Catalog No.
RHG84901
Species reactivity
Human
Host species
Human
Isotype
IgG4, kappa
Clonality
Monoclonal
Target
IL-11RA, sIL-11R, Interleukin-11 receptor subunit alpha, sIL-11RA, IL11RA, IL-11R-alpha, IL-11R subunit alpha, IL-11 receptor subunit alpha, sIL11RA
Concentration
0.84 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
Q14626
Applications
ELISA, FCM, WB
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Clone ID
SAA2023
Targeting carcinoma-associated mesothelial cells with antibody-drug conjugates in ovarian carcinomatosis., PMID:37555348
IL11 (Interleukin-11) Causes Emphysematous Lung Disease in a Mouse Model of Marfan Syndrome., PMID:36924234
Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease., PMID:36470928
IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues., PMID:36012165
IL11 stimulates ERK/P90RSK to inhibit LKB1/AMPK and activate mTOR initiating a mesenchymal program in stromal, epithelial, and cancer cells., PMID:35992082
Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury., PMID:35806094
IL11 Activates Pancreatic Stellate Cells and Causes Pancreatic Inflammation, Fibrosis and Atrophy in a Mouse Model of Pancreatitis., PMID:35408908
Interleukin-11 drives human and mouse alcohol-related liver disease., PMID:35365572
Inhibition of IL11 Signaling Reduces Aortic Pathology in Murine Marfan Syndrome., PMID:35135328
Therapeutic opportunities for senolysis in cardiovascular disease., PMID:35015342
A neutralizing IL-11 antibody reduces vessel hyperplasia in a mouse carotid artery wire injury model., PMID:34667238
Molecular Dissection of Pro-Fibrotic IL11 Signaling in Cardiac and Pulmonary Fibroblasts., PMID:34651016
The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling., PMID:34435951
Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury., PMID:34108253
IL11 is elevated in systemic sclerosis and IL11-dependent ERK signalling underlies TGFβ-mediated activation of dermal fibroblasts., PMID:33590875
Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload., PMID:33462828
IL-11 in cardiac and renal fibrosis: Late to the party but a central player., PMID:32022251
Chimeric antigen receptor T (CAR-T) cell immunotherapy for sarcomas: From mechanisms to potential clinical applications., PMID:31794912
Inhibiting Interleukin 11 Signaling Reduces Hepatocyte Death and Liver Fibrosis, Inflammation, and Steatosis in Mouse Models of Nonalcoholic Steatohepatitis., PMID:31078624
Immune profiling of pre- and post-treatment breast cancer tissues from the SWOG S0800 neoadjuvant trial., PMID:30967156
Mesenchymal stromal cells for bone sarcoma treatment: Roadmap to clinical practice., PMID:30956944
Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice., PMID:30268501
Therapeutically blocking Interleukin-11 Receptor-α enhances doxorubicin cytotoxicity in high grade type I endometrioid tumours., PMID:28186993
IL-11 regulates autoimmune demyelination., PMID:19734214
Enhancing engraftment of neonatal porcine xenoislet with CTLA4Ig and nordihydroguaiaretic acid., PMID:17175250
Expression of interleukin 11 and its receptor and their prognostic value in human breast cancer., PMID:16614887
Functional expression of the interleukin-11 receptor alpha-chain and evidence of antiapoptotic effects in human colonic epithelial cells., PMID:14701802
Nrl and Sp nuclear proteins mediate transcription of rod-specific cGMP-phosphodiesterase beta-subunit gene: involvement of multiple response elements., PMID:11438531
Interleukin-11 receptor expression in primary ovarian carcinomas., PMID:11161848
Interleukin-11 signals through the formation of a hexameric receptor complex., PMID:10948192
Monoclonal antibodies against the human interleukin-11 receptor alpha-chain (IL-11Ralpha) and their use in studies of human mononuclear cells., PMID:10915848
Interleukin-11 enhancement of VLA-5 mediated adhesion of CD34+ cells from cord blood to fibronectin is associated with the PI-3 kinase pathway., PMID:10836206
Mutual education between hematopoietic cells and bone marrow stromal cells through direct cell-to-cell contact: factors that determine the growth of bone marrow stroma-dependent leukemic (HB-1) cells., PMID:9680351
Recombinant human interleukin-11 directly promotes megakaryocytopoiesis in vitro., PMID:9354656
Interleukin-6 family of cytokines induced activation of different functional sites expressed by gp130 transducing protein., PMID:8662918
The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures., PMID:8676079
Gp130 in human myeloma/plasmacytoma., PMID:7895494
Interleukin-11., PMID:7532057
Involvement of gp130/interleukin-6 receptor transducing component in interleukin-11 receptor., PMID:8020567
Interleukin-11 and its receptor., PMID:1292471
For research use only. Not for human or drug use.
