Catalog No.
EHG01802
Expression system
Mammalian Cells
Species
Homo sapiens (Human)
Protein length
Leu26-Arg1675
Predicted molecular weight
207 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q04721
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
N2ICD, N2ECD, NOTCH2, hN2, Neurogenic locus notch homolog protein 2, Notch 2
RBPJ/PAF1 Signaling Axis Promotes Cloning Expansion in Paroxysmal Nocturnal Hemoglobinuria Through NOTCH Signaling., PMID:40501337
Significance of Midkine Signaling in Women's Cancers: Novel Biomarker and Therapeutic Target., PMID:40429950
Snora54 negatively regulates self-renewal of intestinal stem cells and gut regeneration via suppression of Notch2 signaling., PMID:40408479
PRMT1-catalyzed NUSAP1 methylation enhances Notch2 signaling and 5-FU resistance in gastric cancer., PMID:40393971
Identification and Exploration of Pyroptosis-Related Genes in Macrophage Cells Reveal Necrotizing Enterocolitis Heterogeneity Through Single-Cell and Bulk-Sequencing., PMID:40362275
NOTCH2 disrupts the synovial fibroblast identity and the inflammatory response of epiphyseal chondrocytes., PMID:40345585
Understanding the role of NOTCH2 mutation in centronuclear myopathy., PMID:40336196
LianChuang ZhiXue Liquid Enema Modulates the Macrophage Polarization of Ulcerative Colitis via Inhibiting the Jagged-1/Notch1 Signaling Pathway., PMID:40308738
Gemcitabine and miRNA34a mimic codelivery with magnetic nanoparticles enhanced anti-tumor effect against pancreatic cancer., PMID:40306578
[Clinicopathological features of primary thoracic synovial sarcoma: a study of 42 cases]., PMID:40302578
[High expression of DTX2 promotes proliferation, invasion and epithelial-mesenchymal transition of oxaliplatin-resistant colorectal cancer cells]., PMID:40294933
Regulatory T Cells promote osteogenic differentiation of periodontal ligament stem cells through the Jagged1-Notch2 signaling Axis., PMID:40287047
Treatment outcomes of BTK inhibitors and venetoclax with or without anti-CD20 monoclonal antibody in relapsed or refractory mantle cell lymphoma., PMID:40278919
Curcumin prevents dexamethasone-induced activation of the pseudorabies virus in rat pheochromocytoma cells through the miR-155-5p-Aak1-Numb/Notch2 signalling axis., PMID:40259414
A dyad of human-specific NBPF14 and NOTCH2NLB orchestrates cortical progenitor abundance crucial for human neocortex expansion., PMID:40138416
Central Nervous System Manifestations of Cutaneous Lymphomas., PMID:40131611
Notch 2 from bone marrow mesenchymal stem cells alleviates smoke inhalation-induced lung injury by mediating alveolar cell differentiation., PMID:40119225
Novel De Novo BRCA2 Variant in an Early-Onset Ovarian Cancer Reveals a Unique Tumor Evolution Pathway., PMID:40076915
Alagille Syndrome: Unraveling the Complexities of Genotype-Phenotype Relationships and Exploring Avenues for Improved Diagnosis and Treatment., PMID:40042123
In vitro differentiation of macaque extravillous trophoblasts in a low oxygen environment., PMID:40024139
BIN1 inhibited tumor growth, metastasis and stemness by ALDH1/NOTCH pathway in bladder carcinoma., PMID:40016843
Hepatic factor MANF drives hepatocytes reprogramming by detaining cytosolic CK19 in intrahepatic cholangiocarcinoma., PMID:39972058
Notch2/3-DLL4 interaction in urothelial cancer cell lines supports a tumorigenic role of Notch signaling pathways in bladder carcinoma., PMID:39951484
Relationship between Genes and microRNAs Involved in the Migration of Cells from the Bone Marrow during Experimental Liver Fibrosis., PMID:39945950
