Exosomal CD73 from serum of patients with melanoma suppresses lymphocyte functions and is associated with therapy resistance to anti-PD-1 agents. PMID: 35273100
Avoiding phagocytosis-related artifact in myeloid derived suppressor cell T-lymphocyte suppression assays. PMID: 27856191
A simple and effective method to purify and activate T cells for successful generation of chimeric antigen receptor T (CAR-T) cells from patients with high monocyte count. PMID: 36536403
Soluble and Immobilized Anti-CD3/28 Distinctively Expand and Differentiate Primary Human T Cells: An Implication for Adoptive T Cell Therapy. PMID: 36640054
Genetic polymorphism rs8193036 of IL17A is associated with increased susceptibility to pulmonary tuberculosis in Chinese Han population. PMID: 31864094
Chrysophanol Mitigates T Cell Activation by Regulating the Expression of CD40 Ligand in Activated T Cells. PMID: 32854357
Conditional IL-2 Gene Deletion: Consequences for T Cell Proliferation. PMID: 22590468
Kruppel-like factor 2 modulates CCR5 expression and susceptibility to HIV-1 infection. PMID: 22988032
Third-party umbilical cord blood-derived regulatory T cells prevent xenogenic graft-versus-host disease. PMID: 24480547
Differential activation of intraepithelial lymphocyte-natural killer cells in chickens infected with very virulent and vaccine strains of infectious bursal disease virus. PMID: 29886054
T-cell receptor/CD28-mediated activation of human T lymphocytes induces expression of functional mu-opioid receptors. PMID: 18463202
TNFR2 Expression on CD25(hi)FOXP3(+) T Cells Induced upon TCR Stimulation of CD4 T Cells Identifies Maximal Cytokine-Producing Effectors. PMID: 23964278
Blockade of CD11a by efalizumab in psoriasis patients induces a unique state of T-cell hyporesponsiveness. PMID: 18239614
Activation of human T cells induces upregulation of cannabinoid receptor type 1 transcription. PMID: 18287809
Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells. PMID: 28550199
Optimization of cGMP purification and expansion of umbilical cord blood-derived T-regulatory cells in support of first-in-human clinical trials. PMID: 27887864
[In vitro expansion of T cells stimulated by combination of IL-2, IL-7 and IL-15]. PMID: 21176376
Directly infected resting CD4+T cells can produce HIV Gag without spreading infection in a model of HIV latency. PMID: 22911005
Human CD8+ T cells do not require the polarization of lipid rafts for activation and proliferation. PMID: 12419850
Restoration of corticosteroid sensitivity by p38 mitogen activated protein kinase inhibition in peripheral blood mononuclear cells from severe asthma. PMID: 22911818
Ex Vivo Bioactivity and HIV-1 Latency Reversal by Ingenol Dibenzoate and Panobinostat in Resting CD4(+) T Cells from Aviremic Patients. PMID: 26169416
Quantitative assessment of human T lymphocytes in RAG2(-/-)gammac(-/-) mice: the impact of ex vivo manipulation on in vivo functionality. PMID: 17198880
Anti-GD2 synergizes with CD47 blockade to mediate tumor eradication. PMID: 35027753
The Roles of Siglec7 and Siglec9 on Natural Killer Cells in Virus Infection and Tumour Progression. PMID: 32322597
Identification of a cytokine-dominated immunosuppressive class in squamous cell lung carcinoma with implications for immunotherapy resistance. PMID: 35799269
Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9. PMID: 33627655
Genome-wide CRISPR screens reveal a specific ligand for the glycan-binding immune checkpoint receptor Siglec-7. PMID: 33495350
The ceramide moiety of disialoganglioside (GD3) is essential for GD3 recognition by the sialic acid-binding lectin SIGLEC7 on the cell surface. PMID: 31138648
Siglecs-7/9 function as inhibitory immune checkpoints in vivo and can be targeted to enhance therapeutic antitumor immunity. PMID: 34155121
Inhibitory Receptors and Checkpoints in Human NK Cells, Implications for the Immunotherapy of Cancer. PMID: 33013909
SIGLEC1 and SIGLEC7 expression in circulating monocytes of patients with multiple sclerosis. PMID: 22933622
Targeting hypersialylation in multiple myeloma represents a novel approach to enhance NK cell-mediated tumor responses. PMID: 35294519
