Catalog No.
DHD68902
Expression system
Mammalian Cells
Species reactivity
Human
Host species
Human
Isotype
IgG4-kappa
Clonality
Monoclonal
Target
Tumor necrosis factor receptor superfamily member 5, B-cell surface antigen CD40, Bp50, CD40L receptor, TNFRSF5, CDw40, CD40
Concentration
2.18 mg/ml
Endotoxin level
Please contact with the lab for this information.
Purity
>95% as determined by SDS-PAGE.
Purification
Protein A/G purified from cell culture supernatant.
Accession
P25942
Applications
Research Grade Biosimilar
Form
Liquid
Storage buffer
0.01M PBS, pH 7.4.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.
Alternative Names
4D11, ASKP-1240, CAS: 1453067-91-8
Clone ID
Bleselumab
Efficacy and safety of bleselumab in kidney transplant recipients: A phase 2, randomized, open-label, noninferiority study, PMID: 31509331
Randomized, controlled study of bleselumab (ASKP1240) pharmacokinetics and safety in patients with moderate-to-severe plaque psoriasis, PMID: 29679478
A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti-CD40 monoclonal antibody, in kidney transplantation, PMID: 31397943
Costimulation Blockade in Kidney Transplantation: An Update, PMID: 27472094
Current status of costimulatory blockade in renal transplantation, PMID: 27517137
Characterization of ASKP1240, a fully human antibody targeting human CD40 with potent immunosuppressive effects, PMID: 24731050
Long-term hepatic allograft acceptance based on CD40 blockade by ASKP1240 in nonhuman primates, PMID: 22420525
Effects of ASKP1240 combined with tacrolimus or mycophenolate mofetil on renal allograft survival in Cynomolgus monkeys, PMID: 24992357
Pharmacokinetics and pharmacodynamics of ASKP1240, a fully human anti-CD40 antibody, in normal and renal transplanted Cynomolgus monkeys, PMID: 24389907
For research use only. Not for human or drug use.
