Catalog No.
YHA52401
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asn406-Val465
Predicted molecular weight
34.94 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
O15427
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Monocarboxylate transporter 4, MCT 4, Solute carrier family 16 member 3, SLC16A3, MCT3, MCT4
Transmembrane Protease Serine 11B Modulates Lactate Transport Through SLC16A1 in Pancreatic Ductal Adenocarcinoma-A Functional Link to Phenotype Heterogeneity., PMID:40508207
Integrating analysis of multi-omics summary data identifies novel plasma protein biomarkers and drug targets for bladder cancer., PMID:40316856
Comprehensive pan-cancer analysis identified SLC16A3 as a potential prognostic and diagnostic biomarker., PMID:40301866
From COPD to cancer: indacaterol's unexpected role in combating NSCLC., PMID:40276602
Transcriptional Expression of SLC2A3 and SDHA Predicts the Risk of Local Tumor Recurrence in Patients with Head and Neck Squamous Cell Carcinomas Treated Primarily with Radiotherapy or Chemoradiotherapy., PMID:40141095
Altered structural and transporter-related gene expression patterns in the placenta play a role in fetal demise during Porcine reproductive and respiratory syndrome virus infection., PMID:40119254
Knocking down the neuronal lactate transporter MCT2 in the arcuate nucleus of female rats increases food intake and body weight., PMID:40032881
Mutant KRAS and CK2 Cooperatively Stimulate SLC16A3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression., PMID:39854318
Age-associated microglial transcriptome leads to diminished immunogenicity and dysregulation of MCT4 and P2RY12/P2RY13 related functions., PMID:39828750
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation., PMID:39657846
Integrated Single-Cell and Spatial Transcriptome Reveal Metabolic Gene SLC16A3 as a Key Regulator of Immune Suppression in Hepatocellular Carcinoma., PMID:39656344
Postischemic inactivation of HIF prolyl hydroxylases in endothelium promotes maladaptive kidney repair by inducing glycolysis., PMID:39621585
The Solute Carrier (SLC) Transporter Superfamily as Therapeutic Targets for the Treatment of Head and Neck Squamous Cell Carcinoma., PMID:39335197
Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis., PMID:39303526
Prenatal opioid exposure significantly impacts placental protein kinase C (PKC) and drug transporters, leading to drug resistance and neonatal opioid withdrawal syndrome., PMID:39238930
Propofol pretreatment inhibits ferroptosis and alleviates myocardial ischemia-reperfusion injury through the SLC16A13-AMPK-GPX4 pathway., PMID:39208667
Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord injury., PMID:38993124
Solute Carrier Transporters in Synovial Membrane and Hoffa's Pad of Patients with Rheumatoid Arthritis., PMID:38932672
Exploration of Immune-Modulatory Effects of Amivantamab in Combination with Pembrolizumab in Lung and Head and Neck Squamous Cell Carcinoma., PMID:38916448
Transporter Protein Expression of Corneal Epithelium in Rabbit and Porcine: Evaluation of Models for Ocular Drug Transport Study., PMID:38809137
Adenosine kinase inhibits β-cell proliferation by upregulating DNA methyltransferase 3A expression., PMID:38699782
MCT4 and CD147 colocalize with MMP14 in invadopodia and support matrix degradation and invasion by breast cancer cells., PMID:38661040
Metabolic pathways of glucose and fructose: II Spatiotemporal expression of genes involved in synthesis and transport of lactate in ovine conceptuses†., PMID:38531778
Targeting tumor-intrinsic SLC16A3 to enhance anti-PD-1 efficacy via tumor immune microenvironment reprogramming., PMID:38522774
A Lactic Acid Metabolism-Related Gene Signature for Predicting Clinical Outcome and Tumor Microenvironmental Status in Patients with Hepatocellular Carcinoma., PMID:38226887
A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions., PMID:37934721
Gene purging and the evolution of Neoave metabolism and longevity., PMID:37918802
Identification of Intron Retention in the Slc16a3 Gene Transcript Encoding the Transporter MCT4 in the Brain of Aged and Alzheimer-Disease Model (APPswePS1dE9) Mice., PMID:37895298
Paralog-dependent isogenic cell assay cascade generates highly selective SLC16A3 inhibitors., PMID:37516113
Construction of SLC16A1/3 Targeted Gallic Acid-Iron-Embelin Nanoparticles for Regulating Glycolysis and Redox Pathways in Cervical Cancer., PMID:37307591
Differential effect of lactate on synovial fibroblast and macrophage effector functions., PMID:37304267
Interaction between Butyrate and Tumor Necrosis Factor α in Primary Rat Colonocytes., PMID:36830627
Glycolysis-Related Gene Analyses Indicate That DEPDC1 Promotes the Malignant Progression of Oral Squamous Cell Carcinoma via the WNT/β-Catenin Signaling Pathway., PMID:36768316
Lactate from glycolysis regulates inflammatory macrophage polarization in breast cancer., PMID:36729212
Pan-Cancer Analysis Identifies Tumor Cell Surface Targets for CAR-T Cell Therapies and Antibody Drug Conjugates., PMID:36428765
Transcription profiling of feline mammary carcinomas and derived cell lines reveals biomarkers and drug targets associated with metabolic and cell cycle pathways., PMID:36220861
Involvement of SLC16A1/MCT1 and SLC16A3/MCT4 in l-lactate transport in the hepatocellular carcinoma cell line., PMID:36104287
Cancer-Associated Stromal Fibroblast-Derived Transcriptomes Predict Poor Clinical Outcomes and Immunosuppression in Colon Cancer., PMID:35991839
Joint Transcriptome and Metabolome Analysis Prevails the Biological Mechanisms Underlying the Pro-Survival Fight in In Vitro Heat-Stressed Granulosa Cells., PMID:35741360
Introduction of mutant TP53 related genes in metabolic pathways and evaluation their correlation with immune cells, drug resistance and sensitivity., PMID:35667517
Epigenome-wide DNA methylation signature of plasma zinc and their mediation roles in the association of zinc with lung cancer risk., PMID:35654255
Transcriptome Reveals Granulosa Cells Coping through Redox, Inflammatory and Metabolic Mechanisms under Acute Heat Stress., PMID:35563749
Differential expression and analysis of extrachromosomal circular DNAs as serum biomarkers in lung adenocarcinoma., PMID:35441736
SOX2 mediates metabolic reprogramming of prostate cancer cells., PMID:35067686
Identification and Validation of a Prognostic Model Based on Three MVI-Related Genes in Hepatocellular Carcinoma., PMID:34975331
Metabolic drug survey highlights cancer cell dependencies and vulnerabilities., PMID:34907165
MCT4 as a potential therapeutic target to augment gemcitabine chemosensitivity in resected pancreatic cancer., PMID:34791637
Construction of a competing endogenous RNA network related to the prognosis of cholangiocarcinoma and comprehensive analysis of the immunological correlation., PMID:34790393
Lactate transporters in the rat barrel cortex sustain whisker-dependent BOLD fMRI signal and behavioral performance., PMID:34782470
LINC00035 Transcriptional Regulation of SLC16A3 via CEBPB Affects Glycolysis and Cell Apoptosis in Ovarian Cancer., PMID:34671407
For research use only. Not for human or drug use.
