Catalog No.
YMJ72801
Expression system
E. coli
Species
Mus musculus (Mouse)
Protein length
Met1-Asp156
Predicted molecular weight
19.30 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9QYY1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
FIL1D, Interleukin-1 family member 5, IL-36Ra, IL1HY1, Interleukin-36 receptor antagonist protein, IL1RP3, IL-1RP3, IL-1ra homolog 1, Interleukin-1-like protein 1, IL-1-related protein 3, IL1L1, Interleukin-1 HY1, IL-1HY1, Interleukin-1 delta, FIL1 delta, IL-1 delta, IL-1L1, Interleukin-1 receptor antagonist homolog 1, IL36RN, IL1F5, IL-1F5
Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson's disease., PMID:40368903
Enhanced IL36RN Expression and Its Association With Immune Microenvironment Predicts Poor Prognosis in Gastric Cancer., PMID:40347070
Epidemiological, Genetic, Clinical, and Treatment Differences of Generalized Pustular Psoriasis and Acrodermatitis Continua of Hallopeau Across Ethnicities: A Systematic Review., PMID:40169503
Spesolimab for the Treatment of Generalized Pustular Psoriasis Flares., PMID:40043276
Analysis of the German Compassionate Use Program on spesolimab in patients with generalized pustular psoriasis: evidence outside of clinical trials., PMID:39912471
Case report: Successful treatment with spesolimab of acrodermatitis continua of Hallopeau in an older patient without IL36RN mutations., PMID:39882245
Destructive and protective effects and therapeutic targets of IL-36 family cytokines in dry eye disease., PMID:39800261
Updated genetic background of generalized pustular psoriasis as an autoinflammatory keratinization disease., PMID:39698752
Analysis of the role of IL-1 family and related genes in head and neck squamous cell carcinoma., PMID:39461030
IL36RN Mutations and Correlated Characteristics in Generalized Pustular Psoriasis Patients in Can Tho City, Vietnam: A Cross-Sectional Study., PMID:39378855
Spesolimab, the first-in-class anti-IL-36R antibody: From bench to clinic., PMID:39373152
A case of revertant mosaic-like normal-looking spots in a patient with erythroderma with IL36RN and CARD14 heterozygous mutations., PMID:39373130
Generalized pustular psoriasis patient with a heterozygous hypomorphic MPO variant refractory to intravenous spesolimab., PMID:39301845
TLR7/8 Activation in Immune Cells and Muscle by RNA-Containing Immune Complexes: Role in Inflammation and the Pathogenesis of Myositis., PMID:39279150
Autoantibody mediated deficiency of IL-36-receptor antagonist in a subset of patients with psoriasis and psoriatic arthritis., PMID:39265919
Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval., PMID:39104539
Erythema multiforme after initiating spesolimab in a patient with generalized pustular psoriasis with IL36RN mutation., PMID:39015980
TNFRSF11A variants contribute to systemic autoinflammatory diseases: A case series of 12 patients., PMID:39003954
Secukinumab and Dead Sea Climatotherapy Impact Resolved Psoriasis Skin Differently Potentially Affecting Disease Memory., PMID:38892277
Characteristics of psoriatic plaques in generalized pustular psoriasis patients with or without IL36RN mutation., PMID:38822916
Use of biologics in Chinese pregnant patients with deficiency of interleukin-36 receptor antagonist (DITRA): A case series., PMID:38802208
CXCL5/CXCL8 induces neutrophilic inflammation in peri-implantitis., PMID:38699841
Genetic analysis of different subtypes of aseptic pustulosis in the Chinese population., PMID:38651209
Generalized pustular psoriasis in a toddler with IL36RN mutation: a case report., PMID:38571950
Successful treatment of recalcitrant generalized pustular psoriasis of pregnancy with spesolimab., PMID:38565205
Acquired diffuse palmoplantar erythema with keratoderma in Chinese patients with pustular psoriasis: A predictor for IL36 receptor antagonist c.115+6T>C mutation?, PMID:38488485
Increased neutrophil-derived IL-17A identified in generalized pustular psoriasis., PMID:38414093
Paediatric pustulotic arthro-osteitis patient with an IL36RN variant, heterozygous c.115+6T>C, who was successfully treated with tonsillectomy: A case report and literature review., PMID:38284206
Spesolimab, A Novel Interleukin-36 Inhibitor for Generalized Pustular Psoriasis Flares in Adult Patients., PMID:38271532
Clinical advances in biological therapy for generalized pustular psoriasis: a review., PMID:38247394
Emerging Role of the IL-36/IL-36R Axis in Multiple Inflammatory Skin Diseases., PMID:38189700
Autoinflammatory Keratinization Diseases-The Concept, Pathophysiology, and Clinical Implications., PMID:38103162
The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab., PMID:38077370
Acute generalized exanthematous pustulosis caused by hydroxychloroquine in a patient with rheumatoid arthritis and CARD14 mutation: Case report., PMID:38013380
Mature IL-36γ Induces Stratum Corneum Exfoliation in Generalized Pustular Psoriasis by Suppressing Corneodesmosin., PMID:37827276
Cutaneous findings and treatments in deficiency of interleukin-36 receptor antagonist (DITRA): A review of the literature., PMID:37726967
Expression of interleukin-36 receptor antagonist in a patient with generalized pustular psoriasis harboring the p.Pro82Leu variant in the IL36RN gene., PMID:37525499
In Silico and In Vitro Analysis of IL36RN Alterations Reveals Critical Residues for the Function of the Interleukin-36 Receptor Complex., PMID:37414245
Genetics of Generalized Pustular Psoriasis: Current Understanding and Implications for Future Therapeutics., PMID:37372477
Transcriptomic responses of peripheral blood mononuclear cells to cyclosporin and etanercept in a female infant with juvenile generalized pustular psoriasis., PMID:37194367
Acrodermatitis continua of Hallopeau and generalised pustular psoriasis: Should they be the same or different entities?, PMID:37057764
Deficiency of interleukin-36 receptor antagonist (DITRA): An analysis of 58 Chinese patients in a tertiary hospital in Taiwan., PMID:36843341
Clinical profile of patients with acute generalized pustular psoriasis with and without IL36RN mutations in multi-ethnic Johor Bahru, Malaysia., PMID:36843152
Identification of the BTN3A3 Gene as a Molecule Implicated in Generalized Pustular Psoriasis in a Chinese Population., PMID:36804966
Current management of generalized pustular psoriasis., PMID:36779681
Case report: Infantile generalized pustular psoriasis with IL36RN and CARD14 gene mutations., PMID:36704338
A viewpoint on the genetic determinants of generalised pustular psoriasis., PMID:36645252
A homozygous loss-of-function variant in the MPO gene is associated with generalized pustular psoriasis., PMID:36585391
Different Clinical Features of Pediatric Generalized Pustular Psoriasis in Patients with or without IL36RN Variants., PMID:36577391
Correlation of IL36RN and CARD14 mutations with clinical manifestations and laboratory findings in patients with generalised pustular psoriasis., PMID:36331855
For research use only. Not for human or drug use.