Case report: Near-complete response to neratinib-based treatment in HR-positive HER2-amplified metastatic breast cancer refractory to trastuzumab deruxtecan., PMID:39931207
YTHDF3 drives tumor growth and metastasis by recruiting eIF4B to promote Notch2 translation in breast cancer., PMID:39924078
NOTCH1, 2, and 3 receptors enhance osteoblastogenesis of mesenchymal C3H10T1/2 cells and inhibit this process in preosteoblastic MC3T3-E1 cells., PMID:39879823
Genome-Wide Scans for Selection Signatures in Haimen Goats Reveal Candidate Genes Associated with Growth Traits., PMID:39857271
Notch dimerization provides robustness against environmental insults and is required for vascular integrity., PMID:39854367
Genetic alterations and their prognostic impact in marginal zone lymphoma: a meta-analysis., PMID:39820428
Combined exercise-induced modulation of Notch pathway and muscle quality in senescence-accelerated mice., PMID:39804464
Celastrol ameliorates fibrosis in Western diet/tetrachloromethane-induced nonalcoholic steatohepatitis by suppressing Notch/osteopontin signaling., PMID:39798343
High-risk MCL: recognition and treatment., PMID:39786418
PEAR1 Promotes Myoblast Proliferation Through Notch Signaling Pathway., PMID:39765730
Combined Molecular Subclass and Immune Phenotype Correlate to Atezolizumab Plus Radiation Therapy Response in Invasive Bladder Cancer: BPT-ART Phase 2 Study., PMID:39755215
Diversity in Notch ligand-receptor signaling interactions., PMID:39751380
Hajdu-Cheney Syndrome, a Rare Cause of Acro-Osteolysis and Osteoporosis With Zoledronic Acid Experience., PMID:39748536
Four SNPs in the untranslated region of the NOTCH2 gene involved in reproductive traits in fertile and anestrum Holstein Friesian cattle., PMID:39732698
Splenic fibroblasts control marginal zone B cell movement and function via two distinct Notch2-dependent regulatory programs., PMID:39731910
Echinococcus multilocularis delta/notch signalling components are expressed in post-mitotic cells., PMID:39714630
TP53 Mutation Is the Only Robust Mutational Biomarker for Outcome Found in a Consecutive Clinical Cohort of Real-Word Patients With Primary Large B-Cell Lymphoma., PMID:39691999
Somatic Recombination Between an Ancient and a Recent NOTCH2 Gene Variant Is Associated with the NOTCH2 Gain-of-Function Phenotype in Chronic Lymphocytic Leukemia., PMID:39684291
Loss of Notch dimerization perturbs intestinal homeostasis by a mechanism involving HDAC activity., PMID:39666740
The glycosyltransferase POGLUT1 regulates muscle stem cell development and maintenance in mice., PMID:39651163
Truncated recombinant Jagged1 fused with human IgG1 Fc activates Notch target genes in human periodontal ligament cells., PMID:39643955
The capicua-ataxin-1-like complex regulates Notch-driven marginal zone B cell development and sepsis progression., PMID:39632849
LncRNA SNHG14 Facilitates Cisplatin Resistance Through Upregulating Notch2 via Binding to U2AF2 in Nasopharyngeal Carcinoma., PMID:39604821
Targeting the NOTCH2/ADAM10/TCF7L2 Axis-Mediated Transcriptional Regulation of Wnt Pathway Suppresses Tumor Growth and Enhances Chemosensitivity in Colorectal Cancer., PMID:39601111
A NOTCH2 pathogenic variant and HES1 regulate osteoclastogenesis in induced pluripotent stem cells., PMID:39571704
Extracellular Vesicles Derived Ectonucleoside Triphosphate Diphosphohydrolase 3 Alleviates Mitochondrial Dysfunction of Osteoarthritis Chondrocytes via Ectonucleotide Pyrophosphatase/Phosphodiesterase 1-Induced Suppression of the AKT/Notch2 Pathway., PMID:39569601
For research use only. Not for human or drug use.