Binding specificity of siglec7 to disialogangliosides of renal cell carcinoma: possible role of disialogangliosides in tumor progression. PMID: 11389909
Gangliosides as Siglec ligands. PMID: 36701102
Human Immunity Against Campylobacter Infection. PMID: 31921468
Siglec-7, a target for novel therapeutical approaches of Systemic Mastocytosis. PMID: 32126271
Immunotherapy approaches on innate immunity for SARS-Cov-2. PMID: 32985199
Immunosuppressive glycoproteins associate with breast tumor fibrosis and aggression. PMID: 35392183
Genetically encoded chemical crosslinking of carbohydrate. PMID: 36216893
Viewing Siglecs through the lens of tumor immunology. PMID: 28258691
Chemical Synthesis and Evaluation of a Disialic Acid-Containing Dextran Polymer as an Inhibitor for the Interaction between Siglec 7 and Its Ligand. PMID: 28374980
Multi-omics analysis of Siglec family genes in cutaneous melanoma. PMID: 37207210
Cryopreservation alters the immune characteristics of platelets. PMID: 34636427
The immunobiology of Campylobacter jejuni: Innate immunity and autoimmune diseases. PMID: 26709064
Features of Memory-Like and PD-1(+) Human NK Cell Subsets. PMID: 27683578
Gangliosides in cell recognition and membrane protein regulation. PMID: 19608407
Siglec-7 mediates varicella-zoster virus infection by associating with glycoprotein B. PMID: 35367830
Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection. PMID: 33200082
Chemoenzymatic Synthesis of DSGb5 and Sialylated Globo-series Glycans. PMID: 31140679
Regulation of Siglec-7-mediated varicella-zoster virus infection of primary monocytes by cis-ligands. PMID: 35526487
International Prognostic Index-Based Immune Prognostic Model for Diffuse Large B-Cell Lymphoma. PMID: 34745101
Impaired intratumoral natural killer cell function in head and neck carcinoma. PMID: 36341402
Altered mechanisms of genital development identified through integration of DNA methylation and genomic measures in hypospadias. PMID: 32728162
Host Immune Responses in HIV-1 Infection: The Emerging Pathogenic Role of Siglecs and Their Clinical Correlates. PMID: 28386256
Sugar Free: Novel Immunotherapeutic Approaches Targeting Siglecs and Sialic Acids to Enhance Natural Killer Cell Cytotoxicity Against Cancer. PMID: 31143186
Human natural killer cell receptors: insights into their molecular function and structure. PMID: 14754506
ST8Sia6 Promotes Tumor Growth in Mice by Inhibiting Immune Responses. PMID: 34074677
Modulation of Siglec-7 Signaling Via In Situ-Created High-Affinity cis-Ligands. PMID: 34471678
Analyzing glycan-binding patterns with the ProfilePSTMM Tool. PMID: 25753712
Siglec-7 on peripheral blood eosinophils: Surface expression and function. PMID: 30690753
Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells. PMID: 33640457
Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis. PMID: 34659241
MYC-driven synthesis of Siglec ligands is a glycoimmune checkpoint. PMID: 36897988
Carbohydrate antigen sialyl Lewis a--its pathophysiological significance and induction mechanism in cancer progression. PMID: 17760270
Pathologic natural killer cell subset redistribution in HIV-1 infection: new insights in pathophysiology and clinical outcomes. PMID: 20651298
Natural killer cell phenotype is altered in HIV-exposed seronegative women. PMID: 32870938
Installation of high-affinity Siglec-1 ligand on tumor surface for macrophage-engaged tumor suppression. PMID: 34425200
Discovery of a new sialic acid binding region that regulates Siglec-7. PMID: 32457377
Experimental determination and data-driven prediction of homotypic transmembrane domain interfaces. PMID: 33209210
The conserved arginine residue in all siglecs is essential for Siglec-7 binding to sialic acid. PMID: 33248687
Siglec Receptors Modulate Dendritic Cell Activation and Antigen Presentation to T Cells in Cancer. PMID: 35309936
Alzheimer's disease-associated inflammatory pathways might contribute to osteoporosis through the interaction between PROK2 and CSF3. PMID: 36203970
Combining CuAAC reaction enables sialylated Bi- and triantennary pseudo mannose N-glycans for investigating Siglec-7 interactions. PMID: 35640379
