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Recombinant Human IL11 Protein, N-His-SUMO (YHD42202)

Applications:ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress
Expression system:E. coli
Accession:P20809
Protein length:Asp34-Leu199
Overview

Catalog No.

YHD42202

Expression system

E. coli

Species

Homo sapiens (Human)

Protein length

Asp34-Leu199

Predicted molecular weight

30.34 kDa

Nature

Recombinant

Endotoxin level

Please contact with the lab for this information.

Purity

>90% as determined by SDS-PAGE.

Accession

P20809

Applications

ELISA, Immunogen, SDS-PAGE, WB, Bioactivity testing in progress

Form

Lyophilized

Storage buffer

Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.

Reconstitution

Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details.

Shipping

In general, proteins are provided as lyophilized powder/frozen liquid. They are shipped out with dry ice/blue ice unless customers require otherwise.

Stability and Storage

Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.

Alternative Names

Adipogenesis inhibitory factor, AGIF, IL11, IL-11, Interleukin-11, Oprelvekin

Data Image
  • SDS-PAGE
    SDS PAGE for Recombinant Human IL11 protein
References

Inhaled siRNA nanoparticles targeting IL11 inhibit lung fibrosis and improve pulmonary function post-bleomycin challenge. PMID: 35731866

IL11 Stimulates IL33 Expression and Proinflammatory Fibroblast Activation across Tissues. PMID: 36012165

IL-11 is a crucial determinant of cardiovascular fibrosis. PMID: 29160304

Targeting endogenous kidney regeneration using anti-IL11 therapy in acute and chronic models of kidney disease. PMID: 36470928

Interleukin-11 treatment protected against cerebral ischemia/reperfusion injury. PMID: 31096144

Emerging roles for IL-11 in inflammatory diseases. PMID: 34689057

Osteoblast/osteocyte-derived interleukin-11 regulates osteogenesis and systemic adipogenesis. PMID: 36424386

Hepatectomy promotes recurrence of liver cancer by enhancing IL-11-STAT3 signaling. PMID: 31375423

Interleukin-11. PMID: 7532057

Oxygen-Glucose Deprivation Promoted Fibroblast Senescence and Collagen Expression via IL11. PMID: 36292942

Hepatocyte Specific gp130 Signalling Underlies APAP Induced Liver Injury. PMID: 35806094

IL11: A Specific Repressor of Tumor-Specific CD4+ T Cells. PMID: 34021007

Review: LIF and IL11 in trophoblast-endometrial interactions during the establishment of pregnancy. PMID: 20129664

Emerging roles for Interleukin-11 in disease. PMID: 31161823

Interleukin 11. PMID: 7950912

Fibroblast-specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease. PMID: 32656894

The role of proteolysis in interleukin-11 signaling. PMID: 34624437

IL-11 in multiple sclerosis. PMID: 26452137

Antibody-mediated neutralization of IL11 signalling reduces ERK activation and cardiac fibrosis in a mouse model of severe pressure overload. PMID: 33462828

Interleukin (IL)11 mediates protein secretion and modification in human extravillous trophoblasts. PMID: 21840908

Oprelvekin. Genetics Institute. PMID: 11890354

Interleukin 11 is upregulated in uterine lavage and endometrial cancer cells in women with endometrial carcinoma. PMID: 20553623

Monomeric state of S100P protein: Experimental and molecular dynamics study. PMID: 31103949

The role of IL-11 in immunity and cancer. PMID: 26826523

[The role of interleukin-11 in osteosarcoma]. PMID: 32078699

[Interleukin-11 in Pathologies of the Nervous System]. PMID: 36976735

Therapeutic Targeting of IL-11 for Chronic Lung Disease. PMID: 33612289

[fosB/IL-11]. PMID: 15035097

Targeting IL-11 signaling in colon cancer. PMID: 24163267

Interleukin-11: A Potential Biomarker and Molecular Therapeutic Target in Non-Small Cell Lung Cancer. PMID: 35883698

