFKBIE is a predictive factor of survival and is correlated with immune infiltration and antigen processing and presentation in hepatocellular carcinoma., PMID:39161335
A bioinformatics approach to systematically analyze the molecular patterns of monkeypox virus-host cell interactions., PMID:38737277
A novel PD-1/PD-L1 pathway-related seven-gene signature for the development and validation of the prognosis prediction model for breast cancer., PMID:38617520
IκBε deficiency accelerates disease development in chronic lymphocytic leukemia., PMID:38575671
NFKBIE mutations are selected by the tumor microenvironment and contribute to immune escape in chronic lymphocytic leukemia., PMID:38486128
From Fruit Waste to Medical Insight: The Comprehensive Role of Watermelon Rind Extract on Renal Adenocarcinoma Cellular and Transcriptomic Dynamics., PMID:37958599
Lost and Found: The Family of NF-κB Inhibitors Is Larger than Assumed in Salmonid Fish., PMID:37373375
Cellular myofibromas with SRF fusions: clinicopathological and molecular study of 3 cases of a rare entity and a potential mimic of sarcoma., PMID:37245628
BTK and PLCG2 remain unmutated in one-third of patients with CLL relapsing on ibrutinib., PMID:36696464
Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY., PMID:36566271
Targeted sequencing reveals the relationship between mutations and patients' clinical indicators, blood cell counts and early progression in diffuse large-B cell lymphoma., PMID:36215154
Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection., PMID:36119054
Histiocytic Sarcoma With CCND1 Gene Rearrangement Clonally Related and Transdifferentiated From Mantle Cell Lymphoma., PMID:35964234
A Global Regulatory Network for Dysregulated Gene Expression and Abnormal Metabolic Signaling in Immune Cells in the Microenvironment of Graves' Disease and Hashimoto's Thyroiditis., PMID:35720300
Genetic variation influencing DNA methylation provides insights into molecular mechanisms regulating genomic function., PMID:34980917
Assessment of genetic polymorphisms within nuclear factor-κB signaling pathway genes in rheumatoid arthritis: Evidence for replication and genetic interaction., PMID:34464884
RTEC-intrinsic IL-17-driven inflammatory circuit amplifies antibody-induced glomerulonephritis and is constrained by Regnase-1., PMID:34236049
Anti-Metastatic and Anti-Angiogenic Effects of Curcumin Analog DK1 on Human Osteosarcoma Cells In Vitro., PMID:34204873
NF-кB pathway genes expression in chicken erythrocytes infected with avian influenza virus subtype H9N2., PMID:33843365
T-cell receptors provide potential prognostic signatures for breast cancer., PMID:33527533
Computationally predicted SARS-COV-2 encoded microRNAs target NFKB, JAK/STAT and TGFB signaling pathways., PMID:33398248
Predictive significance of selected gene mutations in relapsed and refractory chronic lymphocytic leukemia patients treated with ibrutinib., PMID:33190294
SRF Fusions Other Than With RELA Expand the Molecular Definition of SRF-fused Perivascular Tumors., PMID:33021523
Identification of clinical molecular targets for childhood Burkitt lymphoma., PMID:32947237
Genome-wide identification of genes regulating DNA methylation using genetic anchors for causal inference., PMID:32859263
The NF-κB signalling pathway regulates GLUT6 expression in endometrial cancer., PMID:32512041
17-Aminogeldanamycin Inhibits Constitutive Nuclear Factor-Kappa B (NF-κB) Activity in Patient-Derived Melanoma Cell Lines., PMID:32466509
Nfkbie-deficiency leads to increased susceptibility to develop B-cell lymphoproliferative disorders in aged mice., PMID:32170099
Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial., PMID:32015491
High throughput sequencing reveals high specificity of TNFAIP3 mutations in ocular adnexal marginal zone B-cell lymphomas., PMID:32012328
Two functional variants at 6p21.1 were associated with lean mass., PMID:31757224
Gene expression and DNA methylation changes in BeWo cells dependent on tumor necrosis factor-α and insulin-like growth factor-I., PMID:31724103
Dissection of subclonal evolution by temporal mutation profiling in chronic lymphocytic leukemia patients treated with ibrutinib., PMID:31180577
Prediction of the presence of a seventh ankyrin repeat in IκBε from homology modeling combined with hydrogen-deuterium exchange mass spectrometry (HDX-MS)., PMID:30133030
Molecular Mechanisms of Disease Progression in Primary Cutaneous Diffuse Large B-Cell Lymphoma, Leg Type during Ibrutinib Therapy., PMID:29899297
Genomic Analyses Identify Recurrent Alterations in Immune Evasion Genes in Diffuse Large B-Cell Lymphoma, Leg Type., PMID:29857068
Genetic susceptibility to invasive pneumococcal disease., PMID:29407193
Trichloroethylene perturbs HNF4a expression and activity in the developing chick heart., PMID:29306027
IL-1/inhibitory κB kinase ε-induced glycolysis augment epithelial effector function and promote allergic airways disease., PMID:29108965
Exploratory plasma proteomic analysis in a randomized crossover trial of aspirin among healthy men and women., PMID:28542447
Functional importance of stripping in NFκB signaling revealed by a stripping-impaired IκBα mutant., PMID:28167786
Frequent NFKBIE deletions are associated with poor outcome in primary mediastinal B-cell lymphoma., PMID:27670424
NF-κB activation in chronic lymphocytic leukemia: A point of convergence of external triggers and intrinsic lesions., PMID:27491692
The Nuclear Protein IκBζ Forms a Transcriptionally Active Complex with Nuclear Factor-κB (NF-κB) p50 and the Lcn2 Promoter via the N- and C-terminal Ankyrin Repeat Motifs., PMID:27489104
BRCA1 affects protein phosphatase 6 signalling through its interaction with ANKRD28., PMID:27026398
Improving gastric cancer preclinical studies using diverse in vitro and in vivo model systems., PMID:26955870
Genetic Variation in NFKBIE Is Associated With Increased Risk of Pneumococcal Meningitis in Children., PMID:26870821
Network-assisted analysis of primary Sjögren's syndrome GWAS data in Han Chinese., PMID:26686423
For research use only. Not for human or drug use.