Targeting glycosylated antigens on cancer cells using siglec-7/9-based CAR T-cells. PMID: 32391973
Chemoenzymatic synthesis of the oligosaccharide moiety of the tumor-associated antigen disialosyl globopentaosylceramide. PMID: 31339142
Comprehensive analysis of angiogenesis subtype of squamous cell carcinoma. PMID: 34521431
Molecular Basis and Role of Siglec-7 Ligand Expression on Chronic Lymphocytic Leukemia B Cells. PMID: 35711441
Siglec-7 represents a glyco-immune checkpoint for non-exhausted effector memory CD8+ T cells with high functional and metabolic capacities. PMID: 36211376
Macrophages as a source of fibrosis biomarkers for non-alcoholic fatty liver disease. PMID: 33444517
Adaptive Reconfiguration of Natural Killer Cells in HIV-1 Infection. PMID: 29616021
Synthesis and biological evaluation of 9-N-oxamyl sialosides as Siglec-7 ligands. PMID: 26234906
Decidual glycodelin-A polarizes human monocytes into a decidual macrophage-like phenotype through Siglec-7. PMID: 32513821
BGN/TLR4/NF-B Mediates Epigenetic Silencing of Immunosuppressive Siglec Ligands in Colon Cancer Cells. PMID: 32050430
Siglec-7 is an indicator of natural killer cell function in acute myeloid leukemia. PMID: 34273636
Siglec-7 May Limit Natural Killer Cell-mediated Antitumor responses in Bladder Cancer Patients. PMID: 34825225
Sialylated IgG in epithelial cancers inhibits antitumor function of T cells via Siglec-7. PMID: 36310398
The mucin-selective protease StcE enables molecular and functional analysis of human cancer-associated mucins. PMID: 30910957
Ganglioside binding pattern of CD33-related siglecs. PMID: 12639556
[Functions of sialic acids-binding lectins, Siglecs]. PMID: 12807015
DNA methylation-mediated Siglec-7 regulation in natural killer cells via two 5' promoter CpG sites. PMID: 32027025
Reduced Siglec-7 expression on NK cells predicts NK cell dysfunction in primary hepatocellular carcinoma. PMID: 32319079
Siglec-7 is a predictive biomarker for the efficacy of cancer vaccination against metastatic colorectal cancer. PMID: 33240416
Role of Siglec-7 in apoptosis in human platelets. PMID: 25230315
Targeting stromal cell sialylation reverses T cell-mediated immunosuppression in the tumor microenvironment. PMID: 37167967
Abnormal expression and clinical significance of surface receptors on natural killer cells in the peripheral blood of patients with non-small cell lung cancer. PMID: 35652620
Increased expression of TIGIT and KLRG1 correlates with impaired CD56bright NK cell immunity in HPV16-related cervical intraepithelial neoplasia. PMID: 35413989
Siglec-7 is an inhibitory receptor on human mast cells and basophils. PMID: 24810846
Siglec-7 Defines a Highly Functional Natural Killer Cell Subset and Inhibits Cell-Mediated Activities. PMID: 27312286
Expression profiling of immune inhibitory Siglecs and their ligands in patients with glioma. PMID: 30953118
Chemical synthesis of a synthetic analogue of the sialic acid-binding lectin siglec-7. PMID: 25277834
Siglec-7 tetramers characterize B-cell subpopulations and leukemic blasts. PMID: 22585296
Sugar nucleotide regeneration system for the synthesis of Bi- and triantennary N-glycans and exploring their activities against siglecs. PMID: 35149460
B7-H6-mediated downregulation of NKp30 in natural killer cells contributes to HIV-2 immune escape. PMID: 30325780
Increased Frequency of Dysfunctional Siglec-7-CD57+PD-1+ Natural Killer Cells in Patients With Non-alcoholic Fatty Liver Disease. PMID: 33692781
A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C. PMID: 34228858
Targeting Siglecs with a sialic acid-decorated nanoparticle abrogates inflammation. PMID: 26333936
Metabolic sialic acid blockade lowers the activation threshold of moDCs for TLR stimulation. PMID: 27874015
Siglec-7 restores β-cell function and survival and reduces inflammation in pancreatic islets from patients with diabetes. PMID: 28378743
Exposure of Keratinocytes to Candida Albicans in the Context of Atopic Milieu Induces Changes in the Surface Glycosylation Pattern of Small Extracellular Vesicles to Enhance Their Propensity to Interact With Inhibitory Siglec Receptors. PMID: 35784319
For research use only. Not for human or drug use.
