Catalog No.
YHA00601
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Arg100
Predicted molecular weight
13.07 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
A6NFN3
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Neuronal nuclei antigen, RBFOX3, RNA binding protein fox-1 homolog 3, NeuN antigen, Fox-1 homolog C
RBFOX3/NeuN is dispensable for visual function. PMID: 29401485
RBFOX3 Promotes Gastric Cancer Growth and Progression by Activating HTERT Signaling. PMID: 32903312
Rbfox3/NeuN Regulates Alternative Splicing of Tau Exon 10. PMID: 30475774
RBFOX3 Regulates the Chemosensitivity of Cancer Cells to 5-Fluorouracil via the PI3K/AKT, EMT and Cytochrome-C/Caspase Pathways. PMID: 29689552
RBFOX3/NeuN is Required for Hippocampal Circuit Balance and Function. PMID: 26619789
Rbfox3 controls the biogenesis of a subset of microRNAs. PMID: 25240799
RBFOX3 regulates Claudin-1 expression in human lung tissue via attenuation of proteasomal degradation. PMID: 28126724
RBFOX3 Promotes Tumor Growth and Progression via hTERT Signaling and Predicts a Poor Prognosis in Hepatocellular Carcinoma. PMID: 28839469
Rbfox3-regulated alternative splicing of Numb promotes neuronal differentiation during development. PMID: 23420872
Genetic variants in RBFOX3 are associated with sleep latency. PMID: 27142678
Melatonin inhibits MLL-rearranged leukemia via RBFOX3/hTERT and NF-kappaB/COX-2 signaling pathways. PMID: 30550850
Neuronal Splicing Regulator RBFOX3 (NeuN) Regulates Adult Hippocampal Neurogenesis and Synaptogenesis. PMID: 27701470
Identification and characterization of the RNA-binding protein Rbfox3 in zebrafish embryo. PMID: 26952657
Retraction: RBFOX3 Promotes Gastric Cancer Growth and Progression by Activating HTERT Signaling. PMID: 34532292
NeuN/Rbfox3 nuclear and cytoplasmic isoforms differentially regulate alternative splicing and nonsense-mediated decay of Rbfox2. PMID: 21747913
Transforming Growth Factor-beta-Induced RBFOX3 Inhibition Promotes Epithelial-Mesenchymal Transition of Lung Cancer Cells. PMID: 27432190
WDR45 contributes to neurodegeneration through regulation of ER homeostasis and neuronal death. PMID: 31204559
Chronic HIV-1 Tat and HIV reduce Rbfox3/NeuN: evidence for sex-related effects. PMID: 25760045
Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development. PMID: 25044120
PLA2G4A/cPLA2-mediated lysosomal membrane damage leads to inhibition of autophagy and neurodegeneration after brain trauma. PMID: 31238788
RBFOX1 and RBFOX3 mutations in rolandic epilepsy. PMID: 24039908
Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits. PMID: 31234698
Neuronal-targeted TFEB rescues dysfunction of the autophagy-lysosomal pathway and alleviates ischemic injury in permanent cerebral ischemia. PMID: 30304977
Autophagy modulates SNCA/伪-synuclein release, thereby generating a hostile microenvironment. PMID: 25484190
Chronic oral application of a periodontal pathogen results in brain inflammation, neurodegeneration and amyloid beta production in wild type mice. PMID: 30281647
Tanycytic TSPO inhibition induces lipophagy to regulate lipid metabolism and improve energy balance. PMID: 31469345
Impaired autophagy flux is associated with neuronal cell death after traumatic brain injury. PMID: 25484084
Altered subcellular localization of the NeuN/Rbfox3 RNA splicing factor in HIV-associated neurocognitive disorders (HAND). PMID: 24215932
The molecular basis of the specificity and cross-reactivity of the NeuN epitope of the neuron-specific splicing regulator, Rbfox3. PMID: 24150744
Prader-Willi locus Snord116 RNA processing requires an active endogenous allele and neuron-specific splicing by Rbfox3/NeuN. PMID: 30124848
PARP14 inhibits microglial activation via LPAR5 to promote post-stroke functional recovery. PMID: 33317392
Differential Clinical Features in Colombian Patients With Rolandic Epilepsy and Suggestion of Unlikely Association With GRIN2A, RBFOX1, or RBFOX3 Gene Variants. PMID: 34039076
A pilot study on searching for peri-nuclear NeuN-positive cells. PMID: 31938576
Immunohistochemical Femoral Nerve Study Following Bisphosphonates Administration. PMID: 32204565
Rbfox family proteins make the homo- and hetero-oligomeric complexes. PMID: 29170129
Genetic variants in splicing factor genes and susceptibility to bladder cancer. PMID: 34673209
Novel Insights into NeuN: from Neuronal Marker to Splicing Regulator. PMID: 25680637
Arx expansion mutation perturbs cortical development by augmenting apoptosis without activating innate immunity in a mouse model of X-linked infantile spasms syndrome. PMID: 32033960
Subcutaneous priming of protein-functionalized chitosan scaffolds improves function following spinal cord injury. PMID: 32204084
Relative Resilience of Cerebellar Purkinje Cells in a Cardiac Arrest/Resuscitation Rat Model. PMID: 31396839
Sovateltide (IRL-1620) activates neuronal differentiation and prevents mitochondrial dysfunction in adult mammalian brains following stroke. PMID: 32728189
For research use only. Not for human or drug use.
