Catalog No.
YHB09001
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Met1-Glu193
Predicted molecular weight
23.42 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O75113
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
NEDD4-binding protein 1, N4BP1, 3.1.-.-, N4BP1, KIAA0615
N4BP1 as a modulator of the NF-κB pathway., PMID:40312219
Exosomal miR-92b-5p regulates N4BP1 to enhance PTEN mono-ubiquitination in doxorubicin-resistant AML., PMID:40201312
Exogenous RNA surveillance by proton-sensing TRIM25., PMID:40179174
NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs., PMID:40111401
Structural and functional characterization of the extended-diKH domain from the antiviral endoribonuclease KHNYN., PMID:39984050
Functional anatomy of zinc finger antiviral protein complexes., PMID:39738020
Enteroviral 3C protease cleaves N4BP1 to impair the host inflammatory response., PMID:39655957
The NEDD4-binding protein N4BP1 degrades mRNA substrates through the coding sequence independent of nonsense-mediated decay., PMID:39491646
MALT1 substrate cleavage: what is it good for?, PMID:38863711
Non-canonical IKKs side with N4BP1 against the family., PMID:38749393
N4BP1 coordinates ubiquitin-dependent crosstalk within the IκB kinase family to limit Toll-like receptor signaling and inflammation., PMID:38697117
N4BP1 functions as a dimerization-dependent linear ubiquitin reader which regulates TNF signalling., PMID:38643192
Identification of novel prognostic autoantibodies in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone via a high-throughput antigen microarray., PMID:38133926
N4BP1 mediates RAM domain-dependent notch signaling turnover during neocortical development., PMID:37807845
Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia., PMID:37763159
N4BP1 regulates keratinocytes development and plays protective role in burn- and adhesive-related skin injury via MMP9., PMID:37579928
A Nuclear Export Signal in KHNYN Required for Its Antiviral Activity Evolved as ZAP Emerged in Tetrapods., PMID:36633408
Porcine Reproductive and Respiratory Syndrome Virus Adapts Antiviral Innate Immunity via Manipulating MALT1., PMID:35467421
CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis., PMID:35002536
Regnase-1-related endoribonucleases in health and immunological diseases., PMID:34514623
N4BP2L1 interacts with dynactin and contributes to GLUT4 trafficking and glucose uptake in adipocytes., PMID:34197691
Beraprost ameliorates postmenopausal osteoporosis by regulating Nedd4-induced Runx2 ubiquitination., PMID:33993186
The endoribonuclease N4BP1 prevents psoriasis by controlling both keratinocytes proliferation and neutrophil infiltration., PMID:33990547
N4BP1 negatively regulates NF-κB by binding and inhibiting NEMO oligomerization., PMID:33654074
Analysis of Protein Intermolecular Interactions with MAFFT-DASH., PMID:33289893
Integration of innate immune signalling by caspase-8 cleavage of N4BP1., PMID:32971525
Cellular Factors Targeting HIV-1 Transcription and Viral RNA Transcripts., PMID:32365692
Old and New Concepts in Ubiquitin and NEDD8 Recognition., PMID:32272761
miR-28-5p inhibits carcinogenesis in colon cancer cells and is necessary for erastin-induced ferroptosis., PMID:35117649
Human microRNA-30 inhibits influenza virus infection by suppressing the expression of SOCS1, SOCS3, and NEDD4., PMID:31876380
CoCUN, a Novel Ubiquitin Binding Domain Identified in N4BP1., PMID:31319543
N4BP1 restricts HIV-1 and its inactivation by MALT1 promotes viral reactivation., PMID:31133753
Nedd4-Binding Protein 1 and TNFAIP3-Interacting Protein 1 Control MHC-1 Display in Neuroblastoma., PMID:30213788
The miRNA Pull Out Assay as a Method to Validate the miR-28-5p Targets Identified in Other Tumor Contexts in Prostate Cancer., PMID:29085832
miR-28-5p promotes the development and progression of ovarian cancer through inhibition of N4BP1., PMID:28350078
Mechanistic and Structural Studies of Protein-Only RNase P Compared to Ribonucleoproteins Reveal the Two Faces of the Same Enzymatic Activity., PMID:27348014
The anti-HER3 (ErbB3) therapeutic antibody 9F7-F11 induces HER3 ubiquitination and degradation in tumors through JNK1/2- dependent ITCH/AIP4 activation., PMID:27203743
Identification of a novel N4BP1-like gene from grass carp (Ctenopharyngodon idella) in response to GCRV infection., PMID:24220004
Genistein suppresses prostate cancer growth through inhibition of oncogenic microRNA-151., PMID:22928040
Global analysis of the mammalian RNA degradome reveals widespread miRNA-dependent and miRNA-independent endonucleolytic cleavage., PMID:21427086
N4BP1 is a newly identified nucleolar protein that undergoes SUMO-regulated polyubiquitylation and proteasomal turnover at promyelocytic leukemia nuclear bodies., PMID:20233849
CGIN1: a retroviral contribution to mammalian genomes., PMID:19561090
Identification of polyubiquitin binding proteins involved in NF-kappaB signaling using protein arrays., PMID:19285159
The Nedd4-binding partner 1 (N4BP1) protein is an inhibitor of the E3 ligase Itch., PMID:17592138
For research use only. Not for human or drug use.