The pro-regenerative effects of hyperIL6 in drug-induced liver injury are unexpectedly due to competitive inhibition of IL11 signaling. PMID: 34435951

High-affinity interaction between interleukin-11 and S100P protein. PMID: 26551460

Interleukin-11: A Multifunctional Cytokine with Intrinsically Disordered Regions. PMID: 27334537

IL-11 signaling as a therapeutic target for cancer. PMID: 25917632

Interleukin-6 and interleukin-11: same same but different. PMID: 23740659

Toward development of interleukin-11 as a medical countermeasure for use in radiological/nuclear emergencies. PMID: 24591015

IL-11 drives postsurgical hepatocellular carcinoma recurrence. PMID: 31402232

Interleukin-11 and its receptor. PMID: 1292471

The cytokine interleukin-11 crucially links bone formation, remodeling and resorption. PMID: 33940443

Split2 Protein-Ligation Generates Active IL-6-Type Hyper-Cytokines from Inactive Precursors. PMID: 29136368

Generation of and characterization of anti-IL-11 antibodies using newly established Il11-deficient mice. PMID: 30268501

A panoramic review and in silico analysis of IL-11 structure and function. PMID: 27312790

Different roles of interleukin 6 and interleukin 11 in the liver: implications for therapy. PMID: 32530750

Interleukin-11. A gp130 cytokine. PMID: 9917860

Interleukin 11: an overview. PMID: 8111307

The biology of interleukin 11. PMID: 8401258

Interleukin 11 is upregulated in preeclampsia and leads to inflammation and preeclampsia features in mice. PMID: 29195119

Roles of interleukin-11 during acute bacterial pneumonia. PMID: 31415618

Inactivation of IL11 signaling causes craniosynostosis, delayed tooth eruption, and supernumerary teeth. PMID: 21741611

Interleukin-11 up-regulates endoplasmic reticulum stress induced target, PDIA4 in human first trimester placenta and in vivo in mice. PMID: 28487027

Re-thinking the role of IL-11 in liver injury. PMID: 34183810

Leukemia inhibitory factor and interleukin-11: critical regulators in the establishment of pregnancy. PMID: 19647472

Interleukin-11: a novel stroma-derived cytokine. PMID: 1307488

Cytokine signalling via gp130 in gastric cancer. PMID: 19665497

Interleukin-11 alters placentation and causes preeclampsia features in mice. PMID: 26655736

Human cytomegalovirus replication induces endothelial cell interleukin-11. PMID: 29807687

Generation of Soluble Interleukin-11 and Interleukin-6 Receptors: A Crucial Function for Proteases during Inflammation. PMID: 27493449

Regulation of interleukin-11 expression in ovulatory follicles of the rat ovary. PMID: 28521851

Critical Conditions for Studying Interleukin-11 Signaling In Vitro and Avoiding Experimental Artefacts. PMID: 34570432

Cytokine therapy in rheumatoid arthritis. PMID: 9836382

Interleukin 11 regulates endometrial cancer cell adhesion and migration via STAT3. PMID: 22614117

The expression analysis of Fra-1 gene and IL-11 protein in Iranian patients with ulcerative colitis. PMID: 29914371

[Interleukin-11, an IL-6 like cytokine]. PMID: 21485496

Interleukin-11: its biology and prospects for clinical use. PMID: 10483899

Regulation of osteoblast differentiation by interleukin-11 via AP-1 and Smad signaling. PMID: 21931225

Structural Understanding of Interleukin 6 Family Cytokine Signaling and Targeted Therapies: Focus on Interleukin 11. PMID: 32765502

Preeclampsia-related increase of interleukin-11 expression in human decidual cells. PMID: 20668109

Understanding the link between the IL-6 cytokine family and pregnancy: implications for future therapeutics. PMID: 21895473

More than a sidekick: the IL-6 family cytokine IL-11 links inflammation to cancer. PMID: 20610798

Emerging roles for IL-11 signaling in cancer development and progression: Focus on breast cancer. PMID: 26209885

