Catalog No.
YHD47201
Expression system
E. coli
Species
Homo sapiens (Human)
Protein length
Arg175-Arg206
Predicted molecular weight
16.19 kDa
Nature
Recombinant
Endotoxin level
Please contact with the lab for this information.
Purity
>90% as determined by SDS-PAGE.
Accession
P21730
Applications
ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Form
Lyophilized
Storage buffer
Lyophilized from a solution in PBS pH 7.4, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Reconstitution
Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.
Shipping
In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.
Stability and Storage
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
Alternative Names
CD88, C5AR1, C5R1, C5AR, C5a-R, C5aR, C5a anaphylatoxin chemotactic receptor 1, C5a anaphylatoxin chemotactic receptor
Association of COVID-19 inflammation with activation of the C5a-C5aR1 axis. PMID: 32726800
CD11c+CD88+CD317+ myeloid cells are critical mediators of persistent CNS autoimmunity. PMID: 33785592
C5a receptor (CD88) blockade protects against MPO-ANCA GN. PMID: 24179165
Overexpression of CD88 predicts poor prognosis in non-small-cell lung cancer. PMID: 23706417
C5aR2 receptor: The genomic twin of the flamboyant C5aR1. PMID: 35977039
Complement receptor C5aR1/CD88 and dipeptidyl peptidase-4/CD26 define distinct hematopoietic lineages of dendritic cells. PMID: 25769922
Blockade of the Complement C5a/C5aR1 Axis Impairs Lung Cancer Bone Metastasis by CXCL16-mediated Effects. PMID: 29327939
Guhong Injection Prevents Ischemic Stroke-Induced Neuro-Inflammation and Neuron Loss Through Regulation of C5ar1. PMID: 35387346
Complement and blood-brain barrier integrity. PMID: 25041699
Avacopan for the treatment of ANCA-associated vasculitis. PMID: 34006155
The Complement Receptor C5aR2: A Powerful Modulator of Innate and Adaptive Immunity. PMID: 31160390
Complement activation fragment C5a receptors, CD88 and C5L2, are associated with neurofibrillary pathology. PMID: 23394121
A Potential Link between the C5a Receptor 1 and the β1-Adrenoreceptor in the Mouse Heart. PMID: 26727203
Schisantherin A attenuates ischemia/reperfusion-induced neuronal injury in rats via regulation of TLR4 and C5aR1 signaling pathways. PMID: 28690033
A New Approach for the Treatment of Arthritis in Mice with a Novel Conjugate of an Anti-C5aR1 Antibody and C5 Small Interfering RNA. PMID: 25917104
Neutraligands of C5a can potentially occlude the interaction of C5a with the complement receptors C5aR1 and C5aR2. PMID: 36565188
Structural sequence evolution and computational modeling approaches of the complement system in leishmaniasis. PMID: 32085887
Vascular Endothelial Cells Produce Coagulation Factors That Control Their Growth via Joint Protease-Activated Receptor and C5a Receptor 1 (CD88) Signaling. PMID: 35144762
Complement C5a Induces Pro-inflammatory Microvesicle Shedding in Severely Injured Patients. PMID: 32983087
Inhibiting the C5-C5a receptor axis. PMID: 21549429
PMX-53 as a dual CD88 antagonist and an agonist for Mas-related gene 2 (MrgX2) in human mast cells. PMID: 21441599
Avacopan for the treatment of ANCA-associated vasculitis: an update. PMID: 36545762
The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases. PMID: 22964232
C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. PMID: 22691190
C5L2: a controversial receptor of complement anaphylatoxin, C5a. PMID: 23239822
C5aR2 Activation Broadly Modulates the Signaling and Function of Primary Human Macrophages. PMID: 32611725
Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans. PMID: 19864971
Cytokine and Complement Response in the Glaucomatous βB1-CTGF Mouse Model. PMID: 34867198
The Role of C5a Receptor Signaling in Endotoxin-Induced Miscarriage and Preterm Birth. PMID: 25846074
Targeted Amino Acid Substitution Overcomes Scale-Up Challenges with the Human C5a-Derived Decapeptide Immunostimulant EP67. PMID: 32233506
Structure of the complement C5a receptor bound to the extra-helical antagonist NDT9513727. PMID: 29300009
Complement C5A regulates prolabor mediators in human placenta. PMID: 22441801
Sexual dimorphism of liver metastasis by murine pancreatic neuroendocrine tumors is affected by expression of complement C5. PMID: 27105526
Cell-surface signatures of immune dysfunction risk-stratify critically ill patients: INFECT study. PMID: 29915941
Surface Modification of Biodegradable Microparticles with the Novel Host-Derived Immunostimulant CPDI-02 Significantly Increases Short-Term and Long-Term Mucosal and Systemic Antibodies against Encapsulated Protein Antigen in Young Naïve Mice after Respiratory Immunization. PMID: 36145590
Derivation of ligands for the complement C3a receptor from the C-terminus of C5a. PMID: 25446428
C5a mediates peripheral blood neutrophil dysfunction in critically ill patients. PMID: 19324972
C5L2 Receptor Represses Brain-Derived Neurotrophic Factor Secretion in Lipoteichoic Acid-Stimulated Pulp Fibroblasts. PMID: 28033061
Activation of basophils is a new and sensitive marker of biocompatibility in hemodialysis. PMID: 24712758
Prostate cancer C5a receptor expression and augmentation of cancer cell proliferation, invasion, and PD-L1 expression by C5a. PMID: 33368414
Cancer cells release anaphylatoxin C5a from C5 by serine protease to enhance invasiveness. PMID: 25050844
Tenocyte activation and regulation of complement factors in response to in vitro cell injury. PMID: 24732065
High expression of C5L2 correlates with high proinflammatory cytokine expression in advanced human atherosclerotic plaques. PMID: 24819959
TLR activation enhances C5a-induced pro-inflammatory responses by negatively modulating the second C5a receptor, C5L2. PMID: 21630250
Human neutrophils switch to an activated phenotype after homing to the lung irrespective of inflammatory disease. PMID: 19077082
Blood clotting and traumatic injury with shock mediates complement-dependent neutrophil priming for extracellular ROS, ROS-dependent organ injury and coagulopathy. PMID: 30260475
C3a and C5a are chemotactic factors for human mesenchymal stem cells, which cause prolonged ERK1/2 phosphorylation. PMID: 19265162
Neutrophil Receptor Response to Bacterial N-formyl Peptides is Similar in Term Newborn Infants and Adults in Contrast to IL-8. PMID: 27606963
Human colonic epithelial cells detect and respond to C5a via apically expressed C5aR through the ERK pathway. PMID: 22496247
The complement component C5a induces the expression of plasminogen activator inhibitor-1 in human macrophages via NF-kappaB activation. PMID: 16879222
Differential expression of the C5a receptor and complement receptors 1 and 3 after LPS stimulation of neutrophils and monocytes. PMID: 15541042
Urokinase-induced activation of the gp130/Tyk2/Stat3 pathway mediates a pro-inflammatory effect in human mesangial cells via expression of the anaphylatoxin C5a receptor. PMID: 15944400
For research use only. Not for human or drug use.
