Catalog No.
YHA01301
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Gln1119-Thr1348
Predicted molecular weight
27.58 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A8K2U0
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CPAMD9, A2ML1, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9, Alpha-2-macroglobulin-like protein 1
A2ML1 and otitis media: novel variants, differential expression, and relevant pathways. PMID: 31009165
Human PZP and common marmoset A2ML1 as pregnancy related proteins. PMID: 32198464
Recent advances in RASopathies. PMID: 26446362
The clinical significance of A2ML1 variants in Noonan syndrome has to be reconsidered. PMID: 33082526
Rare A2ML1 variants confer susceptibility to otitis media. PMID: 26121085
Noonan syndrome-causing genes: Molecular update and an assessment of the mutation rate. PMID: 30805484
Detection of autoantibodies against alpha-2-macroglobulin-like 1 in paraneoplastic pemphigus sera utilizing novel green fluorescent protein-based immunoassays. PMID: 32439251
Genetic counseling in an indigenous Filipino community with a high prevalence of A2ML1-related otitis media. PMID: 29949068
Transcriptional Profiling of Human Peripheral Blood Mononuclear Cells Identifies Diagnostic Biomarkers That Distinguish Active and Latent Tuberculosis. PMID: 31921195
Heterozygous germline mutations in A2ML1 are associated with a disorder clinically related to Noonan syndrome. PMID: 24939586
Multi-omics analysis based on integrated genomics, epigenomics and transcriptomics in pancreatic cancer. PMID: 32048534
伪2-Macroglobulin-like protein 1 can conjugate and inhibit proteases through their hydroxyl groups, because of an enhanced reactivity of its thiol ester. PMID: 32978260
Anti-伪-2-macroglobulin-like-1 autoantibodies are detected frequently and may be pathogenic in paraneoplastic pemphigus. PMID: 23407400
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. PMID: 27618447
Middle ear microbiome differences in indigenous Filipinos with chronic otitis media due to a duplication in the A2ML1 gene. PMID: 27799062
Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population. PMID: 27484237
Current Understanding of Host Genetics of Otitis Media. PMID: 32117425
A novel protease inhibitor of the alpha2-macroglobulin family expressed in the human epidermis. PMID: 16298998
Expansion of the RASopathies. PMID: 27942422
Recent Perspectives on Gene-Microbe Interactions Determining Predisposition to Otitis Media. PMID: 31850076
Genomics of Otitis Media (OM): Molecular Genetics Approaches to Characterize Disease Pathophysiology. PMID: 32391049
TRIM58/cg26157385 methylation is associated with eight prognostic genes in lung squamous cell carcinoma. PMID: 29749538
Digenic inheritance of subclinical variants in Noonan Syndrome patients: an alternative pathogenic model? PMID: 32514133
Paraneoplastic autoimmune multiorgan syndrome (PAMS): Beyond the single phenotype of paraneoplastic pemphigus. PMID: 30103046
Laboratory diagnosis of paraneoplastic pemphigus. PMID: 23796242
Differentially expressed genes and key molecules of BRCA1/2-mutant breast cancer: evidence from bioinformatics analyses. PMID: 31998560
Clinical and immunological findings in 104 cases of paraneoplastic pemphigus. PMID: 26358412
Noonan Syndrome in South Africa: Clinical and Molecular Profiles. PMID: 31057598
iTRAQ-based quantitative proteomic analysis of Takifugu fasciatus liver in response to low-temperature stress. PMID: 30954612
External ear anomalies and hearing impairment in Noonan Syndrome. PMID: 25862627
[Clinical and genetic analysis of Verheij syndrome caused by PUF60 de novo mutation in a Chinese boy and literature review]. PMID: 30078240
A gene co-association network regulating gut microbial communities in a Duroc pig population. PMID: 33612109
Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies. PMID: 29402968
The use of Human Inflammatory Response and Autoimmunity RT2 lncRNA PCR Array for plasma examination in breast cancer patients prior to therapy. PMID: 30943749
Otitis media susceptibility and shifts in the head and neck microbiome due to SPINK5 variants. PMID: 32709676
Comprehensive massive parallel DNA sequencing strategy for the genetic diagnosis of the neuro-cardio-facio-cutaneous syndromes. PMID: 24896146
Genomic Regions and Candidate Genes Linked to Capped Hock in Pig. PMID: 34073088
The protease inhibitor alpha-2-macroglobulin-like-1 is the p170 antigen recognized by paraneoplastic pemphigus autoantibodies in human. PMID: 20805888
Borderline personality disorder and childhood maltreatment: a genome-wide methylation analysis. PMID: 25612291
Comprehensive proteomic study identifies serpin and cystatin antiproteases as novel correlates of HIV-1 resistance in the cervicovaginal mucosa of female sex workers. PMID: 21973077
Association Between Brain Gene Expression, DNA Methylation, and Alteration of Ex Vivo Magnetic Resonance Imaging Transverse Relaxation in Late-Life Cognitive Decline. PMID: 29084334
A complex of novel protease inhibitor, ovostatin homolog, with its cognate proteases in immature mice uterine luminal fluid. PMID: 30899053
Changes in salivary proteome before and after cigarette smoking in smokers compared to sham smoking in nonsmokers: A pilot study. PMID: 34239408
Urine protein biomarkers for the diagnosis and prognosis of necrotizing enterocolitis in infants. PMID: 24433829
Integrative network analysis revealed molecular mechanisms of urine urea output in lactating dairy cows: Potential solutions to reduce environmental nitrate contamination. PMID: 33774166
Binding of alpha2ML1 to the low density lipoprotein receptor-related protein 1 (LRP1) reveals a new role for LRP1 in the human epidermis. PMID: 18648652
Expression of Panza, an alpha2-macroglobulin, in a restricted dorsal domain of the primitive gut in Xenopus laevis. PMID: 16275122
For research use only. Not for human or drug use.
