Catalog No.
YVV31601
Expression system
E. coli
Species
Dengue virus type 2
Protein length
Ala1476-Lys2093
Predicted molecular weight
71.85 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
QNJ99448.1
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Genome polyprotein,Serine protease NS3
Darunavir inhibits dengue virus replication by targeting the hydrophobic pocket of the envelope protein., PMID:40024350
Achievements and Approaches in the Search for Small-Molecule Dengue NS2B/NS3 Inhibitors., PMID:39871573
Discovery of Potent Dengue Virus NS2B-NS3 Protease Inhibitors Among Glycyrrhizic Acid Conjugates with Amino Acids and Dipeptides Esters., PMID:39772233
Exploring antiviral activity of Betanin and Glycine Betaine against dengue virus type-2 in transfected Hela cells., PMID:39214424
Exploring the therapeutic potential of DV-B-120 as an inhibitor of dengue virus infection., PMID:38546211
Inhibition of dengue viruses by N-methylcytisine thio derivatives through targeting viral envelope protein and NS2B-NS3 protease., PMID:38242331
Investigating Lycotoxin-An1a (An1a), a defense antiviral peptide from Alopecosa nagpag venom as prospective anti-dengue agent against DENV-2 NS2B-NS3 protease., PMID:38157660
Exploring the viral protease inhibitor space driven by consensus scoring-based virtual screening., PMID:38050479
An ivermectin - atorvastatin combination impairs nuclear transport inhibiting dengue infection in vitro and in vivo., PMID:38034354
The Antiviral Activity of Varenicline against Dengue Virus Replication during the Post-Entry Stage., PMID:37893127
Evaluation of the inhibitory potency of anti-dengue phytocompounds against DENV-2 NS2B-NS3 protease: virtual screening, ADMET profiling and molecular dynamics simulation investigations., PMID:37194462
Transgene-induced cell death following dengue-2 virus infection in Aedes aegypti., PMID:37045866
N-sulfonyl peptide-hybrids as a new class of dengue virus protease inhibitors., PMID:36893626
A Transcriptomics-Based Bioinformatics Approach for Identification and In Vitro Screening of FDA-Approved Drugs for Repurposing against Dengue Virus-2., PMID:36298705
Evaluation of Melongosides as Potential Inhibitors of NS2B-NS3 Activator-Protease of Dengue Virus (Serotype 2) by Using Molecular Docking and Dynamics Simulation Approach., PMID:36051190
Discovery of potent benzoxaborole inhibitors against SARS-CoV-2 main and dengue virus proteases., PMID:35863275
Mapping of molecular interactions between human E3 ligase TRIM69 and Dengue virus NS3 protease using hydrogen-deuterium exchange mass spectrometry., PMID:35397701
1H, 13C and 15N resonance assignment of backbone and IVL-methyl side chain of the S135A mutant NS3pro/NS2B protein of Dengue II virus reveals unique secondary structure features in solution., PMID:35149939
In Vitro Antiviral Activity of α-Mangostin against Dengue Virus Serotype-2 (DENV-2)., PMID:34069351
Antiviral phytochemicals as potent inhibitors against NS3 protease of dengue virus., PMID:34022487
Natural DENV-2 NS2B/NS3 protease inhibitors from Myristica cinnamomea King., PMID:33973577
Beyond Basicity: Discovery of Nonbasic DENV-2 Protease Inhibitors with Potent Activity in Cell Culture., PMID:33851839
Degradation of MicroRNA miR-466d-3p by Japanese Encephalitis Virus NS3 Facilitates Viral Replication and Interleukin-1β Expression., PMID:32461319
A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques., PMID:31919100
Thioguanine-based DENV-2 NS2B/NS3 protease inhibitors: Virtual screening, synthesis, biological evaluation and molecular modelling., PMID:30677071
A quinoline compound inhibits the replication of dengue virus serotypes 1-4 in Vero cells., PMID:29583121
Aedes albopictus (Skuse, 1894) infected with the American-Asian genotype of dengue type 2 virus in Medellín suggests its possible role as vector of dengue fever in Colombia., PMID:29161485
Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus., PMID:28473813
Structural features of NS3 of Dengue virus serotypes 2 and 4 in solution and insight into RNA binding and the inhibitory role of quercetin., PMID:28471365
Identification of fused bicyclic derivatives of pyrrolidine and imidazolidinone as dengue virus-2 NS2B-NS3 protease inhibitors., PMID:27721158
Recombinant Dengue 2 Virus NS3 Helicase Protein Enhances Antibody and T-Cell Response of Purified Inactivated Vaccine., PMID:27035715
Detection of dengue NS1 and NS3 proteins in placenta and umbilical cord in fetal and maternal death., PMID:26792253
Flavonoid from Carica papaya inhibits NS2B-NS3 protease and prevents Dengue 2 viral assembly., PMID:24307765
Discovery and SAR studies of methionine-proline anilides as dengue virus NS2B-NS3 protease inhibitors., PMID:24268549
Design and docking studies of peptide inhibitors as potential antiviral drugs for dengue virus ns2b/ns3 protease., PMID:23855663
Differential targeting of viral components by CD4+ versus CD8+ T lymphocytes in dengue virus infection., PMID:23255803
Inhibition of dengue NS2B-NS3 protease and viral replication in Vero cells by recombinant retrocyclin-1., PMID:23171075
Protegrin-1 inhibits dengue NS2B-NS3 serine protease and viral replication in MK2 cells., PMID:23093838
Establishment of a robust dengue virus NS3-NS5 binding assay for identification of protein-protein interaction inhibitors., PMID:23072882
Small molecule pan-dengue and West Nile virus NS3 protease inhibitors., PMID:21566267
Dengue protease activity: the structural integrity and interaction of NS2B with NS3 protease and its potential as a drug target., PMID:21329491
Multiple enzyme activities of flavivirus proteins., PMID:17319155
Characterization of the West Nile virus protease substrate specificity and inhibitors., PMID:17188926
Dengue virus type 2 NS3 protease and NS2B-NS3 protease precursor induce apoptosis., PMID:12867651
For research use only. Not for human or drug use.
