Catalog No.
PHK84301
Species reactivity
Human
Host species
Rabbit
Isotype
IgG
Clonality
Polyclonal
Immunogen
E. coli - derived recombinant Human CADM3/NECL-1/TSLL1 (Asn25-His330).
Applications
ELISA, IHC, WB
Recommended Dilution
| Application |
Dilution |
| ELISA |
1:4000-1:8000, IHC: 1:50-1:100, WB: 1:1000-1:4000 |
Target
TSLL1, Immunoglobulin superfamily member 4B, Brain immunoglobulin receptor, NECL1, CADM3, Synaptic cell adhesion molecule 3, Cell adhesion molecule 3, IgSF4B, NECL-1, Nectin-like protein 1, TSLC1-like protein 1, SynCAM3, SYNCAM3, IGSF4B
Purification
Purified by antigen affinity column.
Accession
Q8N126
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Note
For research use only.
Isolation of the TSLL1 and TSLL2 genes, members of the tumor suppressor TSLC1 gene family encoding transmembrane proteins., PMID:11536053
Crystal structure of the V domain of human Nectin-like molecule-1/Syncam3/Tsll1/Igsf4b, a neural tissue-specific immunoglobulin-like cell-cell adhesion molecule., PMID:16467305
Nectin-like molecule 1 is a glycoprotein with a single N-glycosylation site at N290KS which influences its adhesion activity., PMID:18420026
Loss of NECL1, a novel tumor suppressor, can be restored in glioma by HDAC inhibitor-Trichostatin A through Sp1 binding site., PMID:19062177
Embryonic corneal Schwann cells express some Schwann cell marker mRNAs, but no mature Schwann cell marker proteins., PMID:19387082
Localization of Cadm2a and Cadm3 proteins during development of the zebrafish nervous system., PMID:21456004
Synaptic adhesion molecules in Cadm family at the neuromuscular junction., PMID:23505055
Genetic deletion of Cadm4 results in myelin abnormalities resembling Charcot-Marie-Tooth neuropathy., PMID:23825401
Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis., PMID:26401960
Cadm3 (Necl-1) interferes with the activation of the PI3 kinase/Akt signaling cascade and inhibits Schwann cell myelination in vitro., PMID:27658374
miR-140-5p suppresses retinoblastoma cell proliferation, migration, and invasion by targeting CEMIP and CADM3., PMID:29808799
Necl-4/Cadm4 recruits Par-3 to the Schwann cell adaxonal membrane., PMID:30585357
Mass spectrometry-based analysis of cerebrospinal fluid from arthritis patients-immune-related candidate proteins affected by TNF blocking treatment., PMID:30770760
Undifferentiated pleomorphic sarcomas with PRDM10 fusions have a distinct gene expression profile., PMID:31313299
Differential Contribution of Cadm1-Cadm3 Cell Adhesion Molecules to Peripheral Myelinated Axons., PMID:33397712
A CADM3 variant causes Charcot-Marie-Tooth disease with marked upper limb involvement., PMID:33889941
Cataloguing experimentally confirmed 80.7 kb-long ACKR1 haplotypes from the 1000 Genomes Project database., PMID:34039276
Circ004463 promotes fibroblast proliferation and collagen I synthesis by sponging miR-23b and regulating CADM3/MAP4K4 via activation of AKT/ERK pathways., PMID:36502948
Pseudo-Dystonia and Marked Intrafamilial Variability in CADM3-Related Disease., PMID:37196599
Clinical significance of low expression of CADM3 in breast cancer and preliminary exploration of related mechanisms., PMID:38515057
For research use only. Not for human or drug use.
