Catalog No.
YHK94701
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Asp543-Gly731
Predicted molecular weight
23.78 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
Q9BSW2
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
Calcium release-activated channel regulator 2A, EF-hand calcium-binding domain-containing protein 4B, CRACR2A, RAB46, Ras-related protein Rab-46, EFCAB4B, CRAC channel regulator 2A, Calcium release-activated calcium channel regulator 2A
RNA-seq analysis reveals transcriptome changes in livers from Efcab4b knockout mice., PMID:40034259
Neutrophil CRACR2A Promotes Neutrophil Recruitment in Sterile Inflammation and Ischemic Stroke., PMID:39601147
Transcriptomes of electrophysiologically recorded Dbx1-derived respiratory neurons of the preBötzinger complex in neonatal mice., PMID:35190626
CRACR2A associated immunodeficiency - the supporting factor takes center stage., PMID:35151051
Biallelic mutations in calcium release activated channel regulator 2A (CRACR2A) cause a primary immunodeficiency disorder., PMID:34908525
Gene mapping, gene-set analysis, and genomic prediction of postpartum blood calcium in Holstein cows., PMID:34756434
Large Rab GTPases: Novel Membrane Trafficking Regulators with a Calcium Sensor and Functional Domains., PMID:34299309
Effects of lifestyle interventions on epigenetic signatures of liver fat: Central randomized controlled trial., PMID:33938135
A tunable LIC1-adaptor interaction modulates dynein activity in a cargo-specific manner., PMID:33173051
Rab46 integrates Ca2+ and histamine signaling to regulate selective cargo release from Weibel-Palade bodies., PMID:31092558
CRACR2a is a calcium-activated dynein adaptor protein that regulates endocytic traffic., PMID:30814157
A Combined Targeted and Whole Exome Sequencing Approach Identified Novel Candidate Genes Involved in Heritable Pulmonary Arterial Hypertension., PMID:30679663
Store-operated calcium entry in disease: Beyond STIM/Orai expression levels., PMID:30630032
Vigorous Physical Activity Is Associated with Lower Risk of Metastatic-Lethal Progression in Prostate Cancer and Hypomethylation in the CRACR2A Gene., PMID:30464020
A genome-wide association study identifies an association between variants in EFCAB4B gene and periodontal disease in an Italian isolated population., PMID:30284742
CRACR2A-Mediated TCR Signaling Promotes Local Effector Th1 and Th17 Responses., PMID:29987160
STIM-TRP Pathways and Microdomain Organization: Auxiliary Proteins of the STIM/Orai Complex., PMID:28900915
A large Rab GTPase family in a small GTPase world., PMID:27221160
Molecular modulators of store-operated calcium entry., PMID:27130253
A large Rab GTPase encoded by CRACR2A is a component of subsynaptic vesicles that transmit T cell activation signals., PMID:27016526
Monozygotic twins with NASH cirrhosis: cumulative effect of multiple single nucleotide polymorphisms?, PMID:26845607
Expression of a long variant of CRACR2A that belongs to the Rab GTPase protein family in endothelial cells., PMID:25475730
Genomic influences on alcohol problems in a population-based sample of young adults., PMID:25439982
Key components of store-operated Ca2+ entry in non-excitable cells., PMID:25030742
Molecular regulation of the pore component of CRAC channels, Orai1., PMID:23890116
STIM-ORAI interactions that control the CRAC channel., PMID:23890110
Measurement of intracellular Ca2+ concentration in single cells using ratiometric calcium dyes., PMID:23296601
Cracking CRAC., PMID:20442700
A novel EF-hand protein, CRACR2A, is a cytosolic Ca2+ sensor that stabilizes CRAC channels in T cells., PMID:20418871
For research use only. Not for human or drug use.