Expression, Purification, and Characterization of Interleukin-11 Orthologues. PMID: 27916836

Management of chemotherapy-induced thrombocytopenia: current status of thrombopoietic agents. PMID: 19245931

Hematopoietic, immunomodulatory and epithelial effects of interleukin-11. PMID: 10482979

Interleukin-11: review of molecular, cell biology, and clinical use. PMID: 9166826

Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment. PMID: 7512836

The role of IL-II in hematopoiesis as revealed by a targeted mutation of its receptor. PMID: 11012177

Interactions between glucocorticoids and cytokines in the bone microenvironment. PMID: 12114264

IL-11: insights in asthma from overexpression transgenic modeling. PMID: 11590369

Mutational Analysis of Interleukin-11 and its Consequences on Cancer and COVID-19 Related Cytokine Storm -An Extensive Molecular Dynamics Study. PMID: 35382714

[Function, molecular structure and gene expression of interleukin-11 (IL-11/AGIF)]. PMID: 1433976

Biologic and structural differences of thrombopoietic growth factors. PMID: 10831285

Use of thrombopoietic growth factors in acute leukemia. PMID: 10720151

Interleukin-11 is important for vascular smooth muscle phenotypic switching and aortic inflammation, fibrosis and remodeling in mouse models. PMID: 33082445

MEK/ERK/RUNX2 Pathway-Mediated IL-11 Autocrine Promotes the Activation of Müller Glial Cells during Diabetic Retinopathy. PMID: 36154781

CD39+ Fibroblasts Enhance Myofibroblast Activation by Promoting IL-11 Secretion in Hypertrophic Scars. PMID: 34537192

Effect of interleukin 11 on normal and pathological thrombopoiesis. PMID: 8765427

Review of a novel hematopoietic cytokine, interleukin-11. PMID: 8454414

The cloning and biological characterization of recombinant human interleukin 11. PMID: 1535352

Thrombopoietic activity of recombinant human interleukin 11 in cancer patients receiving chemotherapy. PMID: 8765426

Interleukin 11 treatment alters the protein content of Galpha(i2) and adipogenic transcription factors in 3T3-L1 adipocytes. PMID: 15207245

The interleukin-11/receptor complex: rational design of agonists/antagonists and immunoassays potentially useful in human therapy. PMID: 9851534

Decreased interleukin-11 levels in the semen of infertile males. PMID: 29573586

Estrogen receptor variant ERα46 and insulin receptor drive in primary breast cancer cells growth effects and interleukin 11 induction prompting the motility of cancer-associated fibroblasts. PMID: 34841688

A polymorphic dinucleotide repeat in the 5' flanking region of the human interleukin 11 (IL11) gene. PMID: 9553159

miR-10396b-3p inhibits mechanical stress-induced ligamentum flavum hypertrophy by targeting IL-11. PMID: 34042220

Complex pattern of interleukin-11-induced inflammation revealed by mathematically modeling the dynamics of C-reactive protein. PMID: 25231819

The clinical development of recombinant human interleukin 11 (NEUMEGA rhIL-11 growth factor). PMID: 11012229

Preclinical biology of interleukin 11: a multifunctional hematopoietic cytokine with potent thrombopoietic activity. PMID: 8528095

[International therapeutics]. PMID: 14974887

IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis. PMID: 36376885

Interleukin (IL)-11--mediated signal transduction. PMID: 7545369

Preclinical pharmacologic basis for clinical use of rhIL-11 as an effective platelet-support agent. PMID: 11033834

[Interleukin-11, 12, 13, 14, 15, 16, 17, 18 (IL-11, 12, 13, 14, 15, 16, 17, 18)]. PMID: 16149457

Interleukin-11 classic but not trans-signaling is essential for fertility in mice. PMID: 28864002

Datasheet
$ 313
Product specifications
100 μg 313 1 mg 1629

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Recombinant Human IL11 Protein, N-His-SUMO [YHD42202]
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