Catalog No.
DHD72504
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Humanized
Isotype
VH-VL-VH'-VL'
Clonality
Monoclonal
Target
IL-3R subunit alpha, IL-3 receptor subunit alpha, CD123, Interleukin-3 receptor subunit alpha, IL3R, IL-3R-alpha, IL3RA, IL-3RA, T3E, T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, CD3E, T-cell surface glycoprotein CD3 epsilon chain
Concentration
1 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Purified by Nickel column.
Accession
P26951 & P07766
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
Bispecific, MGD-006, MGD006, RES234, S80880, CAS: 1664355-28-5
Clone ID
Flotetuzumab
Flotetuzumab as salvage immunotherapy for refractory acute myeloid leukemia, PMID: 32929488
TP53 abnormalities correlate with immune infiltration and associate with response to flotetuzumab immunotherapy in AML, PMID: 33057635
Immune landscapes predict chemotherapy resistance and immunotherapy response in acute myeloid leukemia, PMID: 32493790
Immune therapies in acute myeloid leukemia: a focus on monoclonal antibodies and immune checkpoint inhibitors, PMID: 29206680
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy, PMID: 33177106
Bispecific Antibodies for the Treatment of Acute Myeloid Leukemia, PMID: 30280288
Integrated Pharmacokinetic/Pharmacodynamic Model of a Bispecific CD3xCD123 DART Molecule in Nonhuman Primates: Evaluation of Activity and Impact of Immunogenicity, PMID: 29463552
Targeting the alpha subunit of IL-3 receptor (CD123) in patients with acute leukemia, PMID: 32692611
An Update on the Clinical Evaluation of Antibody-Based Therapeutics in Acute Myeloid Leukemia, PMID: 33630233
For research use only. Not for human or drug use.
